Comments on: A History of Cell Wall Deficient Bacteria: A Selection of Researchers Who Have Worked with the L-form

By: Amy Proal

Amy Proal — Thu, 11 Dec 2008 16:06:40 +0000

Hi Syed,

Glad to be of help and glad you are writing about L-forms!

Best,

Amy

By: syed hafiz

syed hafiz — Thu, 11 Dec 2008 16:04:00 +0000

This is very useful for my final exam.Thank you

By: Vics

Vics — Tue, 06 May 2008 06:43:57 +0000

If this leads to a blood test for me/cfs then I’m all for it! So nice to read something medical that a lay person can understand for a change! kudos on the site, it’s a marvel.

By: valenciamosley

valenciamosley — Thu, 28 Feb 2008 19:37:28 +0000

this is very nice

By: Amy Proal

Amy Proal — Sat, 16 Feb 2008 18:56:34 +0000

Hi D Bergy,

I’m glad you find this site to be informative and thanks for your nice comments about my work!

The MP is the only treatment that effectively kills L-form bacteria, so the only way people with MS could target Borrelia L-forms would be through the MP. However since the MP kills different species of L-form bacteria simultaneously, it would be impossible to do a study in which only Borrelia L-forms were being killed.

Unfortunately high dose and IV antibiotics do not effectively kill L-form bacteria, because as described in this article, at such high doses, they negatively affect the immune system:

“Getting it Right: How to correctly target L-form bacteria”

http://bacteriality.com/2007/10/11/antibiotics/

The good news is that there are an increasing number of MS patients on the MP who appear to be recovering in the same fashion as people with other Th1 diseases. They are definitely experiencing immunopathology - a clear indication that L-form bacteria are being targeted.

Best,

Amy

By: D Bergy

D Bergy — Sat, 16 Feb 2008 04:33:13 +0000

“She cultured serum from forty patients with multiple sclerosis and found a different species of the borrelia L-form present in her samples.”

I guess my question is: Has anyone tried to treat this strain of borrelia in an actual MS patient to see if it has any effect on their condition?

This is the best bacterial site I have seen on the net. I applaud your effert and really appreciate the work you have done.

By: Gerald J. Domingue

Gerald J. Domingue — Wed, 12 Sep 2007 00:33:18 +0000

The article written by Ms. Amy Proal on cell wall-deficient bacteria was brought to my attention by a colleague. I retired from active research/academia ten years ago; however,I continue to have an interest
in the literature on bacterial persistence and expression of disease. A large part of my scientific career (30 years) was devoted to a study of the basic biology of cell wall-defective bacteria,cell wall-deficient bacteria, L-forms, Large Bodies, Cryptic bacteria (or whatever you wish to name them) and their possible role in disease. Since retirement, I have refrained from commenting on any type of publication in the field; however, I thought it might be worthwhile and helpful to Ms. Proal and to those who do not know the literature or deliberately choose to ignore it, to call attention to the following peer reviewed publications. It is disappointing to see nowadays that many researchers/writers fail to appropriately cite relevant references from the past scientific and medical literature. This all falls in what I call the “ethics of scientific writing” which too often is violated. Sometimes ridiculously tumid claims are made in papers; many unsubstantiated by scientific data or evidence.

Following are selected relevant references from the peer reviewed scientific literature (as well as a book) on atypical or cryptic bacterial studies emanating from my laboratory over several decades which may be useful to consider:

l. Journal of Urology. 104:790-798, 1970.
2. Investigative Urology. 9:282:285, 1972.
3. Proceed. of Soc. for Exptl. Biol. and Med. 146:635-642, 1974.
4. Infection and Immunity. 10:889-914, 1974.
5. Infection and Immunity. 10:915-917, 1974.
6. Microbia. 1:3, 1976.
7. Infection and Immunity. 15:621-627, 1977.
8. Journal of Urology. 120:708-711, 1978.
9. Trans. Am. Assoc. Genito-Urinary Surg. 69:61-64, 1978,
10. Archives of Internal Medicine. 139:1355-1360, 1979.
11. Urol. Survey. 30:1-4, 1980.
12. J. Urol. 150:483-485, 1993.
13. J. Urology. 153:1321-1326, 1995.
14. Endocytobiosis and Cell Research, 11:19-40, 1995.

Book:
Domingue, G.J., Editor, Cell Wall-Deficient Bacteria: Basic Principles and Clinical Significance, Addison-Wesley Publishing Co., Reading, MA, 1982.

Gerald J. Domingue
Zurich, Switzerland

Professor Emeritus
Tulane University School of Medicine and Graduate School
New Orleans, Louisiana