This is fascinating!

By the first explanation you site, the study’s conclusion, that the human DNA in the blood is different from the human DNA in the heart tissue, is wrong. By the remaining explanations you site, the study conclusion is correct but we now have a possible explanation for the study’s conclusion.

How can the bacteria interfere with DNA repair? Is it by downregulating the innate immune system through the VDR or is it by some other more direct means or both? I believe I read somewhere that one of the activities of the innate immune system is to provide the means for DNA repair.

Ken

Thanks for the info. I spoke with Dr. Marshall about the study yesterday. He said some explanation for the data are as follows:

1. We don’t know what’s going on

2. Measurement errors – when the scientist sequence the cellular DNA it gets cut up into small bits of nucleotides that patched back together by the computer. However, we now know that bacterial DNA is very similar to human DNA. If the cells harbor bacteria, then bacterial DNA could be getting caught up in the human DNA samples and would be fractured along with the human DNA. Then when the computer tries to put the genetic sequences together it doesn’t account for the presence of the bacterial DNA and cells can end up with different sequences.

3. Bacteria in the cell are interfering with DNA repair. This would cause the DNA in various cells to change with time. But we don’t know all that much about cellular DNA mechanisms to date.

4. Bacteria could be causing direct mutations to the human cellular DNA. While possible, we don’t yet have a model for how exactly how mutation occurs.

5. Integration of bacterial DNA with human DNA – what you proposed. eg horizontal gene transfer. While this may have some effect, Dr. Marshall thinks it probably accounts least for what the researchers observed.

Of course the results could be due to any combination of the above as well.

This is still speculation but a bit more specific.

Best,

Amy

McGill University describes the study on this site:

http://www.mcgill.ca/newsroom/news/item/?item_id=107673.

Ken

I looked up the paper you seem to be referring to, which I believe is this one:
http://www.ncbi.nlm.nih.gov/pubmed/19514060

There are a lot of variables that could account for what was observed in the study. I would rather not speculate. So, at this point, I don’t have a definitive answer.

Paul

I’m very, very sorry to hear about your Dad. In my opinion, there’s a strong possibility that your Dad’s wounds and ulcers could actually be infected by large quantities of bacteria in a biofilm state – a state in which they join together and form communities that can look like pus.

There is an interview on this site with Dr. Randall Wolcott. He is a wound specialist who treats the bacteria in such diabetic wounds. He used to have to amputate most of his patient’s limbs before he discovered the bacteria in their wounds. Now that he has discovered that the wounds are covered in bacteria he can generally kill the bacteria, control the wound, and save the limb.

He would definitely be the person to talk to about your Dad’s situation. While he practices in Texas, he may know someone in Michigan whom he could refer you to or he may simply be able to guide your Dad’s doctors over the phone.

Here is the interview with Dr. Wolcott:

http://bacteriality.com/2008/04/13/wolcott/

Here is his phone number:

806-793-8869

His website is:

woundcarecenter.net

I really hope he can help you.

Best,

Amy

No, I haven’t looked at MMS. When I google MMS I don’t come up with anything that seems like a biofilm-targeting compound.

I’m assuming MMS would be a compound that could be used on external biofilms only? In that case, you may want to direct your questions to the Center for Biofilm Engineering at Montana state University. Their research teams know a lot more than I do about specific compounds and biofilms.

Here’s the link to their website:

http://www.erc.montana.edu/

Best,

Amy

surely you have heard about it?

did not know how to contact you

let me know

jj