Comments on: Study shows the Vitamin D Receptor maintains the integrity of the intestines http://bacteriality.com/2008/05/21/komice/ Tue, 06 Jan 2009 04:42:18 +0000 http://wordpress.org/?v=2.7 hourly 1 By: Amy Proal http://bacteriality.com/2008/05/21/komice/comment-page-1/#comment-7990 Amy Proal Mon, 23 Jun 2008 20:35:02 +0000 http://bacteriality.com/?p=198#comment-7990 Hi Jeannine, Yes, I think that hypothesis is plausible considering the data in this study. It's quite likely many of the thousands of genes transcribed by the VDR are extremely important in activating pathways that might allow for better resistance to toxins on behalf of the tissues. It's important to keep in mind that blocking the VDR will not just affect innate immunity but also the genetic pathways usually controlled by the active receptor. Of course, this study only focused on the effect of a deactivated VDR in the gut, but based on the MP Pathogenesis and other studies on VDR knockout mice, we know that a deactivated VDR anywhere in the body is cause for concern. It does seem that people with Th1 diseases start to become more sensitive to elements of their surroundings. Sometimes they can't handle certain smells, foods, chemicals (in creams or perfumes) etc. Right now such reactions are largely attributed to "allergies" which I'm not sure gives an accurate description of what's going on. Maybe they also become more affected by pollutants which could contribute to their symptoms. I'm not sure if all areas of the body are more prone to possible toxic damage due to VDR blockage or if each individual organ reacts differently. That is something more future studies will hopefully clarify! Best, Amy Hi Jeannine,

Yes, I think that hypothesis is plausible considering the data in this study. It’s quite likely many of the thousands of genes transcribed by the VDR are extremely important in activating pathways that might allow for better resistance to toxins on behalf of the tissues. It’s important to keep in mind that blocking the VDR will not just affect innate immunity but also the genetic pathways usually controlled by the active receptor.

Of course, this study only focused on the effect of a deactivated VDR in the gut, but based on the MP Pathogenesis and other studies on VDR knockout mice, we know that a deactivated VDR anywhere in the body is cause for concern.

It does seem that people with Th1 diseases start to become more sensitive to elements of their surroundings. Sometimes they can’t handle certain smells, foods, chemicals (in creams or perfumes) etc. Right now such reactions are largely attributed to “allergies” which I’m not sure gives an accurate description of what’s going on. Maybe they also become more affected by pollutants which could contribute to their symptoms.

I’m not sure if all areas of the body are more prone to possible toxic damage due to VDR blockage or if each individual organ reacts differently. That is something more future studies will hopefully clarify!

Best,

Amy

]]> By: Jeannine http://bacteriality.com/2008/05/21/komice/comment-page-1/#comment-7986 Jeannine Mon, 23 Jun 2008 15:31:34 +0000 http://bacteriality.com/?p=198#comment-7986 So I guess we can make a hypothesis...and look at this research and predict that toxic substances can be more of a threat/ harmful to those who have an imparied immune system versus one that is fully functioning...I guess this would also include which organ is infected? or do we look at the immune system on a systemic scale? Jeannine So I guess we can make a hypothesis…and look at this research and predict that toxic substances can be more of a threat/ harmful to those who have an imparied immune system versus one that is fully functioning…I guess this would also include which organ is infected? or do we look at the immune system on a systemic scale?

Jeannine

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