Bacteriality — Exploring Chronic Disease

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About the Marshall Protocol

The Marshall Protocol is a medical treatment being used by physicians worldwide to treat a variety of chronic inflammatory and autoimmune diseases including (but not limited to) sarcoidosis, Chronic Fatigue Syndrome, fibromyalgia, Crohn’s Disease, and rheumatoid arthritis. While other treatments for chronic disease use palliative medications in an effort to cover up symptoms, the Marshall Protocol is a curative treatment, which strives to address the root cause of the disease process.

Information about the treatment can be found at the study site, marshallprotocol.com and also at autoimmunityresearch.org. The site is run by the staff of the Autoimmunity Research Foundation, a California-based non-profit agency. Over 200 health professionals are members of the site, and discussions are moderated by volunteer moderators. There is no charge to use the website or the treatment and all patients are welcome to participate.

The FDA has already granted orphan product designations for two of Autoimmunity Research Foundation’s six applications – Sarcoidosis, and Post Treatment Lyme Disease Syndrome (PTLDS, commonly known as chronic Lyme). The Foundation continues to work with the FDA to make effective therapies available in an even wider array of chronic diagnoses.

Chronic Disease

The Marshall Protocol is based on the hypothesis that chronic diseases (termed Th1 illnesses), are the result of infection by an intraphagocytic, metagenomic microbiota of chronic bacterial forms that are often referred to as the Th1 pathogens. The term intraphagocytic refers to the fact that these bacteria have developed the ability to remain alive and proliferate undetected inside the cytoplasm of the cells they infect. These cells include macrophages, the very cells of the immune system that the body uses to kill invading pathogens. Once inside these cells, they cause our own cells to release inflammatory cytokines (proteins that often generate pain and/or fatigue).

The term metagenomic indicates that there is a tremendous number of different species of these chronic bacterial forms. Finally, the term microbiota refers to the fact that these bacteria are also hypothesized to sustain themselves by grouping into communities called biofilms. The bacteria inside a biofilm produce a protective matrix that allows them to more effectively evade the immune system and develop resistance to antibiotics.

Many of the Th1 pathogens are also postulated to be in a chronic state referred to as the L-form. L-form bacteria simply represent part of the natural life cycles of classical bacteria. Under certain conditions, they mutate from classical bacteria, losing their cell walls in the process. Although researchers have known about L-form bacteria for over a century, up until recently they have not fully understood their role in causing chronic disease. Because they lack a cell wall, many antibiotics are unable to kill them directly and they cannot be detected by standard laboratory tests.

The ability of the Th1 pathogens to proliferate in the body is directly related to the vitamin D receptor (VDR). Critically important to the body, the Vitamin D Receptor (VDR) controls the innate immune system – the body’s first line of defense against infection. It’s also responsible for turning on/off a wide array of genes and chemical pathways. One of the VDR’s myriad jobs is to control expression of several families of antimicrobial peptides (AMPs), proteins that kill bacteria, viruses and fungi by a variety of mechanisms including disrupting membranes, interfering with metabolism, and targeting components of the machinery inside the cell.

Although casually referred to as a vitamin by some members of the medical community, molecular biologists have long realized that the precursor form of vitamin D (25-D) is really a secosteroid. Recent molecular modeling research (which has been confirmed by a large amount of clinical data) has shown that levels of 25-D over 20 ng/ml can bind and inactivate the VDR, which subsequently shuts down the innate immune system.

Certain species of bacteria also produce substances that can bind and inactivate the VDR in a manner similar to 25-D. Consequently, people who are infected with the Th1 pathogens and consuming vitamin D are no longer able to produce the AMPs or turn on the innate immune response. This allows their bacteria to proliferate and spread.

When the innate immune system can no longer function, people have a very hard time keeping other pathogens under control. They often find that childhood viral infections reactivate, or that they acquire Candida (pathogenic yeast) and Mycoplasma as well. Thus, every person who starts the MP has a different mix of pathogens to kill depending on what microbes they have encountered during various stages of life. A person’s unique mix of pathogens is often referred to as their “toxigenic pea soup.”

Research indicates that the Th1 pathogens have evolved mechanisms that allow them to both mutate and alter the expression of the genes inside the cells they infect. These effects on the genes result in changes in the cellular environment that make it easier for new pathogens to invade the cell – creating a snowball effect where, as a person acquires more pathogens, it becomes even easier for them to pick up a diverse array of other infectious agents. This process is known as successive infection.

Since the Th1 pathogens have been shown to survive in the sperm and egg, and evidence is growing that they can also pass through the placental barrier, they can be passed from parent to child – meaning that Th1 illnesses often run in families. In addition, the bacterial forms may be easily passed by human contact to an infant soon after birth, during the period before the adaptive immune system is up and running.

Unlike its inactive counterpart, 25-D, that inactivates the VDR in healthy individuals, 1,25-D binds and activates the VDR. But in individuals who have 25-D and bacterial proteins blocking the VDR, 1,25-D is forced out of the receptor and into the surrounding environment.

Furthermore, in healthy individuals, the VDR transcribes an enzyme called CYP24. CYP24 breaks down excess 1,25-D, ensuring that the level of 1,25-D in the body stays in the normal range. But in chronically ill individuals, the VDR (which is blocked by bacterial susbstances) can no longer transcribe CYP24. The level of 1,25-D in the body becomes significantly elevated since there is no CYP24 to keep it in check.

Another enzyme called CYP27B1 normally regulates the amount of 25-D converted into 1,25-D. When more CYP27B1 is produced, conversion occurs at a greater rate. The cytokines released by the immune system in response to the Th1 pathogens activate a protein called Protein Kinase A (PKA). PKA in turn activates CYP27B1, causing more 25-D to be converted to 1,25-D.

These processes cause 1,25-D to rise to an unnaturally high level. Unfortunately, when 1,25-D reaches a certain threshold, it binds not just the VDR, but many of the body’s other nuclear receptors, displacing the metabolites that are meant to be in the receptors under normal conditions.

The nuclear receptors affected by 1,25-D are receptors that regulate the body’s hormones – the glucocorticoid receptor, and the alpha and beta thyroid receptors, the adrenal receptors, and the progesterone receptors, among others.

This means that when 1,25-D is high, it competitively displaces cortisol, T3, and other metabolites from their target nuclear receptors, causing havoc on the body’s hormonal pathways. Thus, most people with chronic disease find they have difficulty tolerating stress, changes in temperature, and a variety of other hormone-related issues. Also, when levels of 1,25-D rise above 42 ng/ml, calcium begins to be leached from the bones, a process that results in osteoporosis and osteopenia.

When 1,25-D rises due to the processes described above, it also binds a receptor called the PXR. The PXR subsequently inhibits conversion of pre-vitamin D to 25-D, causing 25-D levels to drop. This means that low levels of 25-D – the form of vitamin D measured by most doctors – is not a sign of vitamin D deficiency. Instead, low levels of 25-D are a result of the disease process.

The body also produces 1,25-D in response to sunlight on the skin and bright light in the eyes. Excessive exposure to these sources of light helps drive the disease process. Most patients on the MP must take certain precautions, described on the web site, to avoid too much sun/bright light.

The Treatment

Patients on the Marshall Protocol take a medication called olmesartan (called Benicar in the United States), which is able to bind and activate the VDR by pushing 25-D and bacterial proteins out of the receptor. Patients also lower levels of 25-D in the body by avoiding the kinds of vitamin D present in various foods. These measures renew the body’s ability to turn on the innate immune system and produce the anti microbial peptides. The immune system is then able to kill the Th1 pathogens and is once again able to manage viral and other co-infections.

At the same time, MP patients take pulsed, low-dose antibiotics. Antibiotics taken in this manner are much more effective against bacteria in biofilms and are able to greatly weaken the Th1 pathogens so that the patient’s own immune system is then able to destroy them. The antibiotics weaken the bacteria by blocking their ribosomes, which they need to produce proteins that help them survive and reproduce. It’s important to understand that when the Th1 pathogens die, there is a temporary change in a patient’s immunopathology.

Immunopathology refers to the changes in the immune system that result from bacterial death (another term sometimes used is the Jarisch-Herxheimer or “Herx” reaction). Dying bacteria release toxins into the bloodstream, stimulate the production of inflammatory cytokines, and generate temporary hormonal imbalances. This means that once patients begin the MP, each dose of antibiotic will cause them to feel bad for the period of time it takes their immune system to deal with the consequences of bacterial die-off.

Before starting the MP, many people may feel that they have improved through consuming vitamin D and taking steroids such as prednisone. In reality, these compounds further inactivate the VDR, preventing the immune system from effectively killing the Th1 pathogens. Since it is the death of these forms of bacteria that generates an increase in painful symptoms, people may experience short-term relief when using vitamin D or prednisone as their immune system shuts down and fewer bacteria are killed. However, in reality, this situation allows the bacteria to spread more easily.

Applicable Illnesses

Patients on the MP have dozens of different medical conditions. As evidenced by members’ reported progress on the marshallprotocol.com website, nearly all experience a powerful immunopathological reaction after taking a dose of antibiotics.

Many patients report great improvement, while some are approaching complete recovery.

Some of the diseases patients are currently using the MP to treat include (but are not limited to):

  • Sarcoidosis
  • Chronic Fatigue Syndrome
  • Fibromyalgia
  • Chronic Lyme Disease
  • Rheumatoid Arthritis
  • Multiple Chemical Sensitivity (MCS)
  • Myasthenia gravis
  • Psoriasis
  • Osteoarthritis
  • Hashimoto’s Thyroiditis
  • Uveitis
  • Cardiac Arrhythmia

Here is a more complete list of diseases.

Apart from the symptoms or diagnosis indicating Th1 disease, the easiest way to find out if the Marshall Protocol may be applicable to your disease is to get a blood test and check the level of your D Metabolites. This test can detect the elevated level of 1,25-D often seen in patients with chronic disease, but must be done correctly in order to be of any value.

Patients can also use a therapeutic probe to determine whether the MP can be applied to their illness. A therapeutic probe refers to a trial period during which a person tests whether or not the taking the MP medications results in immunopathology or other symptom changes.

Because patients must carefully manage their immunopathology, it takes several years to complete the MP. Severely ill patients may need 3-5 years to reach a state of remission. However, once on the MP, most patients begin to notice improvements little by little.

Patients must work with their own doctor while on the treatment, but receive guidance from the nurse moderators on the study site during the times when their doctor is not available.

Phase One Guidelines give detailed instructions regarding dosages, etc…. One must follow the guidelines carefully to avoid the risk of serious reactions from immunopathology reactions due to the bacterial killing.

Once patients interested in starting the Marshall Protocol have read as much information as possible about the treatment on this website and the study site itself, they are encouraged to ask questions about the MP at the website www.curemyth1.org. Questions are answered free of charge by patient advocates.

About Professor Trevor Marshall Ph.D.

Trevor Marshall, Ph.D., is a biomedical researcher. In 2002, Marshall published a pathogenesis for sarcoidosis followed in 2004 by the definitive paper in Autoimmunity Reviews “Sarcoidosis Succumbs to Antibiotics.” He has since written several papers and given numerous presentations that detail the pathogenesis of chronic disease. He has derived many of his findings by using molecular modeling.

Marshall is currently active on the medical conference circuit. Among his many endeavors, he was invited by the Food and Drug Administration (FDA) Center for Drug Evaluation and Review in March 2006 to give a presentation in their “Visiting Professor” lecture series. In 2006, he co-authored a book chapter about Vitamin D dysregulation. He recently chaired a session on vitamin D and translational medicine at the 2010 International Conference on Autoimmunity in Portugal.

Marshall has hosted two conferences on “Recovering from Chronic Disease,” the first in Chicago in 2005, and most recently in Los Angeles in 2006. In 2007, Marshall was appointed Adjunct Professor in the School of Biological Sciences and Biotechnology at Murdoch University in Australia.

Autoimmunity Research Foundation

The directors and members of the ARF work to:

1. educate doctors and patients about the Marshall Pathogenesis and Protocol.
2. communicate with researchers in the field of autoimmunity and Th1 disease.
3. run the MP’s study web sites, marshallprotocol.com and sarcinfo.com
4. gain FDA designation for medications used in conjunction with the MP

Visit the MP Knowledge Base, for a complete and up-to-date list of presentations by Amy and other members of the Autoimmunity Research Foundation team.

202 Responses for "About the Marshall Protocol"

  1. Claire August 24th, 2007 at 2:24 pm 1

    Thanks Amy, This is one of the most complete, yet easy to understand, explanations of the process that I’ve seen. Hopefully, it will cause some folk to look at the science behind the MP more carefully. Claire

  2. Bill March 6th, 2008 at 6:02 pm 2

    Amy; This indeed is the most complete and detailed explanation of the role of “vitamin D” involvementt in the inflammatory process that I have seen, including reading much of what is available on Marshall’s site and his DVDs. Now, how can I get the scientific references which support this vitamin D story? This query to Marshall’s site went unanswered. Thanks. Bill

  3. Amy Proal March 8th, 2008 at 2:05 pm 3

    Hi Bill,

    The following article, “The Truth About Vitamin D: 14 reasons why misunderstanding endures” has quite a few sources (nearly 100) at the end of the piece that support Marshall’s view on vitamin D.

    http://bacteriality.com/2007/09/15/vitamind/

    You should also read Dr. Marshall’s latest paper “Vitamin D discovery outpaces FDA decision making” that was recently published in BioEssays. Here a link to the full text:

    http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf

    By looking at the studies in the reference section of those two articles, you should be able to read most of the papers on which Marshall’s discoveries about vitamin D are based.

    Best,

    Amy

  4. Dena March 10th, 2008 at 2:47 pm 4

    How is this different from the Antibiotic Protocol for minocycline which many of us have found very helpful for various forms of inflammatory diseases? I am referring to Dr. Brown’s work as explained in “The New Artrhritis Breakthrough.” Information about this can be found on roadback.org.

  5. Amy Proal March 10th, 2008 at 2:50 pm 5

    Hi Dena,

    The Marshall Protocol is much different from the RoadBack protocol, which I am familiar with. For starters the MP uses five different antibiotics to target a much wider spectrum of bacteria then minocycline alone. These antibiotics are also taken 3 at a time in the later phases of the protocol. This means that they are better able to weaken the bacteria that cause inflammatory diseases by blocking more of their ribosomes, or proteins they use to replicate, glean energy etc.

    Another great difference between the MP and the RoadBack protocol is that the MP uses a medication called Benicar to activate the receptor that controls the activity of the innate immune system – the branch of the immune system that directly kills bacteria. Without this activation, the antibiotics have much less of an effect. Some people find they cannot even kill bacteria until they use Benicar to stimulate their immune system.

    Benicar also has multiple anti-inflammatory properties that allow it to palliative the inflammatory response that occurs when patients begin to kill bacteria and an immunopathological or herxheimer response is generated. This palliation allows people to better tolerate the herx and makes a big difference in keeping symptoms tolerable.

    So basically, the MP allows patients to kill a much broader spectrum of bacteria while also giving their immune system a much greater capacity to get the job done. Patients on the MP also avoid vitamin D, a secosteroid that blocks the ability of the innate immune system to function up to par. Since patients on the RoadBack protocol do not limit vitamin D intake or use Benicar to activate the immune system it is unlikely that patients on the treatment will be able to target pathogens as effectively as patients on the MP. With the above measures in place, the MP allows patients to completely recover because they are able to target all of the many different species causing their symptoms.

    The following article describes the MP in greater detail, explaining how Benicar and each of the antibiotics work at the molecular level. The article should make it clear where the MP differs from the Roadback Protocol.

    http://bacteriality.com/2007/10/11/antibiotics/

    Best,

    Amy

  6. Melissa Prara March 10th, 2008 at 6:19 pm 6

    Dear Sirs,

    As I sit here trying hard not to cry after reading myself on these pages; and, also trying to remember why I am writing you; oh, yeah! That’s it. Now I remember. I was diagnosed with infectious mono and CFS about four years ago. High EBV and HSV2 titers found in my spinal fluid; and by blood.

    I am currently taking 1 gram – 3 grams on valacyclovir per day (3 grams when flares occur).

    However, my cognitive abilities have declined steadily over the course of the past eight months or so.

    I go do see my doctor on March 20, 2008 to check in w/him.

    Is there anyone at your facility that my doctor can contact?

    I am very interested in finding out more. I would like to continue uphill; not decline cognitively. I am a professional-working, single mother that has a very long life ahead of her. Lastly, a 1.2 cm brain lesion was found on a regular CT; I was told the following: “well, melissa, God makes everyone special”. I never went back to get a follow up enhanced CT scan because all I could think was, “how frickin’ lame of an answer was that”. The only reason I had a CT done to begin with was because of a spider bite by my right ear and I contract a staph infection. Kripes, that was like last July, 2007 or something. The radiology report was indicative to obtain an ‘enhanced’ CT scan of my brain. Forget it. I don’t know the doctors in this small town know how to approach things like this. I think they are just scared.

    Imagine how I feel?

    Any advice or phone numbers in which my infectious disease doctor can reach you would be greatly appreciated. Thank you in advance for your time.

    Melissa P., Twin Falls, Idaho

  7. Amy Proal March 10th, 2008 at 6:20 pm 7

    Hi Melissa,

    Well, I can certainly understand why you are scared and upset about your health. It is scary that your doctors seem to have no idea about what is causing you cognitive decline, lesions and overall health problems.

    Although it has yet to be fully accepted by mainstream medicine, the molecular modeling research of biomedical Trevor Marshall has made it clear that chronic inflammatory disease is the result of infection. I have no doubt that the reason you have so many viral co-infections, cognitive issues, and a brain lesion etc, is because you are infected with L-form bacteria.

    L-form bacteria are bacteria that have mutated from classical forms of bacteria, lost their cell walls, and are able to live undetected inside the cells of the immune system. L-form bacteria also create substances that block the main receptor that controls the activity of the innate immune system. By doing this, they slowly shut down your immune system. Once a person’s innate immune system is no longer working up to par, they start to accumulate what we refer to as a “peasoup” of pathogens. Essentially the immune system is so weak that the body is easily infected by viruses, Candida etc. This is surely why you have high viral titers.

    Read more about L-form bacteria here:

    http://bacteriality.com/about-the-mp/

    And an interview with a researcher who works with them here:

    http://bacteriality.com/2007/09/09/markova-interview/

    The Marshall Protocol, the treatment discussed on this site, allows patients to effectively kill L-form bacteria, and it is the only treatment to date that can target these pathogens correctly. The treatment uses a medication that activates the innate immune system along with pulsed, low-dose antibiotics to gradually kill L-form bacteria. As L-form bacteria are killed, the immune system is able to function again. As it recovers, it is once again able to deal with viral and other co-infections, so that they no longer become a problem.

    Read more about the treatment here:

    http://bacteriality.com/about-the-mp/

    And here:

    http://bacteriality.com/2007/10/11/antibiotics/

    Patients on the Marshall Protocol also avoid vitamin D in food and supplements, because in reality, the substance is a secosteroid that slows the activity of the innate immune system much like the substances created by L-form bacteria. Read more about the new discoveries that have helped us understand these properties of vitamin D in this article:

    http://bacteriality.com/2007/09/15/vitamind/

    Also I think you will be interested in the following article which shows that people consuming high levels of vitamin D are at much greater risk for developing brain lesions. Since you are starting to develop a lesion I think it is of upmost importance that you begin to avoid vitamin D and start the Marshall Protocol. Here’s the lesion article:

    http://bacteriality.com/2007/10/24/brain_lesions/

    Finally, cognitive dysfunction is an incredibly common symptom in people infected with L-form bacteria. In fact, I will be presenting a presentation at the upcoming Days of Molecular Medicine Conference in Karolinska Sweden about cognitive dysfunction and chronic disease. The following article explains what I will be talking about. Some of the concepts may seem a little complicated, but overall I hope you can see that there is a tremendous connection between L-form bacteria and cognitive function.

    http://bacteriality.com/2008/03/09/cognitive-dysfunction/

    The good news is that you CAN turn around your health if your start the Marshall Protocol. As Dr. Marshall has stated often, we are finding that the brain has full capacity to heal. The treatment is difficult but absolutely worth it because it will allow you to recover your full health.

    There are other young mothers on the MP who have been able to do the treatment and still get by. Read about one here:

    http://bacteriality.com/2007/11/19/interview12/

    If you have more questions about the MP, how to find a doctor etc. the best place to ask them is at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by L-form bacteria, hence the name Cure My Th1). The patient advocates on that site, who volunteer for the non-profit agency that runs the MP, will answer your questions free of charge.

    Good luck!

    Amy

  8. CYNTHIA AUSTIN March 10th, 2008 at 6:24 pm 8

    How does one find a physician who is using this protocol? I have friends and familoy in the MPLS/St. Paul area whith severe CFS or Fibromyalgia.

  9. Amy Proal March 10th, 2008 at 9:02 pm 9

    Hi Cynthia,

    As you seem to realize, patients must work with their own doctor, although they are also encouraged to post on the Marshall Protocol study site so that the nurse moderators on the site can give them feedback about their progress.

    But your friends/family will definitely need a prescribing doctor. First off, you can request a list of doctors that have others patients on the MP in your area at this link:

    http://www.marshallprotocol.com/forum11/11348.html

    You may also want to get on the study site (www.marshallprotocol.com) and look for other people who live in the Minneapolis/St.Paul area and ask them who their doctor is. You can send them a private message through the website.

    If those options fail, then your best bet is to convince the current doctors of your friends/family or another a doctor in your area that seems open-minded to put them on the treatment (or obviously they can do the convincing themselves).

    Gina Riggio, a volunteer for Autoimmunity Research Foundation (the non-profit that runs the MP) has compiled a folder of study site information which is professionally formatted and designed to introduce the Marshall Protocol to an interested doctor.

    The documents are available to download free of charge if you would like to print them and put them in your own binder. Or if you don’t have a color printer, Gina will send you the complete folder of information thorough the mail.

    For details, visit this website: http://www.ginariggio.com/MP/phase1guide.html

    Also, be sure that you and anyone you know who would like to start the treatment read as much as you can about the Marshall Protocol both on this website and on the Marshall Protocol study site so that you can be prepared at your doctor appointment and explain in detail why you want to do the treatment.

    If you or your family, friends etc. have questions about the MP a good place to ask them is at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by L-form bacteria, hence the name Cure My Th1). The patient advocates on that site will answer about questions about the treatment and how to get started free of charge.

    Good luck and let me know if I can be of any other help.

    Best,

    Amy

  10. simon sanders March 17th, 2008 at 6:11 pm 10

    My partner has had RA for 23 years and is in a bad way. She has just started MMS. Does this do a similar job? http/www.mms-miraclemineralsupplement.com/
    Thanks
    Simon

  11. Amy Proal March 21st, 2008 at 11:57 am 11

    Hi Simon,

    The MP is not similar at all to MMS. In fact, patients on the MP do not take supplements unless they have a marked deficiency of a substance. Otherwise, supplements are avoided at all costs because they generally contain substances that may negatively affect immune function.

    The Marshall Protocol is based on research showing that inflammatory diseases like RA are actually caused by L-form and biofilm bacteria. L-form bacteria are bacteria that have mutated from classical forms of bacteria, lost their cell walls, and are able to live undetected inside the cells of the immune system. Read more about them here:

    http://bacteriality.com/2007/08/15/l-forms/

    And an interview with a researcher who works with them here:

    http://bacteriality.com/2007/09/09/markova-interview/

    The Marshall Protocol uses a medication that activates the immune system along with low-dose, pulsed antibiotics to gradually kill the L-form bacteria at the heart of diseases such as RA. When all bacteria are killed, the patient regains complete health.

    Read more about the Marshall Protocol here:

    http://bacteriality.com/about-the-mp/

    And here:

    http://bacteriality.com/2007/10/11/antibiotics/

    So the Marshall Protocol is not based on the idea that a person can use supplements to somehow “boost” systems of the body or artificially force the body have a certain level of a particular substance. Rather it targets the root cause of inflammatory disease, and by killing the bacteria responsible for dysregulating many of the body’s pathways, allows the body to naturally reach a state of homeostasis and wellness – no supplements needed.

    I hope you look into the MP in greater detail as the MMS supplements will only “cover up” or palliate your partners symptoms but not allow her to target the root cause of her illness.

    For example here is an interview with a man who used the MP to recover from RA:

    http://bacteriality.com/2007/09/01/interview2/

    If you have more questions about the Marshall Protocol, a good place to ask them is at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by L-form bacteria, hence the name Cure My Th1). The patient advocates on that site, who volunteer for the non-profit agency that runs the MP, will answer your questions free of charge.

    Best,

    Amy

  12. Tracey Holloway March 27th, 2008 at 5:44 pm 12

    Are there any doctors in the UK prescribing this regime?
    Thanks
    Tracey

  13. Amy Proal March 28th, 2008 at 10:43 am 13

    Hi Tracey,

    You can request a list of MP doctors in Europe and the UK at the following link from the Marshall Protocol study site. Here are the instructions:

    http://www.marshallprotocol.com/forum11/11348.html

    If none of the doctors on the list are taking new patients or none of them work near you, I recommend going to the Marshall Protocol study site and searching for other members on the treatment who live in the UK. You can them send them a private message and ask who their doctor is. Hopefully you might be able to set up an appointment with the same physician. Search for MP members in the UK at this link:

    http://snipr.com/mpunitk

    If after the above efforts you still can’t find a doctor, post about your situation at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by L-form bacteria, hence the name Cure My Th1). The patient advocates on that site, who volunteer for the non-profit agency that runs the Marshall Protocol, will give you further advice on how to find a doctor.

    Good luck!

    Amy

  14. Lucille White April 7th, 2008 at 8:40 am 14

    I have been diagnosed with Sarcoid and waiting for an appt. with the University of Washington because I refuse to go on Predisone. I have known I have had this since 1995 but went untreated, now I am nearing the fourth stage. I have been reading up on this and found MP, is there a Dr. in Wa. that will work with me?

  15. Amy Proal April 7th, 2008 at 11:12 am 15

    Hi Lucille,

    Good for you for refusing to go on prednisone! That decision has almost certainly slowed the progression of your disease. Prednisone and steroids work only by slowing the immune system. Since we now understand that sarcoidosis is a bacterial illness, predinsone slows the rate of bacterial death and subsequently the elevated immune response that accompanies it (immunopathology). But since the immune system is slowed, the bacteria at the heart of the disease have a field day and are able to spread to new tissues and organs.

    It sounds like you understand that the MP is the only curative treatment option for sarcoidosis and I’m so glad you are looking for a doctor that will put you on the Marshall Protocol.

    Here are two suggestions that should help you find an MP doctor.

    First, you can request a list of doctors who are already working with MP patients in Washington state. Because they already have patients on the treatment, they should be willing to take you on as a patient as well. You can request that list at the following link:

    http://www.marshallprotocol.com/forum11/11348.html

    Also, I recommend that you go to the Marshall Protocol study site and click on the “members” button in the upper right hand corner. There, you are given the option of searching for information on every patient on the MP based on their location. Look for other patients in Washington state. Then send them a private message over the board asking them who their doctor is, if they can provide contact information, and if they are happy with him/her. I find that this method of contacting MP patients in you state directly is a great way to find a doctor.

    If you still can’t find a doctor after taking the above steps you can try to convince you current doctor or the doctor at the Univeristy of Wa. to put you on the MP. There is information about the Marshall Protocol to present to doctors on the study site. For example, here is a packet of information that you can download, print and show to a doctor.

    “Folder of MP information to present to your doctor”

    http://www.marshallprotocol.com/forum11/11348.html

    Good luck!

    Amy

  16. Martin Babb April 11th, 2008 at 1:22 am 16

    Hi Amy:

    I’m in Seattle and have been on the MP for 2 1/2 years now with remarkable results. I had a less- than- helpful experience at the University of Washington before finding the MP and would like to make myself available to Lucille (above) if that is ok with you. I know of two doctors here in the Puget Sound who administer the MP whom I can highly recommend.

    Regards and thanks for your work.

    Martin

  17. Amy Proal April 11th, 2008 at 9:00 am 17

    Hi Martin,

    I’m so glad you are doing well on the MP and that have found a good doctor! I will send you Lucille’s email address. Hopefully you can then contact her and give her more information about your doctor.

    Thanks for posting!

    Amy

  18. Matt April 11th, 2008 at 6:53 pm 18

    Hi Amy,

    I have suffered from CFS for 18 years since the age of 11. I have many infections with the most severe being Intestinal yeast overgrowth (diagnosed through stool sample, blood ethanol post glucose challange, and liver enzymes showing patterns associated with alcohol related pathology – I have not drubk for 10 years!). I also have severe S.A.D. as part of my illness.

    While the Marshall Protocol makes sense to me as you explain it I am left with a conundrum. Without exposure to bright light and sunlight on my skin I feel SUICIDAL. It was only through the realisation that a lack of sun exposure was causing my severe deppression that I am here typing to you today as I could not have survived another winter otherwise.

    So I am left thiking, yes this Marshall Protocol seems to make sense, but in the context of my own illness there would seem to be no way I could implement it. I’m sure you are aware of the studies that show vitamin D from both sun exposure and supplements is a highly effective anti-depressant, particularly for seasonal forms.

    What is your take on my situation?

    Thanks, Matt

  19. Amy Proal April 12th, 2008 at 10:47 am 19

    Hi Matt,

    I also had terrible Candida overgrowth before starting the Marshall Protocol. I was constantly taking antifungal medications which would help for a few weeks (with a horrible die-off!), only to have the Candida return again. It was terrible. But since the Marshall Protocol restores immune function by using the medication Benicar to activate the main receptor that controls the activity of the immune system, I have not suffered from any symptoms of Candida since starting the treatment. It’s great!

    But you seem most concerned about the sun issue. Yes, I am definitely aware of studies showing that sunlight makes people, particularly those who have some form of chronic disease, feel better. That’s because those studies directly support the Marshall Protocol disease model.

    The reason that you feel better in the sun is because excessive sun exposure causes levels of both forms of vitamin D to rise substantially. The precursor form, called 25-D, is a secosteroid. When it rises to high levels, it blocks the Vitamin D Receptor (VDR) – the receptor I mentioned above that controls the activity of the innate immune system. So excessive sun exposure causes 25-D to rise to a level where it turns the VDR and subsequently innate immune function off.

    Sun exposure also causes the active form of vitamin D, 1,25-D, to rise. When 1,25-D becomes too high, it binds a set of important receptors called the nuclear receptors and displaces the metabolites that are supposed to activate them from the receptors. Since these receptors transcribe natural antibiotics created by the body called antimicrobial peptides, the actions of 1,25-D on the nuclear receptors cause the production of the antimicrobial peptides to slow.

    Together these two processes mean that people become severely immunosuppressed when they are getting high levels of sun. Their innate immune systems and the antimicrobial peptides are no longer working, meaning that the bacteria at the heart of their disease are able to spread with much more ease. The immune system is so weak that it hardly kills any bacteria anymore, whereas during the winter it had the strength to target many more of the pathogens.

    So high levels of sunlight make you feel better because it is the DEATH of L-form bacteria that causes people to feel bad. It’s when they die that the body must deal with the toxins they once harbored, the cellular debri from the cell they once infected, and the inflammatory response by the immune system in response to their death.

    So what the sun is doing is quelling this die-off reaction. You feel better, but you are not getting better.

    I used to be just like you. My only relief from my CFS was the sun. When I was forced to live with my parents because my CFS essentially made me bedridden around age 21, I moved in with them at our house in Mexico City. Instead of being bedridden in my bed, I lay outside in the sun from morning ’til night until I had the darkest tan imaginable. I felt so much better that I started walking again, even doing mild exercise. I thought I was improving.

    Then I went back to the US where it was still dark. Several weeks later I started to feel terrible. I went to sleep one night and woke up feeling horrible in a way I simply cannot put into words. I was even sicker then when I had been bedridden before. At that point I realized that something about the sun had actually made me much worse. Now I understand that the sun was just slowing my immune system and my rate of bacterial death, but it was only temporary palliation.

    So unfortunately, mainstream doctors, who don’t understand that CFS and other inflammatory diseases have a bacterial cause mistakenly think that the feeling of “wellness” many ill patients get in the sun is a good thing. It’s actually a very bad circumstance.

    You are young and you need to treat your CFS with the MP. It is the only curative option for the disease and it works. I cannot tell you how much better I feel today and I am completely confident full recovery is on the horizon. So what can you do in order to manage not being in a lot of sun?

    Do you take antidepressants? Antidepressants are not contraindicated by the MP if a patient really needs to take them. I know you may not want to take an antidepressant, but if it could mentally allow you to tolerate less light exposure in order kill the bacteria making you sick, I feel it would be worth it.

    Also, you can do everything in your power to not feel cooped up in the dark. At the start of the treatment I found that once it became dusk, the sun no longer affected me. So I would make sure to go outside at that time, watch the sun set, and then do something outside (maybe just sit!) for the rest of the night, just to get out of the house.

    Everyone’s level of light sensitivity varies. You may not become severely light sensitive and maybe you will be able to tolerate going out during the day as long as you are covered up in dark clothing and wearing sunglasses. Sure, you might look weird, but who cares? The important thing is that mentally you feel that you are not always in the dark.

    Also, sunscreen zinc oxide is able to block some of the production of vitamin D from sunlight in the skin. If you slather yourself in zinc oxide sunscreen every time you go outside you may be able to tolerate some more sun.

    Those are my main suggestions. All I can say is that it’s worth trying everything in your arsenal – any drug that could help you manage your symptoms of SAD, anything so that you can get through the MP. Because you are young and have a full life ahead of you if you do get through the treatment.

    Also, if you can just get through the first year and a half or two years of the MP, light sensitivity really improves. It gets easier and easier, so only the first year or so should be really tough.

    You may also want to post about your situation at the following website:

    http://www.curemyth1.org (Th1 refers to disease caused by L-form bacteria, hence the name, Cure my Th1). The patients advocates on that site, who answer questions for free, may be able to give you further advice.

    Good luck!

    Amy

  20. Kimberley April 13th, 2008 at 6:47 pm 20

    Hello Amy — I’ve spent the last few hours reading your wonderfully detailed site with fascination. I suspect I have Chronic Fatigue Syndrome but can’t find a physician who will deal with it.

    I was looking for a link on this site on “How to find a physician who will listen” :-) but, not finding one, could you please advise?

    What type of physician or specialist should I look for who most likely will understand CFS, and test me for it? (Once that diagnosis is made, then I’ll proceed with MP.)

    Thank you for any “first step” information you can provide. I very much appreciate your and Dr. Marshall’s and everyone else’s research, and this fine, easily accessible and understandable website!

    Best wishes,
    Kimberly

  21. Amy Proal April 13th, 2008 at 6:48 pm 21

    Hi Kimberly,

    I’m so glad that you can relate to the articles on this site and that you seem to realize that the Marshall Protocol is the only curative treatment for CFS.

    You are in a good place to start the treatment. Most people to start the MP with CFS have been sick for 20-30 years and their bacterial load is very high. But if you haven’t even been diagnosed yet, then I would say your bacterial load is lower. Perhaps then, your immunopathology will be easier to tolerate, you may not become too light sensitive, and you may progress through the treatment faster than some of the sicker CFS patients. Of course, I don’t know the extent of your symptoms, but starting the MP as soon as possible is always a good thing.

    The best way to find a physician who will put you on the Marshall Protocol is to first request, from the Marshall Protocol study site, a list of doctors in your area who already have patients on the MP. You can request the list here:

    http://www.marshallprotocol.com/forum11/11348.html

    If none of the doctors on the list will take you as a patient or do not practice near you, then I suggest that you look for other people on the MP who live in your area and find out who their doctors are. Go to the MP study site and click on the “members” button on the right upper part of the screen. Then click on “location.” Members of the site will then be listed depending on where they live. Scroll through the list until you find people who live near you, then send each person a private message asking them who their doctors is and if you can have his/her contact information.

    If that doesn’t pan out then you will have to present to Marshall Protocol to a doctor. Do you already have a doctor? If you don’t a general practitioner might be more open to the MP than a specialist but there is no real way of telling. Perhaps you can ask around for word of an open-minded doctor in your area who is willing to try new treatment options. You can present such a doctor with the following booklet of information. You may also want to print out articles from this site for him/her to read:

    “Folder of MP information for your doctor”

    http://www.ginariggio.com/MP/phase1guide.html

    You may also want to show a potential doctor Dr. Marshall’s latest paper on vitamin D that was published in BioEssays. Here is the link:

    http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf

    I would try to find only one doctor- one who will diagnose you and put you on the MP. There are no tests for CFS. The diagnosis is made only on the basis of symptoms. If you feel fatigued and as if you have symptoms of CFS then you already know you are chronically fatigued and that the Marshall Protocol will get you back in shape. So I would suggest looking for an MP doctor right away – someone who will already understand that concept.

    So those are my suggestions. If you have more questions about how to find a doctor or want another opinion, a great site to ask questions at is:

    http://www.curemyth1.org (Th1 refers to diseases caused by L-form bacteria, hence the name Cure My Th1). The patient advocates at that site, who volunteer for the non-profit organization that runs the MP, will answer you questions free of charge.

    Good luck and I hope to see you on the study site in the months to come!

    Amy

  22. Kimberley April 14th, 2008 at 7:51 am 22

    Amy, thank you so much for your quick and informative reply! Yes, after reading through the site, I feel very fortunate not to be as sick as so many others. In fact, I never knew CFS could make one THAT sick — it’s shocking. I’m anxious to get started. Thank you VERY much!
    Kimberly

  23. christopher jeffries April 19th, 2008 at 7:02 am 23

    Hi,
    I am a chronic prostatitis sufferer currently in China receiving interprostatic injections of antibiotics to try and kill my deep-seated pathogens. This is my second visit to China. My first visit resulted in a relapse after 3/4 weeks of returning home to the UK.

    Are you currently doing any research on chronic prostatitis, which seems a disease ready-made for the Marshall protocol.
    Regards
    Chris Jeffries

  24. Amy Proal April 21st, 2008 at 2:14 pm 24

    Hi Chris,

    Sorry not to respond to you question more prompty. I’ve been in Sweden for a medical conference this past week.

    As far as I know, Dr. Marshall has not done any specific work on chronic prostatitis. That is because we are finding that although each chronic condition manifests with different symptoms, they all have the same underlying pathogenesis, namely infection with Lform and biofilm bacteria. Now that Dr. Marshall has established the pathogenesis, it seems to apply to people with nearly every chronic condition.

    I can tell you that Gerald Domingue, a researcher who work for years at Tulane University investigating the Lforms found large numbers of the pathogens in the kidneys, urogenital organs, and in urine. If the pathogens are found in urine, there’s a pretty big chance they can also infect the prostate.

    So I agree with you that the MP is a treatment ready made for chronic protatitis. The MP is a treatment ready made for any chronic condition that mainstream medicine considers to be of unknown cause that involves inflammation and pain.

    Soon, Dr. Marshall and Autoimmunity Research Foundation plan to do studies that will definitively prove that Lform bacteria can exist in nearly every tissue of the body, hopefully by doing single cell DNA sequencing where pathogenic DNA can be identified.

    In the meantime, people with an incredible array of chronic conditions are starting the Marhall Protocol and we essentially have an 100% response rate to the treatment. That means that people with a great variety of diseases are all experiencing immunopathology in response to the MP antibiotics and Benicar. I have little doubt that chronic protatitis will respond as well. So I encourage you to start the MP now, even if there are no definitive studies on the MP and protatitis.

    Also, it is very likely that many of our male patients do suffer from protatitis along with their other chronic conditions. Some men may not be comfortable talking about it in an open forum, but I’m sure there are already men on the MP with the condition, some likely recovering. It’s been very hard for me to follow the progress of new patients on the MP since so many new people are starting each day. But I encourage you to get on the study site and look at patient’s signature lines where they list their conditions. You may very well find others with chronic protatitis. You can send such a person a private message over the board and ask them about their experience with the MP.

    However, the best way to figure out if your condition will respond to the MP is to do what is referred to as a therapeutic probe. That simply means that you could start Benicar and then low dose minocycline and see if you get a rise in your protatitis symptoms (immunopathology). If you do, you are almost certainly killing bacteria in the area, and if you are killing bacteria in the area, you will almost certainly repond and recover with the MP.

    I’m sorry to hear about your relapses after usiing high dose antibiotics. Unfortunately, antibiotics have negative effects on immune function along with their antibacterial properties. So if they are administered in high doses they only act as a palliative. They actually slow the rate of bacterial death, allowing the patient to feel better. But as you are well aware of, when patients stop the antibiotics the palliative effect stops and relapse is inevitable.

    That’s why the MP uses very low, pulsed antibiotics. The doses are so low that the antibiotics still effectively weaken Lform bacteria but do not affect the immune system. I think you will see that you would respond very differently to low, pulsed antibiotics than the antibiotics you were administered in China.

    So I highly encourage you to give the MP a try. If you have more questions about the treatment, a great place to ask them is at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by Lform bacteria, hence the name Cure My Th1). The patients advocates on the site, who volunteer for Autoimmunity Research Foundation, will answer your questions free of charge. The advocates may also be able to refer you to other patients already on the treatment who have chronic prostatitis.

    Good luck and I hope to see you on the MP board in the months to come!

    Best,

    Amy

  25. Bethany Keddy April 22nd, 2008 at 2:26 pm 25

    Hi Amy:

    Right after I sent my message to you, I found this link on the Autoimmunity Research site:

    http://autoimmunityresearch.org/hormones-bw.pdf

    It gives me a little more insight into how 1,25-D is connected to numerous hormonal pathways in the body. But it is somewhat vague,in saying hormonal “changes” resulting from “changes” in 1,25-D.
    The use of the word “changes” is not clear. Exactly what changes?!

    Maybe science does not yet fully understand all these pathways and impacts…???

    I assume that too much 1,25-D is a huge factor in messing things up!

    Also,

    I have a question re: your web page on “Cognitive dysfunction in women.”

    In the “Response” section following the article, you reply to someone named
    Lottis in entry number 12. You write this statement:

    “As all three processes cause the amount of 1,25-D to rise to an unnaturallyhigh level, the master hormone can no longer correctly regulate the thyroid, stress and sex hormones.”

    My question is:
    What is the master hormone?

    I am wondering if you meant to say the “master gland”…???

    It is certainly known, based on research, that the hypothalamus-pituitary-adrenal axis becomes dysfunctional in CFS. The feedback loop among these
    glands gets out of whack.

    (Some people refer to the hypothalamus as the master gland, while others consider the pituitary to be the master gland.)

    I will appreciate it if you can clarify this for me — re: master hormone.

    Thanks.

    Bethany

  26. Amy Proal April 22nd, 2008 at 2:30 pm 26

    Hi Bethany,

    The molecular mechanisms by which the Th1 pathogens are able to disable the body’s hormonal pathways are very clear. As patients accumulate a Th1 bacterial load, substances created by the bacteria begin to block the Vitamin D Receptor, slowing the innate immune response.

    When the VDR is block by bacterial substances or 25-D it can no longer transcribe an enzyme (CYP24A1) that is supposed to keep the body’s level of 1,25-D in the correct range. At the same time, the cytokines released by the Th1 pathogens over-activate an enzyme called CYP27B1. CYP27B1 controls the amount of 25-D converted into 1,25-D. When the enzyme is produced in greater quantities, more 25-D is converted to 1,25-D. Both processes described above cause 1,25-D to become elevated in patients with chronic disease.

    Unfortunately, when 1,25-D reaches a high enough level it is able to bind the body’s other nuclear receptors. The nuclear receptors are essentially the receptors that control the body’s hormonal pathways – the alpha/beta thyroid receptors, the androgen receptor, the progesterone receptor, the estrogen receptor etc. In his latest BioEassy paper, Dr. Marshall gives the exact affinities of 1,25-D for many of the nuclear receptors and shows that at high levels it is able to bind them quite easily.

    When 1,25-D binds these receptors, it displaces the metabolites that are meant to be in the receptors under normal conditions, metabolites that allow the hormonal pathways to run correctly. So when 1,25-D displaces these metabolites the patient experiences hormonal havoc. Essentially every hormonal pathways is affected, especially in people who are very sick.

    The MP kills the Th1 pathogens and removes 25-D from the diet which reduces blockage of the VDR and allows 1,25-D to gradually return to a normal range. As this happens, the patient’s hormonal problems generally begin to clear up. In the meantime, the immunopathological reaction can cause 1,25-D to rise at certain periods which is why IP often temporarily exacerbates hormonal problems.

    I have recently changed the wording in my “About the MP” article to make the above information more clear. When I previously referred to 1,25-D as the body’s master hormone I was referring to the fact that 1,25-D is a hormone. Actually 1,25-D can function as both a hormone and a secosteroid. But by calling it the master hormone, I was referring to the fact that it is probably the most important hormone in the body because it has the ability to bind, control, and adjust all other hormonal pathways through its actions on the nuclear receptors.

    Hope this helps!

    Amy

  27. Bethany April 22nd, 2008 at 4:47 pm 27

    Amy:

    Once again, I appreciate your response. Thanks for taking the time to address each person’s question with tremendous detail.

    For me, the “vitamin” D connection is the hardest part to understand about the Marshall Protocol — very complicated. Slowly but surely, I am understanding it more clearly — thanks in large part to your explanations.

    Be well!

    Bethany

  28. Sarn May 9th, 2008 at 12:50 am 28

    Hi – could you tell me if the marshall protocol is available in New Zealand? thanks

  29. Amy Proal May 9th, 2008 at 10:56 am 29

    Hi Sam,

    Yes, people in New Zealand can definitely do the Marshall Protocol (MP). The MP is a phase II open-based internet trial. So, patients work with their own doctor who prescribes the MP meds. Then, they write a weekly progress report on the MP study site, which allows their data to be collected as part of the study.

    Posting on the study site means that your progress will also be carefully monitored by nurse moderators. There is no charge for their service and you can ask them any questions about how to manage your medications and immunopathology at any time.

    So, in order to start the MP you essentially need to find a doctor in your area who is willing to put you on the treatment.

    You can request a list of MP doctors in New Zealand who already have patients on the Marshall Protocol at this link:

    http://www.marshallprotocol.com/forum11/11348.html

    Also, I recommend getting on the Marshall Protocol study site (www.marshallprotocol.com) and clicking on the “members” button on the upper right had part of the screen. There you can search for members by location. Look for other members who live in New Zealand and send them a private message over the site asking who their doctor is and what his/her contact info is etc.

    Also, you can present many of the resources on this site and on the MP study site to your current doctor and convince him/her to prescribe you the MP meds. Just for starters, here is a link to an MP presentation book for doctors:

    http://www.ginariggio.com/MP/phase1guide.html

    If you still can’t find a doctor, then be sure to post about your situation on the following website:

    http://www.curemyth1.org Th1 refers to diseases caused by L-form bacteria, hence the name Cure My Th1. You questions about doctors or any other issue related to the MP will be answered free of charge.

    Good luck!

    Amy

    PS. Here is an interview with a man who lives in New Zealand. He used to MP to recovery from sarcoidosis, psoriasis, and severe insomnia:

    http://bacteriality.com/2007/08/10/interview1/

  30. clare May 11th, 2008 at 9:12 pm 30

    I’ve been diagnosed with sarcoid due to symptoms of sob upon exercising. I’m taking an inhaler twice a day. It seems to help a little bit. How do you determine what stage your in.

  31. Amy Proal May 13th, 2008 at 5:06 pm 31

    Hi Clare,

    The MP is a treatment is based on the new understanding that sarcoidosis is a bacterial disease. It is caused by a wide array of chronic ideopathic bacteria, including L-form bacteria. Read more about L-form bacteria here:

    http://bacteriality.com/2007/08/15/l-forms/

    To date, the MP is the only curative treatment for sarcoidosis. Other treatments, like your inhalers are only masking your symptoms temporarily but not making you better. In fact, you inhalers may actually have steroids that are slowing your immune system and allowing the bacteria causing your disease to spread. So it is very important that you learn as much as possible about the Marshall Protocol, discuss it with your doctor, and start to eliminate the bacteria causing your illness.

    Patients on the Marshall Protocol work with their own doctor who prescribes the necessary medications. However, they also post their symptoms in weekly progress reports on the Marshall Protocol study site where they get free 24/7 feedback from nurse moderators.

    The following article describes the MP in greater detail:

    http://bacteriality.com/2007/10/11/antibiotics/

    The treatment is run by Autoimmunity Research Foundation. Here’s the link to their website:

    http://www.autoimmunityresearch.org

    The Marshall Protocol study site address is:

    http://www.marshallprotocol.com Be sure to read as much information about the treatment on the study site as well as on this site.

    Finally, you can ask questions about the MP, how to get started, etc at the following website:

    http://www.curemyth1.org Th1 refers to diseases caused by bacteria hence the name Cure My Th1. Your questions will be answered free of charge by patient advocates.

    I have to warn you that admission to the study was just closed due to the fact that too many people want to participate in the study and Autoimmunity Research Foundation does not have enough staff to accommodate the current boom in patients. However, on curemyth1.org you can ask the patient advocates how to get on a waiting list that will allow you to start the treatment when a spot opens up which may not be that far away.

    Even if you can start right away I recommend you go to curemyth1.org and sign up now. This is a curative treatment and the only treatment at the moment that can truly reverse sarcoidosis. There are currently hundreds of patients with sarcoidosis recovery thanks to the MP. Interviews with some of them are available on this site.

    The MP is composed of three phases. Patients in each phase take different antibiotics. The following video offers a full overview of the MP. I highly recommend you watch it. It will explain the different phases of the MP in greater detail.

    http://bacteriality.com/2008/05/07/mpintro/

    Good luck!

    Amy

  32. Lu May 23rd, 2008 at 2:52 am 32

    Hi – Could you tell me whether the Marshall Protocol is used in South Africa?

  33. Amy Proal May 23rd, 2008 at 11:29 am 33

    Hi Lu,

    Patients anywhere in the world can do the Marshall Protocol as long as they find a doctor in their area who will prescribe them the necessary MP medications.

    One of the MP medicines is an ARB called Benicar. I’m not sure if it’s available in South Africa, but if it’s not, you can probably find a way of importing it in from another country such as Germany or India.

    The way the Marshall Protocol study works is that each patient works with their own doctor. However, they also become a member of the Marshall Protocol study site (www.marshallprotocol.com) where they start a progress report. By posting about their symptoms in the progress report, they get free advice from nurse moderators who help guide them when their doctor is not available. Also, the symptoms they report become part of the study data.

    So to start the MP you must do two things. You must find a doctor in your area willing to put you on the treatment, and you must sign up to become a member of the study.

    You can sign up to join the study at the following webiste:

    http://www.curemyth1.org (Th1 refers to illnesses caused by bacteria, hence the name Cure My Th1). The patient advocates will give you an MP application form. At the moment, there is a waiting list to start the treatment because of the fact that so many patients want to start it but the site’s resources are limited. So make sure you fill out an application form as soon as possible so that you will get into the study as soon as possible (people are admitted off the waiting list on a regular basis).

    The patient advocates can also give you more detailed advice on how to find a doctor. There is no charge for their help.

    Good luck!

    Amy

  34. stella voisey May 27th, 2008 at 6:52 pm 34

    hi Amy

    Can you tell me if everyone who does the MP has light sensitivity?

    How long does it last on average?

    Would be the most difficult area to deal with.

    stella

  35. Amy Proal May 28th, 2008 at 6:53 pm 35

    Hi Stella,

    Light sensitivity varies greatly from person to person. The extent to which a person becomes light sensitive seems to correlate in most cases with their bacterial load. Those people with more bacteria generally suffer from greater dysregulation of the vitamin D metabolites, which causes them to have more problems dealing with light.

    In all cases though, light sensitivity does improve as a patient kills their bacteria, so that at the end of the MP the patient is no longer light sensitive.

    Some people find light sensitivity hard to deal with while others don’t. If you have to work, it’s going to be a bigger issue because your environment at work may be bright and your co-workers may not be able to change the environment for you. The same goes for people who have to travel or be in school and find it very hard to block light.

    But if you spend most of your time at home, it’s easier to keep light at a dimmer level. Yes, it hard not to be able to go to the beach or to have to wear glasses in the supermarket and possibly get strange looks from others, but in my opinion, recovering from your disease is worth any of the extra inconveniences that blocking light causes.

    At least in my case, blocking light didn’t bother me too much as I knew that I was getting better and that mattered to me more than being in bright light.

    This piece describes light sensitivity in greater detail:

    http://bacteriality.com/2008/02/23/misconceptions/#8

    Best,

    Amy

  36. Krista May 31st, 2008 at 10:12 am 36

    Hello Amy !
    Thanks for sharing your knowledge/experience with the benefit of MP on CFIDS. Halleluyah for you !!
    I have lived under the cfids/fm label for years. I was sent Dr Marshall’s dvd recently. I am open to trying it, I just don’t want to suffer from extreme canida because it ends up making me pretty miserable and depressed, if allowed to get severelly out of hand. I am someone who has had extreme problems with vaginal candidiasis every time I did short antibiotic runs for various infections in the past. I started the MP antibiotic protocol and am already itching after four days. Has anyone ever used any oreganol, colloidal silver,antibiotic alternatives etc with the benecar to kill the bacterial overgrowth?
    Thanks for your input.
    May today be a good energy day for you, Amy !

  37. Amy Proal May 31st, 2008 at 10:18 am 37

    Hi Krista,

    Hope today is a good energy day for you too!

    It’s odd that you would be dealing with symptoms of Candida when the vast majority of people with Candida who start the MP find that it clears up almost immediately because of the fact that Benicar activates the immune stem which is finally able to keep Candida under control.

    I certainly know that I suffered from massive issues with Candida before I started the MP, but as soon as I started Benicar they essentially cleared up and now are completely gone.

    In my opinion, what you think is Candida may actually be a species or several species of the chronic, intraphagocytic bacteria that cause
    CFS. If the symptoms of what you are used to attributing to Candida have flared thanks to the MP antibiotics, then what you are experiencing is almost certainly a bacterial die-off reaction or
    immunopathology – especially since these bacteria definitely cause symptoms of depression and itching.

    Think about it. Your doctor may have told you that the itching, depression etc. that your suffer from is caused by Candida, but now that you are aware of Dr. Marshall’s research, you understand that
    there are a vast number of bacteria causing your disease that your doctor was not previously (and may still not previously be aware of).

    So I’m pretty sure that what you are experiencing is a normal bacterial die-off reaction and that unfortunately, like anyone who starts the MP, you are going to have to deal with a rise in these
    symptoms of itching, depression etc as you kill the pathogens causing the issue.

    I would definitely not try to palliate the response with any other sort of medication as the medications or supplement may very well have negative effects on the immune system.

    When it comes down to it, even if your symptoms are related to Candida, once on the MP, a rise in symptoms signifies that you are killing the pathogen that causes the symptoms. So your rise in symptoms would then be a sign that you are killing Candida, something that you must deal with in order to recover.

    Are you a member of the MP study? Do you have a progress report on the site? If so, ask the board moderators what you could possibly use to at least get some relief from the itching.

    If you are not a member of the MP study I highly warn against doing the MP without being a member of study site where your progress can be monitored. Your current situation is probably just many of the issues that you will encounter as you progress through the MP. So you need the help of the trained staff who run the study to correctly manage
    your reactions.

    In order to get into the study, post about your reactions at http://www.curemyth1.org and you can get on a waiting list to be officially accepted into the study. There is no charge to be a member of the study.

    Best,
    Amy

  38. Annie June 2nd, 2008 at 12:26 pm 38

    Hello – I’ve noticed the Phase II and III trials are now closed. After we complete Phase I with our physician (if I can even find one to work with me) how do we start the next phase if the trials are closed (including the information on the boards).

    - Annie

  39. Amy Proal June 3rd, 2008 at 9:22 am 39

    Hi Annie,

    Yes, it’s unfortunate that the study is closed, but the moderators could no handle the great number of patients who all wanted to join the study at once.

    Technically, you are not supposed to do phase 1 alone with your doctor. It is expected that you will become part of the study and report your progress on the study site during phase 1 as well as during the other phases.

    Right now, there is a waiting list for the study and the moderators are gradually letting people into the study off the list.

    You can request the list at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria, hence the name Cure My Th1). The patient advocates on the site should tell you what forms to fill out to apply to become part of the study. If you already have a doctor that is willing to put you on the MP, you will probably be admitted more quickly.

    It’s important for you to officially join the study because the phase II/III guidelines are only given to study members by the moderators. You will not have access to them if you arn’t part of the study, and the guidelines must be followed very carefully so there’s no way to improvise.

    So post on curemyth1 as soon as possible.

    Good luck!

    Amy

  40. Sarah June 29th, 2008 at 10:03 am 40

    Hi Amy, I was diagnosed in June 2007 with atypical sarcoidosis in my lymph nodes. After 2 yrs of having swollen lymph nodes in my neck.(I also have a small node in my lower right lung.) My 7th doctor put me on daypro to help with the joint and muscle pain, my 8th doctor put me on prednisone 5mg a day. I still take the daypro b/c w/out it I couldn’t function in daily activities b/c of the pain. I no longer take the prednisone b/c of the weight gain, and I am already overweight. I have no idea what to expect and I have very little knowledge of this disease. The more I read on the internet the more terrified I am of what will happen. Until today on this site, I have found hope that I too can beat this disease. I live in the country of WV where our doctors have little knowledge of sarcoidosis, I am a working mother/wife supporting my family the best I can. I have no insurance and no way in sight of getting any. I see my pulmonary dr. every 6 mos for consultation to discuss my progress/regression and to refill prescriptions. Any advice you can give me will be greatly appreciated. I want a healthy life so I can grow old with my daughter. I am missing so much fun with her due to the pain….

  41. Amy Proal July 1st, 2008 at 2:57 pm 41

    Hi Sarah,

    I absolutely understand why anyone not familiar with the Marshall Protocol would feel terrified about the implications of sarcoidosis – considering the fact that it is a serious bacterial illness and much of mainstream medicine is simply not aware of the latest research showing how it can be effectively treated. However, the Marshall Protocol effectively reverses the disease and you can hopefully begin the treatment soon as possible in order to get your life back.

    Doing the MP does require a large commitment. You have to be willing to deal with immunopathology, avoid light to a certain extent if necessary, and of course change your diet to avoid vitamin D.

    But the ability to recover and spend quality time with your children will result if you stick with it.

    Read as many of the articles on this site as you can in order to become as familiar as possible with the treatment. Then, also be sure to familiarize yourself with as much information as possible on the study site itself – http://www.marshallprotocol.com. Doctor Marshall’s published papers and conference presentation abstracts/videos are also available on http://www.trevormarshall.com.

    If, after that, you have more questions about the treatment (how to get started, how to find a doctor) the best place to post them is at the following website:

    http://www.curemyth1.org Your questions will be answered free of charge by experienced patient advocates.

    Good luck!

    Amy

  42. Lori July 2nd, 2008 at 10:40 pm 42

    How do I get started?? I’ve been struggling with CFS for over 10 years and getting worse as I’ve gotten older. Doctor’s don’t know what to do with me and I am loosing everyone around me. Please help

  43. Amy Proal July 3rd, 2008 at 12:37 pm 43

    Hi Lori,

    I’m very sorry to hear about your struggle with CFS. I know how devastating the diseases can be. But the Marshall Protocol will allow you to kill the chronic bacteria causing the illness and effectively reverse your disease.

    If you want to start the treatment, a good first step is to read as much information about the MP on this website and on the study site itself – http://www.marshallprotocol.com. That way you will be able to best discuss the MP with your doctor and with the study site moderators.

    Next, post about your desire to start the Marshall Protocol at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria, hence the name). The patient advocates on the site will answer your questions about the MP in greater detail and there is no charge to use their services.

    Unfortunately, the study is closed at the moment to new patients. However, you can fill out an application to get on the waiting list to be admitted. But don’t panic if you can’t get into the study right away. As long as you have a doctor who is willing to prescribe you the MP medications you can do the MP along with his/her guidance without being an official member of the study.

    So the next step would be to educate your doctor about the MP so the he/she will put you on the treatment. There are materials to present to physicians on the study site and you can also order DVDs on the site to present to doctors that describe much of the science behind the treatment.

    If you doctor does agree to put you on the MP, make sure that he/she joins the “Private Section for Medical Professionals” which is the first forum on the study site. Once a member, he/she can communicate with other doctors/researchers involved with the MP as well as get direct guidance from Dr. Marshall when necessary.

    If your current doctor is not open to putting you on the treatment, then perhaps the advocates at http://www.curemyth1.org will be able to help you find a physician in your area who is.

    Good luck!

    Amy

  44. Jacob July 23rd, 2008 at 12:56 am 44

    I have a question? Why are there so many conflicting reports on Vitamin D3 levels? I was currently diagnosed with Bartonella spp. I am 28 years old and am getting better on the Zhang protocol. My doctor is one of the most respected doctors in the country. When I first had my tests ran for Vitamin D3…they were low. I have been supplementing and they have regained normality over the last 3 months. He stated that Vitamin D3 is a vital part of getting well and staying well. He claims that it helps hold microbes at bay. Also… I have read conflicting reports that microbes feed off Vitamin D3 and when levels drop, then you feel very bad, because Vitamin D3 acts as a hormone.

    So if the MP is correct and I live in AZ…how would I stay out of the sun and still be able to function somewhat normally.

    Does the MP believe in building the immune system back up? Zhang protocol sure does. I believe it is as vital as not feeding the microbes?

    Can a person eradicate these microbes from a person’s DNA using the MP?

    Thanks for your patience and time.

  45. Amy Proal July 25th, 2008 at 7:48 pm 45

    Hi Jacob,

    The main reason that conflicting reports on vitamin D are emerging is because we are living during a period in history where there is a great breach between what is known by molecular biologists about vitamin D and what is still taught in medical school about vitamin D (it’s outdated).

    Essentially, doctors – possibly Dr. Zhang – still visualize vitamin D largely as a vitamin when it reality molecular biologist know that it is a secosteroid transcriptional activator at the heart of innate immunity. If someone told you to supplement with a steroid would you think it was logical? Well, the vitamin D obtained from diet and supplements functions as a steroid. In order to understand how it temporary lowers inflammation and disease symptoms but makes them worse in the long run, I highly suggest you read the following article. Like other doctors, Dr. Zhang is probably mistaking immunosuppression for improvement:

    http://bacteriality.com/2007/09/15/vitamind/

    You may also want to take a look at Dr. Marshall’s recent paper on Vitamin D published in BioEssays:

    http://TrevorMarshall.com/BioEssays-Feb08-Marshall-Preprint.pdf

    Yes, the main goal of the Marshall Protocol (MP) is to strengthen the immune system. Patients take a medication (Benicar) that works by strengthening the innate immune response. I suggest that you watch the follow video, which is an overview of the MP, to learn about how the MP restores immune function in greater detail:

    http://bacteriality.com/2008/05/07/mpintro/

    We view Bartonella as a co-infection that generally takes hold because they immune system is not strong enough. So by restoring immune function with the MP, patients do (and have) recovered from Bartonella infections.

    Also, yes. When the MP kills the chronic intraphagocytic, metagemonic bacteria at the heart of inflammatory disease their DNA is eliminated along with them. So when a person has killed a certain bacterial form, its DNA is removed from the genome.

    Hope this helps!

    Amy

  46. saleh July 26th, 2008 at 2:40 am 46

    hi there
    my name is saleh, and I am disceasing in sarcodiose for 3 years or more I dont know but I dicover this discease after made X-rays to my heart as Doctor order. In Coincidence when doctors in hospital A.U.H saw a picture of X-rays she has a doubt in picuter and asked me to do another picture and advice me to make it in A.U.H its perfect and can read it.
    So she told me after made the picture to make Biopsy to know which family belongs this element show on picture.
    after made Biopsy she told me that I am Disease in sarcoidoise at that time I take cortizone with other drugs like metosikrate but when doctors said to me I will never can have baby until stop take this medical drugs I stop it but still go each 3 months to make test and interview with doctor there. last treatment and Picture they told me the disease stop and not exist but I still feel same Symptoms when Go up stairs or run
    I think what I wrote above give you a clear story about mine.
    So if you have any Idea to help me please dont hestiate to send me.
    b. regards
    saleh
    N.B: I poor and may be I dont have lot money to get treatment.

  47. Amy Proal July 26th, 2008 at 1:17 pm 47

    Hi Saleh,

    Thanks for writing. I’m so sorry to hear about your illness. You are right and your doctors are wrong. Unfortunately sarcoidosis never goes into remission so if you were diagnosed with the disease you still have it. This piece describes how sarcoidosis doesn’t go into remission in more detail:

    http://bacteriality.com/2008/02/23/misconceptions/#14

    Luckily there is a way for you to recover from your disease.

    Very recent research has made it clear that sarcoidosis is a bacterial illness. Your doctor is probably not aware of the related discoveries.

    Several types of bacteria cause sarcoidosis including bacteria that have adapted to live inside the cells of the immune system (where they cannot be attacked) and bacteria that live in protected colonies called biofilms. Read more about there bacteria here:

    http://bacteriality.com/2007/08/15/l-forms/

    http://bacteriality.com/2008/05/26/biofilm/

    This site describes a treatment that uses carefully chosen pulsed, low=dose antibiotics and a medication that activates the immune system (Benicar) to allow patients to gradually kill these bacteria. When patients have killed all the bacteria causing their sarcoidosis they become completely well again and do not need to take any palliative drugs or supplements. You can find interviews with several recovered patients on the right side bar of this site.

    The following article describes how the MP medications effectively target the chronic bacteria that cause sarcoidosis:

    http://bacteriality.com/2007/10/11/antibiotics/

    I also highly recommend that you watch the following video, which explains the Marshall Protocol and the science that forms its backbone in simple terms:

    http://bacteriality.com/2008/05/07/mpintro/

    Once you have read as much information about the Marshall Protocol on this site and the study site itself (www.marshallprotocol.com) if you have questions about the treatment ask them at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria). The patient advocates will answer you questions free of charge.

    I highly encourage you to use the Marshall Protocol to treat your disease as it is the only treatment to date that targets the root cause of sarcoidosis. Other treatment use steroids in an effort to “cover up” the problem. The steroids slow the immune response to the bacteria that cause sarcoidosis so that less are killed and the immune system’s immflammatory response to their deaths drop. However such a method offers only short-term palliative relief. In reality, because the immune system is weakened, the bacteria that cause sarcoidosis are able to spread with greater ease and make the patient sicker in the long run.

    The Marshall Protocol is not very expensive. You can order Benicar for about $50 a month from Canadian pharmacies. Because the antibiotics are taken in such low doses a little bit of antibiotic goes a long way. The antibiotics are not very expensive either.

    So I encourage you to look into the MP in greater detail!

    Best,

    Amy

  48. betty July 29th, 2008 at 5:03 pm 48

    Hi Amy,
    My daughter has been on the MP for three years as a result of Lyme disease and is in her final phase of treatment. She has been experiencing increasingly severe attacks of menstrual pain at the outset of her periods and the various anti-inflammatories that have been prescribed as well as taking magnesium have not helped. Her GP (who is not managing her MP) has advised her to begin birth control pills. Will they negatively affect or be negatively affected by the MP treatment? Apart from high doses of codeine is there any other treatment for the menstrual cramps?

  49. Amy Proal July 30th, 2008 at 5:49 pm 49

    Hi Betty,

    Last I checked, Dr. Marshall believes that the hormones in birth control pills do not reach high enough levels to interfere with immune function or any aspect of the MP.

    I’ve taken birth control for the past two years while on the MP. While I didn’t start it because of cramps, it made me cramp-free anyway!

    I started by taking Ortho-tri-cyclen-lo which did not work very well in my case and caused spotting. Then I switched to Nuvaring (a ring with hormones inserted into the vagina) and have been extremely happy with it.

    My period is light and short. I have no cramps. I don’t even have to take a daily pill. I have definitely made excellent progress on the MP over the past two years and don’t think Nuvaring has had any negative effects on my recovery.

    So I would encourage your daughter to try birth control in an attempt to alleviate her cramps, particularly Nuvaring.

    Best,

    Amy

  50. Feather Perry August 15th, 2008 at 5:41 pm 50

    How do I find a Dr. That can treat me?

  51. Amy Proal August 16th, 2008 at 9:55 am 51

    Hi Feather,

    Your first stop ought to be CureMyTh1 where a lot of your basic questions about the MP can be answered.

    Sometimes finding an MP doctor is difficult, but it’s certainly not impossible.

    Just so you know, with many doctors, you really have to make a case for yourself.

    I have two pieces of advice:

    1. Go to the members tab of the MP site and contact people on the MP in your area.. Find out who their doctors are and if they might be willing to take on a new patient.

    2. Figure out exactly what is holding your would be doctor back from prescribing this important therapy. Come to your doctor’s office prepared with at least the abstracts of studies which rebut many of the most common misconceptions. Read my piece Top 14 misconceptions about the MP.

    Good luck!

    Best,
    Amy

  52. sabuz August 30th, 2008 at 9:32 pm 52

    dear sir
    I am suffring with food sensitiviti and chemical
    sensitivity with choronic fatiuge syndrome.
    every time i am taking food it is making me weak,like
    sometime breathing trouble. thanks

  53. Amy Proal August 30th, 2008 at 10:00 pm 53

    Dear Sabuz,

    I am so sorry to hear about your poor health.

    I can’t give you medical advice. What I can tell you is that this site discusses a treatment, prescribed by doctors, for food sensitivities and CFS. The Marshall Protocol is a difficult treatment and you’d require several years to get well. Patients are seeing positive results. Try to read as much as you can about the MP. If you have questions about the treatment, please visit CureMyTh1.

    Best,
    Amy

  54. clare blandon September 3rd, 2008 at 11:31 am 54

    Can i get Marshall Protocol in Wales Great Britain as i have all the symptoms of CFS ?

  55. Rinog September 4th, 2008 at 2:58 pm 55

    I see on the expanded list of disorders that this protocol may help treat kidney stones. On what types of stones does the protocol work? What is the basic pathology involved in stone production?

    Thank you,

    Ringo Gato

  56. Amy Proal September 4th, 2008 at 3:14 pm 56

    Hi Ringo,

    Please forgive me for not responding to your comment earlier. For the last week and a half I have been in Portugal at the International Congress on Autoimmunity. I read your comment right before leaving and decided to wait with my response until I could ask Dr. Marshall and Dr. Grey Blaney (who were also at the Conference) about kidney stones in greater detail.

    In any case, Dr. Blaney told me that in his opinion, a kidney stone generally forms around a clump of L-form or nanobacteria – very small pathogenic bacteria that the immune system is unable to detect and kill.

    Once the L-form bacteria form a ball, it starts to become surrounded by calcium which hardens and begins to form the outer layers of the stone.

    The reason why extra calcium is produced and tends to accumulate around the stone is directly related to the dysregulated vitamin D metabolism that results when a person is infected with the Th1 pathogens that include L-form bacteria. Such pathogens are able to block the Vitamin D Receptor which subsequent prevents the transcription of enzymes that under normal conditions break the active vitamin D metabolite 1,25-D down into its inactive forms.

    The result is that 1,25-D rises without a feedback system to keep it in check. Since 1,25-D activates the VDR and the VDR transcribes genes that cause calcium production and generation, such genes get dysregulated and calcium end up in the wrong places. These places include kidney stones and calcium forms part of the plaque that contributes to cardiovascular disease.

    So the presence of kidney stones highly suggests that the person with the stones is suffering from infection with L-form bacteria and the Th1 pathogens.

    In such cases, the Marshall Protocol allows for correction of the problem. The low-dose antibiotics used by the protocol kill the L-form bacteria that cause the formation of kidney stones in the first place. Bacterial death also allows VDR metabolism to stablilize so that calcium production is once again correctly regulated.

    To my knowledge, the Marshall Protocol can help reverse and eliminate any kind of kidney stone. At least that’s what our the results of our phase II study are showing thus far….

    Best,
    Amy

  57. Lisa Logue September 12th, 2008 at 10:47 am 57

    Please help me find a physician to administer the MP to my husband. I cannot get through on the links you posted above. We are located in northcentral PA. My husband has been diagnosed with MS, Lymes Disease, and Mercury Toxicity and has problems with walking and balance. I truly believe the MP will help, I have long thought that all this was bacterial but getting a neurologist to think that, too, is impossible. Also, getting the Lyme specialist and other doctors to agree has also been a challenge. We approached our doctor at Hershey about the MP but he did not believe stimulating the immune system would work, we disagree. We are so frustrated. Another point of interest is that my husband comes from a large family of 10 children…at least 5 of them have neurological issues and autoimmune diagnoses. His Mom has Myesthenia Gravis, Vitelago, and has had issues with Calcium and Vit D–parathyroid related. Once again, I agree with the theory behind the MP and the role of Vit D and the reasons these issues can run in families….please, please refer me to someone willing to help us get started on the MP. You may even call me, at 570-435-5180. Lisa

  58. Amy Proal September 13th, 2008 at 7:52 am 58

    Hi Lisa and Clare,

    I’ll try to put you in contact with some MP doctors with patients in your area, although I can’t guarantee they are taking new patients. If that’s the case, it may be up to you to convince a doctor in your area on the MP. That may involve printing out materials from the MP study, providing your doctor with links to Marshall’s recent publications and possibly ordering the DVDs (which can be ordered by clicking on the top left corner of the website) to give to your doctor to help him/her understand the MP is the best treatment option for your husband.

    As I said, if your current doctor is not willing to put a patient on the MP, you should try to see if other doctors would be open to the possibility. I know this is difficult but this is worth it.

    Best,
    Amy

  59. Joe September 18th, 2008 at 2:22 pm 59

    Hi Amy,
    I presented my rheumy with a few of Dr. Marshall’s papers, and he dismissed them out of hand because of the lack of peer review from established medical journals. How can I argue against this? What does Dr. Marshall say about the peer review process?
    Thanks,
    Joe

  60. Amy Proal September 19th, 2008 at 10:55 am 60

    Hi Joe,

    That’s too bad your rheumatologist categorically dismissed the MP. On it’s face, it is simply untrue that Marshall doesn’t have peer-reviewed papers. The 2008 Bioessays is one. You could also point to the International Congress on Autoimmunity recently held in Porto, Portugal where Marshall *chaired* the session on vitamin D. This guy is certainly no slouch!

    I happen to have a lot of respect for physicians treating chronic diseases. They have to make a lot of tough calls, often using limited evidence. But, the problem I have is that their first-line treatments, many of which are immunosuppressive, have been shown to be ineffective. An expert’s opinion matters only as much as he/she has a track record of success, right?

    Look, I would trust an expert mechanic to fix my car with standard measures, because he has a track record for success. Even a cursory review of the literature will show that expert rheumatologists do not enjoy that track record.

    If your doctor wants more peer-reviewed papers supporting the MP, that’s fine. More will be coming out in the next year, but, Joe, your job isn’t necessarily to convince your doctor that this is a good option for you. It is to get well. See if you can find another MD. Visit CureMyTh1.org and request a list of doctors in your area.

    Best,
    Amy

  61. Chris September 19th, 2008 at 9:27 pm 61

    Amy,

    Welcome back from Portugal. Will we be seeing any video of Dr. Marshall from that event at some point on your blog – or elsewhere?

    Thanks,
    Chris

  62. Amy Proal September 19th, 2008 at 9:35 pm 62

    Hi Chris,

    Yes, I will be putting up footage of our talks at Porto and as well as a short description of the Conference in the next few days. Hopefully tomorrow or the day after…

    Amy

  63. Peter September 19th, 2008 at 10:10 pm 63

    Hello Amy,
    After testis cancer 13 years ago, I developed sarcoidosis. Doctors think it’s a consequence of radiotherapy and not bacterial. I went on prednison 6 years ago to treat sarcoidosis in lung and kidneys and after 5 years free of prednisone, my renal function is pretty bad again and I have also hypercalcimia and uveitis. Could MP work even if my sarcoidosis is a result of radiotherapy.
    Also I now live in Hong Kong and doctors don’t know much about sarcoidosis, let alone MP. How can I get started in the program?
    Thanks a lot.
    Peter

  64. Amy Proal September 20th, 2008 at 6:21 am 64

    Hi Peter,

    I’m not sure if there are any doctors in Hong Kong. I recommend requesting a list of doctors in your area from CureMyTh1.org. If there is no one even close, some doctors allow you to visit once and then communicate via phone calls and emails.

    You wonder if radiation therapy caused or exacerbated your sarcoidosis and, if so, if it’s a different, perhaps untreatable, form.

    Everything I have seen leads me to believe that the answer to that question is no.

    You may be surprised to know how many patients in the MP cohort have multiple symptoms just like you, and nearly all of them respond in the same fashion to the combination of vitamin D restriction, pulsed low-dose antibiotics and a VDR agonist like olmesartan.

    Radiation therapy is a profoundly immunological event, so it wouldn’t surprise me if indeed it played a role in your sarcoidosis.

    But, to some extent, it doesn’t matter. I would focus more on root causes. Consider this: is it any coincidence that you have four indications (uveitis, cancer, hypercalcemia, kidney dysfunction) at once?

    Best,
    Amy

  65. Peter September 20th, 2008 at 9:06 am 65

    Dear Amy,
    Thanks…I don’t know if I quite understand you. about the root causes.I had cancer 13 years ago and, a year later sarcoidosis. Now, after some time feeling well I’m experiencing uveitis and hypercalcemia as a consequence of SARCOIDOSIS, right? At least is what they tell me…
    I’m currently in hospital while they try to bring my levels of calcium in blood down and they tell me I’ll most probably will have to go on PREDNISOLONE again..(last time I took it for 12 months was 6 years ago)…So, in case I find a doctor open-minded enough to help me with the MP…does he have to have previous knowledge or he can learn as we go along?
    Also,supposing that the radiotherapy caused the sarcoidosis, then it wouldn’t be bacteria causing it, right? Shouldn’t that be treated differently? Could you please explain a bit more? Sorry to be so thick..I haven’t slept for 2 days and I’m a bit anxious about the whole thing…
    Thanks,
    Peter

  66. Amy Proal September 20th, 2008 at 9:23 am 66

    Hi Peter,

    Sorry, I should have been more clear. Our data and many other studies indicate that a wide range of inflammatory diseases are caused by different species of difficult to culture and stealthy bacteria – so the root cause is the same for each of these illnesses. These diseases include many forms of cancer, uveitis, hypercalcemia and sarcoidosis – all of which you have or have had.

    So what I’m saying is that these diseases are almost certainly connected. Some of the bacteria that caused your cancer may have survived treatment and over time mutated into other forms of bacteria that proceeded to infect your lungs and cause sarcoidoisis. It’s also very important to understand that these bacteria have methods by which they weaken the immune system as they proliferate. So once you accumulated enough bacteria to cause sarcoidosis it was probably very easy for other bacteria to infect your eyes and cause uveitis.

    But I know you are not sure if the sarc was caused by radiation or bacteria. My opinion, and the one that fits our data, is that the radiation might have greatly weakened your immune system. Many chemicals are known to do this and obviously it put your body under extra stress. So if the radiation made you weaker than usual, it would have been much easier for bacteria to infect your lungs and cause sarcoidosis. So while I think the radiation may have aided the development of your disease, I still think bacteria are the proximate cause and can be eliminated with the MP.

    Any doctor can administer the MP and the phase 1 guidelines are online. Also if you read a lot about the MP and how to do the treatment correctly, you can aid your doctor in understanding the treatment. So it may be in your best interest to present the MP to your current doctor or an open minded doctor in your area. I recommend showing them several of Dr. Marshall’s papers and recent presentations:

    http://www.trevormarshall.com/

    You can also order (for a very small charge) two DVDs about the MP that you could show to a doctor in order to educate him/her about the treatment. The DVDs can be purchased by clicking on the upper left hand corner of the MP study site – http://www.marshallprotocol.com.

    I also recommend posting about your situation at the following website:

    http://www.curemyt1.org (Th1 refers to diseases caused by bacteria, hence the name). The patient advocates on the site, who volunteer for the non-profit that runs the MP, should be able to present you with other materials on the MP to show to your doctor.

    Best,

    Amy

  67. Mark September 22nd, 2008 at 3:30 pm 67

    About 4 years ago I was prescribed a course of prednisone to dry my sinus cavity. the dose was to last a month. About a week into the medicine, my quadriceps became extremely weak and had a burning sensation. Also felt very stiff and needed constant stretching. I had never felt this sensation before and am generally very healthy in every other way. I have no other muscular symptoms. I fought this condition by regular and strenuous bicycling in an attempt to build up my leg muscles beyond what is required for a normal lifestyle. Also have recieved regular massage therapy. After about 2 1/2 years of this, I thought the condition was almost gone. Now it has returned. My doctor has been no help. After reading some of your materials, I am wondering if there is some bacterial connection here as a result of the immuno-suppression caused by the prednisone. What do you think?

  68. Amy Proal September 22nd, 2008 at 7:15 pm 68

    Hi Mark,

    I think you’re exactly right. The problem with your sinus cavity was probably related to chronic bacteria in your airway, especially since several recent studies have connected childhood bacterial infections to allergies, asthma, and sinus infections.

    I know your doctor probably had your best interests in mind, but he seems to fully appreciate how detrimental a drug prednisone is and how much being on the medication can increase a patient’s susceptibility to infections.

    I find it quite likely that your immune system, which has been stopped from being able to correctly fight the bacteria now increasingly implicated in musculoskeletal diseases, is the reason why you have accumulated such bacteria and are continuing to feel muscle symptoms.

    Don’t stress though. You can turn this around. The first step would be to wean off prednisone and find a more forward-thinking doctor.

    Then I would highly recommend that you do the Marshall Protocol to eliminate any bacteria that you picked up while on prednisone.

    Based on what you say, it doesn’t seem like your bacterial load is that high, so I would anticipate that your die-off reaction should be quite tolerable and that you could maintain a normal life even while on the treatment.

    The important thing is that you don’t allow these infections to spread any further.

    Before starting the MP, it helps to read as much as possible about the treatment — on this site and the study site. If you have questions about how to begin, find a doctor, etc., the best place to ask is at CureMyTh1.org where your questions will be answered free of charge by patient advocates.

    Best,
    Amy

  69. patti christel September 25th, 2008 at 12:34 pm 69

    Amy: My dad has pulmonary fibrosis. Will the MP help him?

  70. Amy Proal September 25th, 2008 at 1:53 pm 70

    Hi Patti,

    Yes. Pulmonary fibrosis is closely related to sarcoidosis, which the MP has a very strong success rate in treating. This thread on the MP site discusses pulmonary fibrosis and the MP in greater detail.

    After you read the thread and other info on the MP, if you have further questions about the MP, the best place to get them answered is at CureMyTh1.org where your questions will be answered free of charge by patient advocates.

    Good luck!
    Amy

  71. Sandra September 27th, 2008 at 10:04 am 71

    I have POTS (Postural Orthostatic Tachycardia Syndrome) with gastroparesis and GERD. Will the MP be able to help me? Have other patients with POTS had any success, I’ve had a look on the webpage and have been unable to find any confirmation.

  72. Amy Proal September 30th, 2008 at 8:45 pm 72

    Hi Sandra,

    Yes, I think there is great hope that POTS can be treated with the MP. I can tell you first-hand that the MP can improve POTS, because I had it.

    I’ve actually been involved in numerous projects, which keep me away from checking in on the MP cohort, but I think there are people with GERD on the MP, but I can’t be sure.

    The best place to ask about patients who might have your condition and are on the MP would be at the following website CureMyTh1.org (the Th1 refers to illnesses that are bacterial in nature). Patient advocates will respond to your questions free of charge and are much familiar with patients on the MP and their specific diagnoses than I am.

    POTS aside, even if there aren’t other patients with your diagnosis on the MP, I would still see it as your primary health option. The MP essentially treats diseases of unknown cause, which all seem to share a bacterial origin. It’s very likely that your diagnosis will fall in the same category.

    The way to know if the MP would work for your symptoms is to do a therapeutic probe. If you find you experience immunopathology, or a rise in symptoms after taking the MP antibiotics and Benicar, then the reaction means you’re killing bacteria, and that the MP will very likely work for you.

    Best,
    Amy

  73. Tom McNair October 2nd, 2008 at 8:12 am 73

    Hi Amy,

    What you are doing is an amazing service to people like me that felt there was no hope of curing their sarcoidosis. I want very badly to do the MP. I have written my doctor a letter (but haven’t sent it yet) asking if he would be willing to treat me. I registered for the site and got a doctors list of physicians that are currently treating patients with MP. When I tried to log on the next day, the site didn’t recognize my user name or password or e-mail address. When I tried to re-register, the site said it was full. I have read so much information over the past two weeks about the protocol and what resinated most with me was how important it is to post questions while doing the treatments to help regulate your medicine. Can I still do the MP? If so, how can I get started? Thank You and God Bless You!

  74. Amy Proal October 2nd, 2008 at 9:23 am 74

    Hi Tom,

    Thanks for the kind words.

    I’m not sure what you mean when you say that you have registered for the site. Do you mean CureMyTh1.org? Or, do you mean MarshallProtocol.com? The MP site is actually closed due to heavy demand.

    That shouldn’t overly distress you. There are lots of people doing the MP without posting on the MP site. The information is all there for you and your doctor.

    You say you want your doctor to put you on the MP, but that you’ve requested the doctors list. Any chance your doctor is on that list? If no, you have two options.

    One option is that you can try and convince your existing doctor. How you do it is up to you. I might read up on the MP. Take a look at my misconceptions article. You definitely could write a letter, but you could also explain, in person what the treatment is about:

    “There is this treatment, which involves pulsed-low dose antibiotics, the use of Olmesartan four times a day, and vitamin D avoidance. It seems to have worked out very well for other people sharing my condition. What would prevent you from putting me on it?”

    Option #2 is to see if some of the doctors on the physicians list would be willing to take you on as a new patient.

    I hope this helps. Good luck!

    Amy

  75. BJR (female - 37yrs) October 7th, 2008 at 2:22 am 75

    Hello Amy,

    Yes, You are doing something very special for all of us people… who are ill and looking for support. Your incredibly intelligent, thoughtful and thorough answers are noticed by all.

    I have been diagnosed with lupus, fibro, chronic fatigue etc., etc. I also am psychiatrically challenged with depression, anxiety, ocd and most likely bipolar. I have come to suspect that this is all related to some sort of bacterial infection…after much research only on my part and with no help from my doctors. Oh… and I have been sick for at least 15 years by the way. Can’t work, can’t get out of bed…

    My question is… I am wondering if I should be tested for Lyme disease…since I suspect Lyme for many reasons that I won’t bother getting into. Let’s just say that I REALLY fit the Lyme profile and criteria. Anyway…I don’t know if I should just skip Lyme testing and just find an MP doc and go that route, as it might be cheaper and the same treatment idea is used…essentially…or is it? Doesn’t the MP cover most bacterial issues, no matter what they are or where they came from? I think testing for Lyme might be a waste of time, since results can be false negative anyway. I also have to go far and out of the way for Lyme testing, as I live in Canada and docs don’t like to treat for Lyme here. What is your opinion?

    I will sign up on the site to find an MP doc if you think I should go that route. I am leaning in that direction…I think.

    Keep up the fantastic work and glad that you are feeling well.

    Sincerely,
    BJR

  76. Amy Proal October 9th, 2008 at 3:02 pm 76

    Hi BJR,

    Holey moley! You certainly have you fair share of diagnoses. It sounds like your day-to-day activities must be a real challenge, and for that my heart goes out to you.

    Should you try to get a Lyme diagnosis? I really doubt how helpful that would be. Most Lyme therapies including high-dose antibiotics are notoriously unsuccessful.

    The model of pathogenesis advanced by Dr. Marshall is that people with chronic diseases suffer from a Th1 Spectrum Disorder. The thinking is that you have a variety of latent forms of bacteria including l-forms and biofilms in different locations of your body. As you can see on this site, people with a wide range of symptoms – some with symptoms as varied and far-reaching as yours – have gotten back their lives on the Marshall Protocol.

    I warn you that it’s a long treatment especially for someone who is as sick as you appear to be.

    If I were in your shoes I would register at CureMyTh1.org and ask the free advocates there to help you find a doctor who prescribes the MP.

    Good luck!

    Best,
    Amy

  77. Barry Bonnett October 27th, 2008 at 1:08 pm 77

    Yes I have sarcordosis since 1998 I have been taking perdinone on and off for Ten years, the sarcordosis is on my spine, and also I have and scare on my spine from the sarcord, I walking ok but on my right side I only have 60-80%. Can you help me?

  78. Amy Proal November 2nd, 2008 at 8:23 pm 78

    Hi Barry,

    I’m very sorry to hear about your sarcoidosis and the scar that it has caused.

    Many of the articles on this website discuss a treatment called the Marshall Protocol (MP). The MP is free and is part of a Phase II clinical trial. Any patient with an inflammatory disease is welcome to participate. The MP does NOT use steroids to treat sarc because steroids slow the immune system from killing the chronic bacteria that are increasingly implicated in causing the disease. This makes patients worse which is probably why you are not getting better.

    The MP will allow you to kill these disease causing bacteria and potentially recover from sarcoidosis. However it is a very long and difficult treatment because patients must experience symptom flares that correlate with bacterial die-off.

    I recommend you watch the following video about the MP which describes the treatment and the science that forms its backbone:

    http://bacteriality.com/2008/05/07/mpintro/

    If, after watching the video you have questions about the MP, you should ask them at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria). Your questions will be answered free of charge by patient advocates.

    Good luck!

    Amy

  79. aso 47 year old female November 29th, 2008 at 3:03 am 79

    Hello, My husband has pulmonary fibrosis. Is the MP something he should look into to improve his health?
    Currently, his doctors are suggesting a lung transplant.

  80. Amy Proal November 30th, 2008 at 3:50 pm 80

    Hi Aso,

    Yes, the MP is definitely a treatment that you and your husband should investigate. There are subjects in the MP study cohort who are reporting gradual reversal of fibrosis – especially in the lungs.

    However the MP does not work overnight. It is a long treatment and patients must endure temporary flares in inflammation as the bacteria now known to cause fibrosis are slowly killed off.

    I don’t know if your husband’s lungs will be able to tolerate this bacterial die-off reaction if he is very ill. Nevertheless, at least trying the MP it is certainly worth a try before you resort to a lung transplant.

    The patient advocates at the following website are the best people to consult about your husband’s situation. They volunteer for the non-profit organization that runs the MP and answer questions free of charge:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria).

    Maybe they can also put you in touch with an MP doctor who could better access your husband’s ability to succeed on the MP.

    Best,

    Amy

  81. sally boutte December 1st, 2008 at 12:58 pm 81

    How do I go about finding a doctor who uses this method? Sally Boutte

  82. Amy Proal December 2nd, 2008 at 6:42 pm 82

    Hi Sally,

    The best way to find a doctor who work with MP patients is to write about your desire to find an MP doctor at the following website:

    http://www.curemyth1.org (Th1 refers to bacteria). The patient advocates on the site, who answer questions free of charge, should be able to provide you with a list of doctors who use the MP in your area.

    Good luck!

    Amy

  83. SHERMAN THOMAS December 2nd, 2008 at 7:53 pm 83

    HAVE HAD SARCOID FOR 20 YEARS.IT HAS INFECTED MY LUNGS. IM ON 5 LITERS OXYGEN MOST OF THE TIME.IM ON 20 MGS OF PRED.NOT MUCH RELIEF.I NEED HELP.

  84. Amy Proal December 6th, 2008 at 5:45 pm 84

    Hi Sherman,

    I’m very sorry that you have been suffering from sarcoidosis for so long. The research shows that scientists are increasingly implicating bacteria as the cause of sarcoidosis.

    You can kill the bacteria causing sarcoidosis with a treatment called the Marshall Protocol. However it is a very difficult treatment because you will have to deal with temporary increases in your disease symptoms as your bacteria die. Since you are already very ill, this reaction might be hard to tolerate.

    Still, I recommend learning as much about the treatment as possible. There is no charge for the treatment guidelines.

    The following video describes the treatment and the science that forms it’s backbone:

    http://bacteriality.com/2008/05/07/mpintro/

    This article describes how in works in greater detail:

    http://bacteriality.com/2007/10/11/antibiotics/

    If you have questions about how to get started, post them at the following website:

    http://www.curemyth1.org (Th1 refers to bacteria). The patient advocates on the site will answer them free of charge.

    Best,

    Amy

  85. mel December 8th, 2008 at 4:02 am 85

    Hello Amy

    Would just like to ask… my friend has chronic sarcoidosis. If he tried the Marshall Protocol, what exactly do you mean by sensitivity to light? Does it just affect the eyes? or does it mean that if he’s exposed to light it will affect his treatment and ability to get well? Please elaborate.

    The sarcoids have started to affect the finger bones, so we are very worried. His doctor thought it had plateued and discharged him , but recently we found out it had come back and is now diagnosed as chronic.

    Please advise regarding the light sensitivity.

    Regards, mel

  86. Amy Proal December 10th, 2008 at 4:34 pm 86

    Hi Mel,

    I’m glad you are looking into the MP for your friend.

    The following article discusses light sensitivity and the MP in greater depth:

    http://bacteriality.com/2008/02/23/misconceptions/#8

    To recap some of what the article describes, the vitamin D system (which controls the innate immune response) is dysregulated in chronic disease. Those patients who have higher bacteria loads have a greater degree of vitamin D dysreguation and thus become more light sensitive. But as bacteria are killed over the course of MP, light sensitivity gradually resolves.

    So the degree to which your friend will become sensitive to light is basically tied to how sick he is. If his bacterial load is very high he will likely have to block sunlight when outside by wearing long sleeves, a hat, etc. He will also have to wear dark glasses outside and maybe even inside in stores or places with bright lighting (flourescent).

    Blocking light is burdensome but most MP patients accept it as necessary because it allows them to succeed on the MP and get their health back.

    If your friend doesn’t avoid light will it affect his progress? First, it depends on how light sensitive he will become – something I cannot predict.

    But if he is light sensitive, then getting extra light will cause the active form of vitamin D to rise to a point where it will start to dysregulate several of the receptors that control hormone function. That will cause him him experience extra uncomfortable, unneeded symptoms. Since he will already be dealing with a die-off reaction by killing the bacteria making him ill, if he has to deal with light generated symptoms as well, he will probably not be able to proceed through the treatment at good rate. So yes, getting too much light could affect his progress, albeit more at the beginning of the treatment when bacterial load is at its highest.

    Hope this helps,

    Amy

  87. Damian Scott January 8th, 2009 at 5:50 am 87

    Hi, I was diagnosed with Sarcoidosis in July 2008 after experiencing extreme joint pain/stiffness, migraines, chest pains, wheezing and a persistant cough.

    Initially my doctor injected depo-medrone which got me mobile again. Also, I was prescribed Naproxen (prior to the depo) but the visual migraines lingered on. It was only after reading about the MP that I suggested to my doctor that we might try Minocycline. My visual migraine abaited within 4 days, as did the wheezing and coughing. I’ve also amended my diet (since the new year) and have cut red meat and alcohol. Again, I have noticed a BIG improvement in my general welbeing. However, my antibiotics have now run out and my doctor will not prescribe any more (my specialist sent her a letter stating that antibiotics are not recognised treatment for sarcoidosis).

    I’m a tad concerned that my cough, wheezing and visual migraines may return, undoing the progress that we have made in the past 6-or-so months.

    Any advice would be gratefully received.

    Thanks,

    Damian

  88. Amy Proal January 8th, 2009 at 5:38 pm 88

    Hi Damian,

    Yes, unfortunately you should be concerned about the state of your health as data on sarcoidosis shows your symptoms will almost certainly return. Contrary to what some doctors say, sarcoidosis does not go away on its own. This article describes the largest study on sarcoidosis to date and how its results back the fact that the disease will persist if left untreated:

    “If I don’t do the MP, my illness might go away on its own”

    http://bacteriality.com/2008/02/23/misconceptions/#14

    It’s extremely important that you treat your sarcoidosis correctly. Although taking minocycline was a step in the right direction, were you taking it at the doses specified by the MP Phase 1 guidelines? Were you taking it along with Benicar? The reason I ask is that if the MP is working correctly, then patients actually feel temporary rises in their disease symptoms (called immunopathology) after each dose of antibiotics. This is due to the fact that when the bacteria that cause sarcoidosis die, they release toxins and cellular debri into the surrounding environment. As the body deals with these products symptoms flare, but the end result is that you are killing the bacteria making you sick which leads to real recovery and not just palliation of disease symptoms.

    If your doctor won’t give you minocycline or better yet put you on the full MP, then you need to find a new doctor. Your health is too important to work with a doctor who is not willing to take a look at the most recent research on sarcoidosis.

    I recommend posting about your situation at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria). The patient advocates on the site, who work for free, can provide you with a list of doctors who have MP patients in your area. You could hopefully work with one of these doctors to ensure that you do the treatment correctly and recover your health in the same way that so many others with sarcoidosis are doing thanks to the MP.

    In the meantime I highly recommend watching this video which provides an overview of the MP and the science that forms its backbone in simple terms. It should help you better understand what to expect from the treatment and exactly how the medicines work:

    http://bacteriality.com/2008/05/07/mpintro/

    I really hope you take action and pursue the MP…good luck!

    Amy

  89. Brent January 8th, 2009 at 10:12 pm 89

    Hello Ms. Proal,

    My wife has extreme sarcoidosis. She is losing her sight in her one good eye, (2 surgeries in the other) her joints hurt, etc…. I have read a little about the bactiria thing, but this site really explains it. Please e-mail me if there is anything you could do to help or is she could be someone you could learn from. She is only 23 and seems to have had symtoms for her whole life and it is now very bad.
    She has tried all the normal meds for sarcoid. Methotrxate caused a bad reaction in the liver. Now they want her to try Orencia. I want her to be healed! She has been on prednisone for 5 years or more and we know thats not good. Let me know if you can help. I will read about MP and see what we can do.

    Thank you

  90. Amy Proal January 10th, 2009 at 11:26 am 90

    Hi Brent,

    I’m very glad you found this site. I’m so sorry to hear about how sick your wife is. Unfortunately, we are living at a time when most mainstream physicians are unaware of the true cause of sarcoidosis and, as in your wife’s case, administer medications that only make their patients worse.

    The latest molecular research on sarcoidosis has made it clear that it is a disease caused by chronic bacteria that infect the lungs, joints, eyes, and nearly every tissue of the body. You can read more about these bacteria here:

    http://bacteriality.com/2007/08/15/l-forms/

    http://bacteriality.com/2008/05/26/biofilm/

    These bacteria can be gradually killed using a novel treatment called the Marshall Protocol (MP), allowing your wife to gradually recover. Hundreds of patients in the MP clinical trial are reporting improvement and recovery from sarcoidosis. Your wife can be among them, especially if she starts the treatment as soon as possible in order to stop her bacterial load from spreading.

    The Marshall Protocol is run by the California non-profit organization Autoimmunity Research Foundation. This article describes the treatment in greater depth:

    http://bacteriality.com/2007/10/11/antibiotics/

    I also highly recommend you watch this video which describes the treatment and the science that forms its backbone:

    http://bacteriality.com/2008/05/07/mpintro/

    More information about the treatment is available on the Marshall Protocol study site itself – http://www.marshallprotocol.com

    Once you better understand the MP, you should look for a doctor who will prescribe your wife the necessary medications to do it. You can request a list of doctors that work with MP patients in your area at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria). The patient advocates on the site will also answer any other questions your might have about the Marshall Protocol free of charge.

    You may want to convince your wife’s current doctor to put her on the MP. If so, here is a list of Dr. Marshall’s peer reviewed papers and presentations which he/she will likely want to see:

    http://mpkb.org/doku.php#publications_presentations

    Here is a packet of information about the Marshall Protocol (MP) to present to a doctor:

    http://www.marshallprotocol.com/forum2/11458.html

    Here are the MP phase 1 guidelines:

    http://www.marshallprotocol.com/forum2/2275.html

    I hope that you pursue this treatment option. I got deathly ill with CFS when I was 21. CFS is also caused by bacteria and very similar to sarcoidosis. I got sicker and sicker on “standard” treatments for the disease. Then I found the MP and today I have my life back. Your wife is young, and although the MP is a long treatment to complete, in a few years there is great hope that she can become completely healthy again. The steroids your current doctor is using are actually shutting down her immune system – reducing the pain of bacterial death but actually allowing her bacteria to spread.

    Best,

    Amy

  91. Louise Whelan January 20th, 2009 at 1:33 am 91

    Hi Amy,
    Thankyou so very much for your site. I have been going through the maze of specialists for the past year in an attempt to find a diagnosis & treatment for my litany of “vague” symptoms. I had an implanted spinal opiate pump, which delivers morphine intrathecally, almost 3 years ago to treat chronic pain, the result of a workplace accident over a decade ago . I realisenow that I had many symptoms prior to the development of severe cognitive problems almost 9 months ago , atypical pneumonia, frequent episodes of bronchitis & tonsillitis ,erratic mood changes, sweats, weight gain & loss & also amenorrhoea for approx 4 yrs. However , there was always some other reason to put these symptoms down to a stressful job & other lifestyle stresses. When the cognitive problems arose I began to really worry ,I am a healthcare professional & was concerned about how this would impact my ability to practice, I still am. It was discovered I had low cortisol & oestrogen – I was put on fludrocortisone – despite not having a mineralcorticoid deficiency – I initally fell much improved. After seeing an endocrinologist, who put me on cortisone acetate – things fell apart altogether.I had such debilitating fatigue I could barely function & was hospitalised for 3 weeks. I have seen my endo again today – he doesn’t believe my low hormone levels are a significant contributing factor to my fatigue & other symptoms -poor memory , weight gain, frequent infections, dizziness etc. It is thought by my pain specialist & apparently now widely accepted, that spinal opiates over the longterm cause hypothalamic & pituitary dysfunction, however my CRP & ESR remain elevated with a mild leucocytosis that comes & goes. Rheumatoid factor is negative & ANA titres borderline. Personally , when I review the history of all my symptoms it seems consistant with CFS, which after all is only diagnosed when everything else has been eliminated. I find it so frustrating how medicos ,especially specialists treat within their own narrow sphere of so called expertise & refer you to others to deal with other systems, as I seem to be broken down into systems , not treated as an entire being , all of my symptoms are inter related. It’s also frustrating that they frequently don’t communicate with each other. My General Practitioner ‘s philosophy is to do nothing in case you actually might uncover something, that’s all very well but when I have become so dysfunctional – my post grad study is on indefinite hold , I have had to stop working in research & can barely cope with working 3 days per week in general practice, I have practically no social life at all , so doing nothing is, for me , not an option. Can you put me in the direction of finding a doctor in Australia who is open to the MP ?
    Louise Whelan , Melbourne, Australia

  92. Amy Proal January 20th, 2009 at 12:01 pm 92

    Hi Louise,

    I’m sorry to hear about the development of your disease and how your doctors essentially do nothing to treat its underlying cause. I know what you’re going though since I also saw a tremendous number of doctors to no avail when I was developing CFS. When I finally found the MP everything changed. Today I live a normal life again. You can get there too and I’m glad you are looking for a doctor who can administer the MP.

    I recommend that you post about your desire to find an MP doctor at the following website:

    http://www.curemyth1.org (Th1 refers to disease caused by bacteria, hence the name.) The patient advocates at the site, who are volunteers, will provide you with a list of doctors who administer the MP in Australia. Perhaps they can also put you in contact with other Australian MP patients.

    Good luck!

    Amy

  93. Andrea Asch January 31st, 2009 at 6:38 pm 93

    I am about to start the MP. I have scleroderma (2 yrs), reynauds and recently diagnosed with Lyme. I have not read anything about successful MP treatment for people with scleroderma, not common. I have no organ impact, just inflammation of the tendon, muscles not joint impact. Will the MP help me? I have a local doc who will follow me, which is great, however I undestand that most of my support will come through the web site, is that enough? I am getting a bit worried, perhaps overwhelmed. The lifestyle changes are significant, but so is the need to get back my active life. I want to understand the foods to aviod, better. I am a full time working Mom with an active family, yikes am I ready for this?
    Andrea

  94. Amy Proal February 1st, 2009 at 1:59 pm 94

    Hi Andrea,

    I know the MP can seem overwhelming at the outset. The good news is that you’ll know whether the treatment is working as soon as you start the medications. If you feel flares in your disease symptoms after taking your MP antibiotics along with Benicar then you are experiencing immunopathology. The reaction is proof positive that you are killing the bacteria making you ill.

    Luckily, you can dose the MP antibiotics at a rate that is right for you. Since you are a busy woman, you can dose them at a slower rate so that your immunopathology will not be as strong. Ramp your antibiotics carefully so that you never experience immunopathology that slows you down too much.

    Still, I anticipate that you will feel somewhat worse on the MP than you do now. You may have to decrease you activity level, at least during the first stages of the treatment. But this is a “pain with gain” situation. As you proceed to kill bacteria over the course of the MP, things definitely get easier.

    In terms of support, do you post your concerns regularly at http://www.curemyth1.org? Th1 refers to diseases caused by bacteria, hence the name. The patient advocates on the site can give you advice and guidance about MP-related issues.

    You may also want to look on the MP website for other patients with scleroderma or reynauds and send them an email or private message. You can ask them about their experience with the MP thus far and for any guiding advice.

    The following webpage give a through overview of foods that contain vitamin D which should be avoided:

    Also, these article describes the foods to avoid while on the MP and why:

    http://mpkb.org/doku.php/home:food:home

    http://bacteriality.com/2007/10/02/diet/

    I think that you will be less nervous about the MP once you have actually started the medications and note how you react. Then you will be able to judge your energy levels etc and not have to speculate about them. The moderators on curemyth1,org are there to guide you as you begin the treatment so take advantage of their presence. I think you are ready for the MP – you are definitely ready to start the process of getting your health back.

    Best,

    Amy

  95. Melinda Jonas February 16th, 2009 at 10:41 am 95

    I have an undiagnosed stomach condition and my tendency to overgrow yeast in my system and my low Vitamin D levels are consistent with the inflammatory problems that the Marshall protocol is designed to correct. Does my condition sound like it can be helped by the Marshall Protocol and if you know the success rate of cases like mine (if it can be helped)?

    Also, I am extremely sensitive to medicines and try to avoid taking them if possible. It’s hard to imagine taking so much Benicar when my blood pressure is already so low (around 90-100 top number; between 50-60 bottom). Any thoughts on this?

    Thank you for your time.

  96. Amy Proal February 17th, 2009 at 8:37 pm 96

    Hi Melinda,

    I do think the MP is worth trying. Try a therapeutic probe and see if you get the telltale immunopathological reaction. If you do, then you know that the MP can work for you.

    I can appreciate that you are sensitive to medicines, that your blood pressure is already low, and that you are wary of using Benicar. Unfortunately, there is no MP without regular doses of Benicar. If you want to activate your innate immune response and kill the pathogens responsible for disease, you must activate the Vitamin D Receptor. Read more here.

    Low blood pressure should not be a reason not to do the MP. When I started the MP, I had radically low blood pressure. In fact, one of my doctors told my I had the lowest blood pressure he had ever seen in a CFS patient. Benicar appears to work in chronically ill patients than healthy people and those of us who use for immune-stimulating properties should generally see very little drop in blood pressure upon using it. However, low blood pressure will return as part of your immunopathology. Read more here.

    Best,
    Amy

  97. Anthony Murawski February 19th, 2009 at 7:32 pm 97

    Hi Amy,

    I was diagnosed nine months ago with late stage Lyme disease. It’s obvious now that I’ve had it for 28 years. I’m being treated by two LLMDs.

    I’m curious to know what kind of progress is being made by Lyme patients on the MP. I’m wondering whether they are actually getting well, without relapsing, or whether they are experiencing an improvement in symptoms only while on the MP. If it’s the latter, I can think of one obvious explanation. A high percentage of people with chronic Lyme have cerebral hypoperfusion due to brain inflammation. Since Benicar is a vasodilator, it should produce a reduction in symtoms by increasing cerebral blood flow – which does not necessarily indicate progress in treatment. I’m curious whether supporters of the MP have taken this into account.

    Sincerely,
    Anthony Murawski

  98. Anthony Murawski February 22nd, 2009 at 1:05 am 98

    Hi Amy,

    Just another thought on this…

    There may be an easy way determine whether vasodilation with Benicar is the real reason why Lyme disease patients are experiencing symptom reduction on the MP. Since Borrelia burgdorferi is a slow-growing organism, and if the common coinfecting organisms (Mycoplasma, Bartonella, Babesia, etc.) are also slow-growing, Lyme patients on the MP should not experience any increase in symptoms if they stop taking Benicar for a few weeks. If they did this, but stuck to the rest of the protocol, a resurgence in symptoms within two or three weeks would indicate that cerebral vasodilation is the real reason for their symptom reduction on the MP. Sticking to the rest of the protocol would factor out increased vitamin D intake as a potential cause of symptom resurgence.

    What do you think?

    Sincerely,
    Anthony M.

  99. Amy Proal February 22nd, 2009 at 10:31 am 99

    Hi Anthony,

    I can’t say I agree. Your explanation accounts for why patients with one disease experience positive improvements on the MP, but what about the dozens of other diseases? How does your theory account for them? There is some pretty good science supporting why olmesartan makes patients feel better, which you can read about here. From this perspective, the science says that olmesartan makes people feel better because it’s a potent anti-inflammatory.

    By the way, there are at least three Lyme patients on Bacteriality who have gotten “much better.” You can also find patients on the MP study site itself.

    Best,
    Amy

  100. Anthony Murawski February 22nd, 2009 at 2:53 pm 100

    Thanks, Amy.

    If Benicar makes people feel better because it’s a potent anti-inflammatory, that pretty much amounts to the same thing, i.e., symptom reduction, but not necessarily progress in disease treatment. Yet Benicar is a potent vasodilator, so I’m surprised you’d dismiss this theory out-of-hand.

    As for vasodilation, I’m only talking about Lyme disease here. I have no idea whether my theory would apply to other diseases. I did hear recently from another Lyme patient that cerebral hypoperfusion is common in CFIDS, though I haven’t looked into it. It seems to me that any inflammatory disease that affects the brain might cause cerebral hypoperfusion.

    In the case of Lyme — if the coinfections are slow-growing, like Borrelia burgdorferi, my theory would be very easy to validate or invalidate in just a few weeks, with little or no risk of affecting overall treatment progress. If Lyme patients on the MP stopped taking Benicar for two or three weeks, and stuck to the rest of the protocol, a resurgence of symptoms could not be attributed to increased vitamin D intake, or to growth of the infections. That would make it pretty obvious that the real benefit is vasodilation from Benicar. In my book, clinical experience always trumps beautiful theories. In the case of Lyme disease, I get the impression that clinical experience with the MP shows symptom reduction – but I’m not aware of anyone on the MP actually being cured of Lyme disease and remaining symptom-free after discontinuing the MP. I’m not saying this will not happen, but it could take additional years for these patients to find out. You might spare them a lot of lost time and sacrifice (such as cutting out sunlight) by validating or invalidating my theory in just a couple of weeks.

    For now, I’m trying high-dose IV antibiotics to target all three forms of B.b., plus an agent like lumbrokinase to break down biofilms. This approach has a very strong track record – tens of thousands of people with advanced Lyme disease have actually been cured this way. It seems crazy to me to try an unproven experimental approach like the MP, when the cure rate with high dose antibiotics for chronic Lyme is eighty percent.

    I sincerely hope my theory is wrong. I’d be thrilled if the MP worked. But I wouldn’t try it until I saw some strong clinical evidence that a high percentage of people are actually being cured of Lyme disease on the MP, rather than the current clinical evidence, i.e., 60% of Lyme patients on the MP experiencing a reduction in symptoms (29 out of 51 Lyme patients experiencing reduction in symptoms, according to J.C. Waterhouse in the April 2007 issue of the Townsend Letter).

    Sincerely,
    Anthony M.

  101. Amy Proal February 22nd, 2009 at 3:02 pm 101

    Anthony,

    80%? I wonder where you’re getting your cure rate from and for how long it is claimed. Most of the studies I’ve seen are for only a couple months. Even a couple years is not nearly long enough, IMHO.

    I think you might benefit from considering why high doses of antibiotics contribute to short-term relief. At that dosage, these drugs are immunosuppressive. You’ll feel good for a while and then you’ll crash.

    Thank you for your explanation about vasodilation. Sorry, I still disagree. I just don’t think it’s supported by the science.

    The Townsend Letter refers to study data that was collected on patients in the middle of treatment. There were no controls. The methodology wasn’t amazing. If definitive clinical evidence from controlled studies is what you require, you’ll get that, hopefully in a several years time. Of course, you won’t get any better in the meantime. Your choice.

    Best,
    Amy

  102. mo February 26th, 2009 at 5:51 am 102

    Dear Ami,
    I have been trying to find out about any data/studies on patients, even small studies, that can give me an idea of how effective the MP protocol actually is. The theory is fascinating but are there any stats on how effective it is?
    I would be grateful for any such information.
    I was recently diagnosed with Lyme and at present am quite confused from reading of so many different approaches to “treatment”.
    Thanks
    Mo

  103. Amy Proal February 27th, 2009 at 10:04 am 103

    Hi Mo,

    There will probably be a couple controlled studies in the works, but if you want the best data we’ve come up with so far, you can look at the results from 2008 survey, which was presented by Tom Perez at the Congress on Autoimmunity in Porto, Portugal.

    Hope this helps.

    Amy

  104. Melinda Jonas March 8th, 2009 at 10:35 pm 104

    Hi Amy,

    I have written to you already asking about the MP. I have consulted with a doctor about starting. He ordered serum tests and suggested that I run the results by you: my vitamin D level: 13; 25-hydroxyvitamin D: 38. He has informed me that in his opinion, with results like these, I would benefit from the MP. In the past, I have tried to supplement vitamin D, but I get sicker. My body has reacted in negative ways (allergic reactions, GI symptoms worsening) with any other “treatments” I’ve attempted to aid my condition. Perhaps he feels that with your opinion, I can make a better informed decision about the MP being what I try next.

    Thanks for your time.

    Melinda

  105. Karen Collier March 9th, 2009 at 9:30 am 105

    How do we find a doctor who knows about this procedure? We live in Idaho. My daughter has fibromyalgia and it seems to be getting worse lately. We are deperate for some help and relief for her.
    Karen Collier

  106. Chris Caston March 9th, 2009 at 10:45 am 106

    Hi Amy,

    I’m really loving your website and your articles. I think you are a very intelligent and attractive woman.

    I would like to ask about the MP and how it might pertain to people that actually don’t have any major diseases but would still like to kill and stop the spread of as much harmful bacteria as possible in order to slow the aging process.

    Is there a guide for healthy people?

  107. Amy Proal March 9th, 2009 at 4:51 pm 107

    Hi Karen,

    I’m so sorry to hear about your daughter’s condition but I truly think she can recover with the MP. The treatment certainly allowed me to recover from a terrible case of fibromyalgia. I don’t have a list of doctors that administer the MP. However, you can request a list of doctors in Idaho with MP patients at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria, hence the name). The patient advocates on the site, who are volunteers, will provide it to you free of charge.

    If it turns out that no doctors in Idaho are taking new MP patients then you may want to try to convince you current doctor or an open-minded doctor in your area to put your daughter on the treatment. Here is a list of peer-reviewed papers and publications by Dr. Marshall and team that should put them much more at ease about putting her on a new therapy:

    http://mpkb.org/doku.php/home#publications_presentations

    Also, I know there are quite a few MP doctors in Washington State if you can’t find one in Idaho. I’m not sure how close you live to Washington State, but that could be another option and you could ask for the doctor’s list there as well on curemyth1.org

    I really hope your daughter can find a doctor and start the MP. I remember when I was younger and my parents were worried sick about my fibromyalgia and CFS. We tried possibly every treatment out there for the condition with no success before finding the MP. Then the treatment gradually turned my life around. Now I live with my boyfriend in New York City. I go out with friends all the time, work, and will be starting graduate school this coming fall. I am so grateful for my recovery. I hope the same thing can happen to your daughter.

    Best,

    Amy

  108. Amy Proal March 9th, 2009 at 5:12 pm 108

    Hi Chris,

    Glad you like the site! It’s great to hear from people who want to start the MP as a preventative. It makes so much sense to kill any bacteria you might harbor before they grow into larger colonies or forms that are more difficult to kill. And you may have read in my article about aging and the MP, there is a great chance that the aches and pains of aging are caused by many of the same or similar bacteria involved in other diseases that manifest at an earlier age.

    There is not a special protocol for healthy people who want to do the MP. Still, there are healthy people on the treatment. What they do is simply follow the same regular MP guidelines except often with a bit more flexibility. For example, sick people on the MP should definitely strive to take Benicar four times a day. But people who are not very ill can generally afford to take it only three times a day and get the same results. The antibiotics will probably be very easy for you to ramp as you die-off should be quite mild. You will probably reach the max dose fairly soon. Then I would just recommend staying on that dose for as long as you want to, switching up antibiotic combinations every so often to see if you can get at different kinds of bacteria.

    If for some reason you find that you do experience very notable bacterial-die off (immunopathology) then you can slow the abx down. In your situation, you are really not in a rush. You can stretch out and lower the antibiotics to wear down your bacterial load very gradually. In this way you should be able to pretty much keep up the same level of activity you had pre-MP. Also since light sensitivity is based on bacterial load, I wouldn’t anticipate too many problems with light. Also, the MP meds have so few, if any, side effects that I don’t think you would be harmed at all by taking the meds. In fact, Benicar is increasingly shown to help decrease arterial plaque, reduce kidney inflammation etc, and you can reap these positive effects too.

    My twin sister is currently using the MP as a preventative. She takes Benicar 3X a day and minocycline and clindamycin (as per the MP guidelines) every other day. Since starting the treatment she says she feels more tired sometimes. Occasionally she has some acid reflux symptoms which isn’t surprising since she had acid reflux issue before the MP. If she spends a long day in the hot sun she feels more worn out than she would pre-MP. She does not sunbathe, although she still get quite a bit of sun. Oh- also she avoids vitamin D in foods but sometimes eats it as long as it comes from a natural source.

    Overall, she still parties a huge amount, works full time and the immunopathology from the MP is there but seems like something very easy to push through. I cannot say that is exactly what would happen to you, but it would certainly be interesting to try! I bet you’d be giving yourself a giant pat on the back a decade or so down the road when you see other people increasingly complaining about aches and you really don’t have too many.

    Just to be on the side of caution be careful about getting too much light until you figure out what you can tolerate.

    Otherwise I say go for it and I wish more people considered doing the MP in a preventative manner!

    Best,

    PS I guess the hardest part would be finding a doctor who would prescribe meds to a healthy person. I hope you doctor is open-minded!

    Amy

  109. Dana March 12th, 2009 at 7:59 pm 109

    Hi Amy,
    I see Dr. Mercola is going to present an article; “I am posing a long comprehensive article in two days, Saturday March 14th which completely debunks the Marshall Protocol.”
    http://articles.mercola.com/sites/articles/archive/2009/03/12/Vitamin-D–The-Master-Key-to-Optimal-Health.aspx
    I see the vitamin D as another scam along with the Omega 3 claims. They both appear to work by suppressing the immune system.

  110. Amy Proal March 16th, 2009 at 2:29 pm 110

    Hi Dana,

    You are absolutely right – vitamin D and omega 3′s from fish work like steroids to slow the immune response. They are extremely harmful for people who are trying to deal with any sort of infection, including those chronic infections that are now thought to cause a wide array of inflammatory diseases.

    Now I’ve had the “pleasure” of reading Dr. Mercola’s article. I wrote two comments in response to the piece, although for the most part, since the article is so hopeless, I’m just going to let it be as my energy is better used elsewhere.

    Dr. Mercola openly admits that he “learned everything” he needed to know about the MP at a conference years ago. And he actually wrote me back saying he has never felt the need to read anything associated with the science behind the treatment since he immediately dismissed it based on what is clearly misinformation about his understanding of how MP patients can deal with light.

    He quotes a researcher (Dr. London) during the piece who is actually not a researcher, but an IT worker at MIT. It turns out Mr. London started the MP several years ago but was banned from the treatment because of his Lyme rage towards the volunteers and other patients. His interpretation of the MP is TOTALLY off and is laced with anger at the treatment. Yes, a very impartial source, I know.

    The other researcher he quotes is the head of an organization called the vitamin D council that zealously promotes vitamin D supplementation. Marshall’s work is a mega threat to this guy, since if Marshall is right, this guy is out of a job….and will also lose any prestige or medical tenure.

    In fact, how could Dr. Mercola possibly claim to write a fair piece on the MP when he makes money selling vitamin D and tanning beds? Are we really supposed to think he will embrace or even pause to listen about a treatment that will sink his entire website and career?

    Long story short, the article strings together misconception after misconception. I hope people who actually look at the MP science will realize right off the bat that his claims don’t make any sense. Unfortunately, there will be those readers whom he will just confuse and prevent from possibly recovering their health. It’s a huge shame.

    Best,

    Amy

  111. wm hart March 18th, 2009 at 5:44 pm 111

    Hi,
    Ref: Understanding L-form Bacteria

    You suggest that L-forms have no flagella and yet Borrelia burgdorferi (Bb) other forms are reported to have same.
    Have been reading on Bb for a number of years and trying to connect with Laminitis (Barbaro) (among other human diseases).
    Because Bb has so many other variants it seemed as though the L-form was a minor player. But after your article it appears that nothing is minor about Bb.
    Does the L-form effect the endothelium and play arole in endothelial dysfunction?
    Does it effect the Ca2+ channels of transport?
    Does temperature, pH and or cell density alter this form?
    Does the L-form have specific OSP designation? Specific band in the Western Blot if recognized?
    Best wishes for continued good Health.
    b06@comcast.net

  112. Furch March 19th, 2009 at 3:42 am 112

    I’m real glad the mercola-article wasnt the first one I read about the mp, if so It would be hell of a lot “easier” to go along with – given the complexity about the science behind the mp. And mercola has the benefit of the hyped up vitamin D.

    Luckily I’ve been doing extensive reading for months now, and theres no doubt im my mind about the mp science

    - It was my gradual decline in health from vitamin-D supplementation that lead me to this site in the first-place – and it was hard to swallow that it might not be the miracle-vitamin they say it is – It surely isnt – but for reasons that cannot be explained in a few sentences, like mercola obviously thinks..

    Quite a coincidence that this article came just when a lot of mp-papers have gotten published, and nearing towards a larger professional acceptance.. You’d think mercola read this and got a panic-attack? Why cant he look seriously at stuff? and join the common cause of healing the sick instead of sticking to the same dogma he claims to oppose!? Tragic – but he’ll have to come to terms with this sooner or later!:)

    Tnx Amy for youre wonderful site:)

  113. Amy Proal March 19th, 2009 at 2:33 pm 113

    Hi wm,

    Although I write about L-form bacteria based on what I read in the published literature, I am don’t have answers to many of your questions. I can say that the L-form is a specific phase in the life cycle of a bacterium. While a pathogen like Borellia might have flagella at one point during its life cycle, it may lose the flagella when it turns into a more latent persistent pathogen.

    I know that in the lab, L-form bacteria will only grow at very specific temperatures and under very specific pH levels. This may suggest that in the body, they need certain temperature/pH conditions to thrive, but I don’t know for sure and I don’t have a paper to back up that assumption.

    I’m not sure that the L-form can be detected on western blot. What I mean is that a pathogen that has an L-form can be detected by Western Blot but I don’t think the test is able to distinguish what form the bacterium is in at the time it is sampled.

    In order to get better answers to your questions I suggest you try to contact an L-form expert. I interview Nadya Markova on this site who is extremely knowledgeable about the L-form. Here is the interview which mentions her website. I believe it has contact information:

    http://bacteriality.com/2007/09/09/markova-interview/

    You could also buy a copy of Lida Mattman’s textbook on L-form bacteria and dig through it yourself in order to look for answers to your specific questions. It has fascinating pictures. I believe you can buy it off Amazon, just search for “Mattman and “cell wall deficient”.

    That’s my advice. I could speculate more on your questions but don’t want to lead you astray.

    Best,

    Amy

  114. Amy Proal March 19th, 2009 at 3:31 pm 114

    Hi Melinda,

    I think your vitamin D test results, overall reaction to vitamin D, and presence of chronic symptoms of “unknown” cause suggest that you are an ideal candidate for the Marshall Protocol.

    I think what you mean is that your 25-D is 13. That number definitely suggests that your vitamin D system (which controls the immune system) is being dysregulated by chronic bacteria – the same bacteria causing your disease symptoms. The following section of an article describes why a low level of 25-D is a sign of bacterial infection:

    http://bacteriality.com/2007/09/15/vitamind/#3

    A 1,25-D level of 38 is also consistent with the level we see often in patients who respond very well to the MP.

    That you cannot tolerate vitamin D is another huge sign that you are reacting as people on the MP do to vitamin D and that the treatment will work for you.

    So I greatly urge you to start the MP. If you are not sure what it involves the following two articles describe it in simple terms:

    http://bacteriality.com/about-the-mp/

    http://bacteriality.com/2007/10/11/antibiotics/

    I highly recommend you watch this video, which in my opinion, gives the best overview of the MP and science that forms its backbone:

    http://bacteriality.com/2008/05/07/mpintro/

    It sounds like your current doctor is open to putting you on the MP is great. Perhaps before doing so he would like to read Dr, Marshall’s (and staff’s) latest peer-reviewed papers and conference speeches. You can find them here:

    http://mpkb.org/doku.php/home#publications_presentations

    Here is a link to the Phase 1 guidelines which provide the info necessary for your doctor to understand what medications to prescribe for you to start the MP:

    http://www.marshallprotocol.com/forum2/2275.html

    If you have questions about how to start the MP after looking at the above material, the best place to ask them is actually at the following website:

    http://www.curemyth1.org (Th1 refers to disease caused by bacteria hence the name). The patient advocates on the site, who are volunteers, will answer your questions free of charge. They are trained in helping people start the treatment.

    I hope this helps and in my opinion, the MP is definitely the option you should pursue now in order to get your health back.

    Best,

    Amy

  115. Zuzana March 19th, 2009 at 6:26 pm 115

    Hello Aimee,

    First of All, I would like to say that this page gives me so much hope. Let me introduce myself-I am 28 years old female from Czech republic. I have been suffering from sore throat, low grade fevers, muscle pain, have tender swollen lymp-node in my neck and groins, terrible headache and almost all the symptoms that are typical for CFS. I felt like this when I was 20-in that time I had really bad mono. It took me a year to got over it, but I was healthy and had a quality life since then. Since november 2007-i have been suffering again and my blood tests are all good and I am a bit desperate nowadays. It started with weird ?viral? infection.. and it has never stopped. I feel depressed and really really tired of it. I have read couple stories about MP-I know people who are on it even in my country-and I would like to ask you-if it would be a good idea to try it??
    Thanks for ou reply…

  116. Amy Proal March 20th, 2009 at 11:47 am 116

    Hi Furch,

    Yes, I am certainly glad that you didn’t read the Mercola article first. But unfortunately others will and get led astray. It’s a huge shame. I just hope people who read the piece are smart enough to realize that Mercola is writing based on speculation alone and admits to never even reading any literature about the MP. I don’t even think Dr. Mercola realized ARF has published more papers over the years or that Dr. Marshall now speaks at many important conferences. He apparently learned all he needed to know about the MP at the Chicago Conference which was years ago!

    Anyway, I’m so glad that you have read about the MP in depth and understand the science. Please spread your knowledge to others when you can.

    Good to hear from you!

    Amy

  117. Amy Proal March 21st, 2009 at 12:44 pm 117

    Hi Zuzana,

    I’m so sorry about your symptoms. I think I can empathize with what you are dealing with since when I was about 19 I started to suffer from pretty much the same symptoms you are describing. Like you, my symptoms would ebb and flow but eventually I ended up bedridden and permanently sick. I was so tired of being sick too – I just wanted it to end.

    I tried a lot of other treatments that did not work before starting the MP. Then, when I did start the MP I immediately reacted to the therapy. You have probably read that the MP targets chronic bacteria that are thought to be the cause of CFS and related inflammatory diseases. When the MP medicines kill these bacteria toxins and cellular debri are released, causing a temporary rise in disease symptoms. The reaction in called immunopathology. I managed immunopathology for several years but as I did so the symptoms of my CFS began to disappear. I started to feel a strong sense of resiliency that I had never felt before. Today I am a different person. I live a normal life and will be beginning school against next fall.

    So I can’t recommend enough that you also do the MP! It’s difficult to deal with the immunopathology, but in my eyes doing so is completely with it because you are targeting the root cause of your disease. This means that when you kill all your bacteria you are completely healthy again and can get your full life back.

    If you want to review the MP and the science that forms its backbone I recommend that you watch the following video that describes it in simple terms:

    http://bacteriality.com/2008/05/07/mpintro/

    Also, here is a list of Dr. Marshall and team’s published papers and conference abstracts that you and your doctor may want to read:

    http://mpkb.org/doku.php#publications_presentations

    Also, if you have more questions about the MP a good place to ask them is at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria, hence the name). The patient advocates on the site, who are volunteers, will answer your questions free or charge and also help guide you in starting the MP.

    So I say yes, definitely give the MP a try…you have nothing to lose and much to gain!

    Best,

    Amy

  118. colleen March 26th, 2009 at 10:54 pm 118

    I’ve had Chronic Fatigue for 30 years. I have adjusted my life minimize stress, have not been able to hold a full time job, work at home part time, resting before and after each activity etc.

    I have chronic sore lymph nodes (although they were much worse in the first 10 years of so) and have ache all over fatigue and wired but tired feelings (although the fatigue early on was felt more like “dead weight.”)

    Do you know of any doctors in my area, Southwest Virginia that are aware of the MP and can help patients with treatment?

  119. Amy Proal March 27th, 2009 at 12:51 pm 119

    Hi Colleen,

    Ugh, sounds familiar. I dealt with those symptoms when I had CFS. Especially the swollen lymph nodes. They seemed SO swollen to me, like I could barely swallow, but when I showed them to doctors they would tell me they were hardly inflamed. Perhaps that’s not the case with you, but it was with me.

    Anyway, back to your actual question! The best way to find an MP doctor in your area is to request a list of MP doctors in your state at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria, hence the name). The patient advocates on the site will give you the list for free. They also answer questions about the MP free of charge.

    If the list indicates that there is not an MP doctor near where you live, you might want to try to convince your current doctor or an open-minded doctor in your area to put you on the treatment. If so, be sure to show him/her the following list of Dr. Marshall and team’s peer-reviewed papers and publications which they will almost certainly want to consult:

    http://mpkb.org/doku.php/home#publications_presentations

    Good luck and if you don’t find a doctor off the list don’t give up! Ask around on curemyth1.org for other people on the MP who live in Virginia and they may provide you with info not on the list.

    Best,

    Amy

  120. Ana Lisa April 6th, 2009 at 11:24 am 120

    I have had CSF for many years… is there any treatment centre in the North West of the Uk?
    thanks A

  121. Paul Albert April 6th, 2009 at 4:34 pm 121

    Hi Ana Lisa,

    I would recommend posting your request for an MP physician on CureMyTh1.org where volunteer patient advocates will answer your question.

    Best,
    Paul

  122. Glenn April 28th, 2009 at 11:34 pm 122

    Hi Amy,

    Sort of an off topic question. Would this theory also apply to animals? I have a friend with a very sick kitten. The diagnosis is FIP (feline infectious peronitis) from the vet.

    I believe most of not all illness is caused by a host of microbes and their toxins but was wondering if we could somehow adjust the MP for the kitten?

    Sincerely,
    Glenn

  123. Paul Albert April 30th, 2009 at 9:22 am 123

    Hi Glenn,

    This is Paul. I’m helping Amy answer some of her questions.

    I looked up FIP. Apparently, it is a serious disease and, according to Cornell’s vet school, “almost always fatal.” Cornell’s page says that FIP is caused by coronaviruses and has an inflammatory process. I don’t know much about a cat’s Vitamin D Receptor, but the coronavirus may be allowed to proliferate because of a dysregulated Vitamin D Receptor.

    It’s really hard to say how your friend’s kitten would react to the MP, namely the Benicar and the minocycline. The best way to see if it works is to try via a therapeutic probe. As for adjustments, I might try it based on body weight. Kittens are about five pounds, right? Maybe you could shoot for a fifteenth of the human dose?

    If you try, let us know what happens.

    Best,
    Paul

  124. Amy Proal April 30th, 2009 at 11:30 am 124

    Hi Glenn,

    This is Amy. It’s so sweet of you to make such an effort for the kitten’s health!

    Although it might work in theory, putting a kitten on the MP seems quite difficult. First off, I’m not sure how you would get the medications. I doubt a veterinarian would prescribe them to an animal. Also, as you probably know the MP causes a rise in disease symptoms and inflammation as it kills the bacteria causing an illness. This exacerbation of disease symptoms in the kitten would be hard to control and I think you would have great difficulty telling if the kitten was suffering too much.

    Also, Benicar works to activate the immune system by activating the Vitamin D Nuclear Receptor. However, I believe the cat and human Vitamin D Receptor are very different. So Benicar might not even be able to bind the receptor in cats and work the same way it does in humans.

    All in all, I suppose you could try an experiment of putting your cat on some very low dose Benicar but I have no idea if the kitten would benefit.

    Hopefully in the future we will be able to adapt the MP officially in a way that can be applied to pets but right now we have no experience when it comes to treating pets.

    Best,

    Amy

  125. Kari May 8th, 2009 at 1:52 am 125

    I am 44 years old and just went in for a physical. I have been more tired than usual. I asked for my Vitamin D level to be checked. My results were: 27.4 for 25-hydroxy and 106 for 1-25 dihydroxy. The 106 number seems extremely high. What are the ramifications?

  126. Paul Albert May 8th, 2009 at 9:53 am 126

    Hi Kari,

    Good to hear from you. You’re right. Depending on the units, 106 is either very high or extremely high. For you or anyone else who has vitamin D lab work they would like interpreted, you can use our Vitamin D metabolite calculator. It’s really nifty.

    As the Calculator suggests, a high 1,25-D is an indication of a dysregulated Vitamin D Receptor. This is a little sciency, but the Knowledge Base (still a work in progress) explains how 1,25-D is upregulated in people with chronic inflammatory diseases. The main implication here is that you would be a good candidate for the Marshall Protocol.

    Best,
    Paul

  127. Tara-Leigh haines May 12th, 2009 at 12:44 pm 127

    How do i find a doctor to do this protocol? I am in the Philly area

  128. Paul Albert May 14th, 2009 at 9:39 am 128

    Hi Tara-Leigh,

    Post your request at CureMyTh1.org.

    Also, have a look at our Knowledge Base article on finding a physician.

    Best,
    Paul

  129. Melissa J May 24th, 2009 at 8:01 pm 129

    hi

    i have to say, that i am on phase 3, well just started, and yes it has been hell, with all the neuro stuff, but interesting reading about the candida, as that was one of the first things that cleared up, and it was systemic with me, and i tried everything to get rid of it, but the MP certainaly has done that, the only thing i hope it fixes now is, that my body goes into melt down just before my period, the day and night before, is hell, burning brain, and pins and needles in the brain, internal tremors, lots of muskoskelital pain, but all stops when i first spot, so i am hoping the MP fixes that, other wise roll on menapause lol. but other than that, the light sensitivity and all the neuro stuff, like the shakes and seizure like symptons have gone

    Melissa

  130. Paul Albert May 24th, 2009 at 9:26 pm 130

    Thanks for sharing, Melissa. Your experience is very common. A lot of people find that their symptoms resolve at different rates. That was certainly true for me. Hang in there!

    Best,
    Paul

  131. Kim Taber June 2nd, 2009 at 10:44 pm 131

    How do I find a physician in my area that uses the Marshall Protocol?

    Boca Raton, Fl. 33433

  132. Paul Albert June 2nd, 2009 at 10:47 pm 132

    Hi Kim,

    Post a request at CureMyTh1.org. If you have any problems, do let me know.

    Good luck!

    Best,
    Paul

  133. Sylaah Crosdale June 24th, 2009 at 5:25 pm 133

    Hi my partner has had sarcoid living in him for the past 13 years, moving through every part of his body, from eyes, lungs, heart and now his brain. I can’t explain the effects this is having on his, well the both of us, the strain is immense. I am still of the hope that there is something out there that can help him. He has tried many medications which seem to affect him in their own way. Do you know if there is an MP doctor here in the UK. I look forward to hearing from you soon.

    Sylaah

  134. Sylaah Crosdale June 24th, 2009 at 5:30 pm 134

    Hi
    Can you advise if there is an MP doctor in the UK please?

    I look forward to hearing from you soon.

    Sylaah

  135. Amy Proal June 25th, 2009 at 10:10 am 135

    Hi Sylaah,

    I’m so sorry that your partner is suffering so greatly from sarcoidosis. Despite the face that many doctors claim that sarcoidosis is confined to certain areas of the body, we have seen that it can be a completely systemic illness.

    There are people on the MP in the UK. The best way to find an MP doctor in your area of the UK is to post at the following website:

    http://www.curemyth1.org (Th1 refers to diseases caused by bacteria, hence the name). The patient advocates on the site, who are volunteers, should provide you with a list of doctors using the MP in the UK.

    If none of the doctors on the list are taking new patients or in your area, I recommend trying to convince your partner’s current doctor or an open-minded doctor in your area to put him on the treatment. Showing such a doctor Dr. Marshall and team’s peer reviewed papers and conference speeches would be very important. You can find them here:

    http://mpkb.org/doku.php#publications_presentations

    This article also offers tips on how to find a doctor who will administer the MP:

    http://mpkb.org/doku.php/home:starting:physician:finding

    Good luck!

    Amy

  136. Amy Proal June 25th, 2009 at 10:11 am 136

    Hi Sylaah,

    I responded to you other post.

    Best,

    Amy

  137. Jamie June 30th, 2009 at 7:13 pm 137

    Dear Amy,

    I am trying to encourage my sister to review this process and consider it. She is suffering from lung disease and sarcoidosis. But nothing the doctors are trying is help her. Do you have a suggestion of the best way to go about finding a doctor who would support the MP? Are there lists anywhere, or do we need to just read up on it and print information and start asking physicians?

    Thank you for your help.

    Jamie

  138. Paul Albert June 30th, 2009 at 8:29 pm 138

    Hi Jamie,

    Have a look at the relevant Knowledge Base page:
    http://mpkb.org/doku.php/home:starting:physician:finding

    There’s lots of other helpful articles in the KB too.

    Best,
    Paul

  139. bchilton2 July 6th, 2009 at 10:37 am 139

    last year there was a doctors list on this web site, I can’t find it? How do I find a Dr. in my area to help me with the MP?

  140. Arnold Larsen July 6th, 2009 at 9:43 pm 140

    Hi Amy –

    What is humanity’s main source of information about Vitamin D? It’s probably Wikipedia. So if you would like to inform the greatest number of people, post your facts and theories on Wikipedia.

    I read the information about “Vitamin D” at Wikipedia.org and was left the the feeling that it was like a commercial for Vitamin D supplements. There was no mention of any controversy about the effects of Vitamin D on the body, nor was any minority opinion expressed.

    Some of the information is obviously wrong. For example, the second paragraph states that “It is also needed for bone growth and bone remodeling by osteoblasts and osteoclasts.” This is contrary to what Calcitriol (the active form of Vitamin D) does – see “Calcitriol” in Wikipedia. Vitamin D increases the flow of calcium into the blood from the gut, bones, and kidneys, it does NOT increase the flow of calcium INTO THE BONES!

    The consequences of more calcium flow into the blood is more calcium excretion from the body in the urine. Looks to me like a recipe for increased osteopenia, osteoporosis, and kidney stones.

    Unfortunately, I don’t know how to post information in Wikipedia. Could you please add the correct information about Vitamin D in Wikipedia.

    Thanks much — Arnold

  141. Amy Proal July 9th, 2009 at 12:43 pm 141

    Hi,

    There has never been a doctor’s list on this website. Instead, I have always directed people to http://www.curemyth1.org.

    The patient advocates who monitor the site should be able to provide you with a list of doctors who might put you on the MP in your area.

    Best,

    Amy

  142. Richrd Caradine July 9th, 2009 at 2:09 pm 142

    My wife has been diagnosed with sarcoidosis. She stay at the hospital more than she stay at home, we are looking for some serious help and don’t know where to start. Can someone please get us going in the right direction, the predinsone, loratab, etc. isn’t doing her a bit of good. we need help in this in the name of Jesus there has to be a cure somewhere.

  143. Jamie July 9th, 2009 at 6:10 pm 143

    Thank you Paul and Amy for your help.

  144. Paul Albert July 11th, 2009 at 3:17 pm 144

    Hi Arnold,

    Thanks for your comment. I agree that Wikipedia and numerous other sources are “overly exuberant” in their endorsement of vitamin D supplementation. In my opinion, there will come a time when a lot of these experts will look very foolish. Fortunately, we live in the age of the Internet when nothing ever quite goes away.

    Speaking for myself, my more immediate goal is to convince *researchers* of the validity of this work. As that begins to happen, everything will follow. There are simply too many papers extolling the virtues of vitamin D supplementation that convincing a well-read individual is too much of an uphill battle.

    Believe me, if I changed the Wikipedia article, I would start a protracted edit war. At this point, in my life, I really don’t have the time for this type of tug of war.

    In the next few years, I anticipate/hope there will be additional evidence supporting the explanations here and that someone will make the changes to Wikipedia for us.

    Best,
    Paul

  145. Paul Albert July 11th, 2009 at 4:11 pm 145

    Hi Richard,

    Sorry to hear about your wife. One option for her is the Marshall Protocol. These links are a good starting place:
    http://mpkb.org/doku.php/home:patients:protocol_overview
    http://autoimmunityresearch.org/phase1.pdf
    http://mpkb.org/doku.php/home:starting

    Best,
    Paul

  146. Ian Cameron August 18th, 2009 at 4:54 am 146

    Hi Amy,

    I have general inflammation of the left TMJ and the surrounding tissues, including the Trigeminal Nerve, every few days. The inflammation is bad every second day. After a very bad day, the inflammation almost disappears completely. It’s very odd. Do you know what is happening here? Do you think the MP would be worth a try?

    Thanks, Ian (Australia)

  147. Ian Cameron August 19th, 2009 at 1:42 am 147

    Hi, If the L-form bacteria are in the macrophages of the immune system, why is it that certain sites of the body become inflamed and painful? Why is it that some people get inflammation of the eye, others get inflammation of the wrist, others get inflammation of the bowel, others get inflammation of the tmj, others get inflammation of the spine, others get inflammation of the skin etc…etc…?? Is it our genes that determines where we will get inflammation in the body?
    This is fascinating…I think MP could be a major breakthrough in medicine!
    Thanks,
    Ian

  148. Paul Albert August 23rd, 2009 at 12:39 am 148

    Ian,

    We point to inflammation and corresponding pain and symptoms as an indication that the body is fighting an infection. You can take away the inflammation with drugs like TNF blockers but bacteria persist more than ever.

    Here’s an article that explains our view on variability in disease:
    http://mpkb.org/doku.php/home:pathogenesis:successive_infection

    Best,
    Paul

  149. Paul Albert August 23rd, 2009 at 12:43 am 149

    Ian,

    Symptoms do tend to wax and wane. For more on that, see my other comment to you. I absolutely think you should try the MP. Here’s an article that can be of use to prospective patients such as yourself.
    http://mpkb.org/doku.php/home:starting

    Best,
    Paul

  150. Ian Cameron August 28th, 2009 at 3:36 am 150

    Thanks Paul,

    I started on the MP with a 20mg of Benicar every 6 hours just to introduce my body to it. Then on day 4, I took the prescribed 40mg of Benicar and felt very faint and weak. My blood pressure probably dropped too low. But I was Ok taking 20mg of Benicar. Have people had similar problems on Benicar? Is MP still effective on 20mg of Benicar every 6 hours?

    Cheers,
    Ian

  151. Amy Proal August 29th, 2009 at 12:13 am 151

    Hi Ian,

    Low blood pressure is very common when starting the MP. It’s infrequently related to olmesartan. I recommend reading the following articles so you can get a better idea of where were coming from when it comes to Benicar:
    http://mpkb.org/doku.php/home:mp:mpmeds:olmesartan:response
    http://mpkb.org/doku.php/home:symptoms:hormonal:blood_pressure

    If you want, you can take 20 mg every 6 hours, however, we don’t have enough experience with patients taking less than the recommended dose.

    As I think the KB articles state, some patients take a week or two to adjust Benicar. That was certainly true for Paul.

    Best,
    Amy

  152. slimpauli September 5th, 2009 at 1:25 am 152

    Hello, Finding this site may be the answer to my prayers. Going to Thailand 5+ yrs ago , I have experienced severe burning sensations from the front of my genitals through and out of my anal canal. It can be triggered by certain foods. I am also experiencing brain fog and a sensitivity to light. Have been diagnosed as PID. (wrong)- Had a hair sample that indicated L- forms of bacteria-(Probably right). Had a mycoplasma multi-plex done on urine (not accurate) which came out neg. Is the MP right for me ?

  153. Amy Proal September 5th, 2009 at 2:32 am 153

    Hi,

    It sounds like you might be a good candidate for the MP. The most valid way to know if you are suitable is to do a therapeutic probe:
    http://mpkb.org/doku.php/home:starting:therapeutic_probe

    As a matter of fact, a number of researchers are currently looking at the role bowel infections play in chronic disease.
    http://www.genomeweb.com/nih-awards-42m-more-human-microbiome-studies

    Best,
    Amy

  154. slimpauli September 6th, 2009 at 11:30 pm 154

    Hi Amy, I am planning to pursue the protocol shortly. I must see my infectious specialist first.My condition has advanced to the point I am not producing any mucous in my nasal passages. I have read about moxilfloxacin, but it seems to be a last ditch effort, when all other course’s have been exhausted.Is a full year or two compulsory for your protocol, or have some patient’s recoverd more rapidly? I’m grateful for your presence on the net, and will share my progress on these postings.Blessings to you and your staff , you are to be applauded, Sincerely, Paul.

  155. Eddie Garrett September 15th, 2009 at 7:02 pm 155

    Thank you Amy, for the articles on sarcoidosis and the L-form bacteria. I was prescribed prednisone to take; but have learned that prednisone slows down my immune system to the point yhat the mutated bacteria can not be killed. If my doctor is not imformed or familiar with the ( Marshall Protocol )
    treatment or Benicar, do I need a prescrption to get started?

  156. Amy Proal September 16th, 2009 at 9:55 am 156

    Hi Eddie,

    I’m very glad you are considering your MP and hopefully skipping the prednisone!

    Have you read this article about Prednisone, just in case you need more info about why we suggest you shouldn’t take it?
    http://mpkb.org/doku.php/home:othertreatments:corticosteroids

    As for your question, you will need to get prescriptions from your doctor for Benicar (the medication used by the MP to activate the innate immune response) and the various MP antibiotics.

    The following treatment guidelines should help your doctor understand what medicines to prescribe to you and when:
    http://autoimmunityresearch.org/phase1.pdf

    If you find that your insurance company doesn’t cover four pills of Benicar a day (some do, some don’t) then you may want to order your Benicar from Canadian pharmacies that offer the drug for a lower price. You still need a prescription to buy the Benicar but you fax it to them. Here is contact info for some of the Canadian pharmacies:
    http://mpkb.org/doku.php/home:mp:mpmeds:olmesartan:buying

    Don’t forget that if you have questions about how to start the MP or manage your immunopathology as time goes on you can also post comments at http://www.curemyth1.org where such questions will be answered free of charge by patient advocates.

    Take care,
    Amy

  157. Dina October 5th, 2009 at 3:40 am 157

    Hi…i’ve been some of the success stories about beating this frightful disease…a firend of mine is in a very bad condition because of it and she is now unable to move or walk or even sit…her whole neuro system is affected and sometimes she finds difficulty in sensing her legs…we are afraid that she will become paralyzed during time…she is taking all necessary treatments but doesn’t know if her nerves and muscels can be back to mormal again…please tell me how can we help her and what kind of rehab can she make…

  158. Amy Proal October 5th, 2009 at 8:49 pm 158

    Hi Dina,

    I am so sorry to hear about how sick your friend has become. We help patients with sarcoidosis called the Marshall Protocol, but generally the treatment has to be started before the disease process gets too severe. While you’re welcome to read about the Protocol on this site, I’m not sure if your friend would be able to manage it in her current state. Otherwise, I would encourage you to make sure she is seeing a doctor and make sure she is getting adequate medical care for all her symptoms including possible paralysis.

    Best,
    Amy

  159. Ken October 7th, 2009 at 4:32 pm 159

    Amy,

    I’m one of the patients who has not been able to complete the Marshall Protocol because of severe symptoms including an intestinal blockage, two colon blockages and colon cancer. You may already know about my situation. Perhaps, my Crohn’s disease was too advanced before starting the protocol. Even when on Benicar alone (no antibiotics) I got severe immunopathology when I started the protocol 4 years ago. I was not aware of much of the immunopathology over the years because there were no symptoms until it was too late (ex. gastrointestinal blockages).

    The Marshall Protocol depends on the immune system to destroy the bacteria that are down-regulating immunity. Unfortunately this causes immunopathology that for some very ill patients can become life-threatening. Could there be a way of destroying these pathogens without invoking an inflammatory response? There are many examples of apoptosis being induced by phytochemicals in malfunctioning cells without the aid of the immune system (except to remove the resulting cellular debris). Salvestrols induce apoptosis in cancer and pre-cancerous cells as well as vitamin C and K in high doses.

    Ken (kenc)

  160. Amy Proal October 7th, 2009 at 7:30 pm 160

    Hi Ken,

    Sorry I’ve taken so long to get back to you. You make a good point – some people may have too high a bacterial load to be able to successfully manage the immunopathology needed to recover from their disease state. I’m very sorry if this has been the case for you.

    In terms of treatments that could kill chronic bacteria without generating immunopathology – I am intrigued by the possibility that drugs could be created that would interfere with bacterial communication in biofilm. I suspect that much of the bacteria in autoimmune/inflammatory disease is in a biofilm state. However research to create such drugs is still in a preliminary state. Although researchers are working to better understand quorum sensing (the process by which bacteria emit chemical molecules in order to communicate) I’m not sure any drugs are in the pipeline. If they are, I would be Bonnie Bassler’s group at Princeton would be leading the way. You may want to read more about her research.

    Take care,

    Amy

  161. Ken Furber October 14th, 2009 at 3:09 am 161

    Amy,

    First I would like to thank you for taking time out of your busy schedule to answer peoples questions on here and for the concise well written article posted above.
    Anyway, before I ask my questions I’ll give you a little background on my case. I have been suffering from Lyme Disease for the past 38 years, although I was only correctly diagnosed 2 years ago. It first presented itself with the typical bulls eye rash when I was just 12 years old. Unfortunately I never went to the doctor at that time. Of course now that I think about it even if I had gone it probably wouldn’t have made a difference as Lyme Disease had not even been identified back in 1971. Anyway the rash eventually went away and I forgot about it but by the time I was 14 I was suffering from severe constant headaches, severe fatigue, inability to concentrate and a myriad of other bizarre symptoms. The symptoms were so bad in fact that I was unable to even finish High School despite being an extremely intelligent and determined person.
    I must have seen at least 30 doctors over the years to try and find out what was wrong but they all just told me I was fine and acted as if it were all in my head. I eventually gave up hope and decided I would just have to live with it. Then a few years ago for some reason my symptoms began to worsen and I also got some new symptoms. I decided I had to give the doctors one last try so I flew to Seattle to see a doctor who specializes in hard to solve cases. After talking to me for an hour and going over my symptoms he said he was almost certain I had Lyme Disease. I had never heard of Lyme disease before and I had my doubts about his diagnosis but sure enough the tests came back positive for both Lyme and Babesia. It was great to finally have an answer after all those years but as I studied up on the disease it became apparent that there was no quick fix for this one and I was looking at years of treatment.
    After starting antibiotics my IP symptoms (Herx.) became so bad that I imagined Heroin withdrawal would probably be a walk in the park in comparison. I went through 6 month of constant round the clock excruciating torturous pain and nausea. Despite this though I never missed a single dose of medication in all that time. Once I decide to do something I just wont quit even if it kills me. With no insurance though and after spending $15,000 on antibiotics I had no more money to continue treatment. I tried to tell myself that at least I would feel better due to a cessation in IP symptoms. To my horror though my symptoms remained unchanged even after I stopped the antibiotics. All they did was permanently kick the disease into high gear. Now I am bedridden most of the time and can no longer work or support myself. I take percocet for pain when I can get it but even when on the pain meds the pain is sometimes so bad that I think about killing myself simply to stop it. I’m not depressed or “suicidal” in the classical sense of the word but the physical pain is just too much to bear at times and it seems there is no other way to stop it.
    Anyway after reading Dr. Marshals research I have decided that the MP is clearly the best way to go if I want to have any chance of regaining my health. Also because the doses of antibiotics are so small I will be able to afford them even on my limited budget. I have already stopped taking all supplements and have eliminated all sources of Vitamin D from my diet. I have a few questions before I start the program though.
    1. Will the oxycodone I take for pain reduce the effectiveness of the MP and if so are there any alternative pain medications that will work with it?
    2. Will the presence of Babesia affect the outcome of the MP, assuming of course that the 6 months of Mepron did not completely kill off this particular infection?
    3. How can I find a Doctor to prescribe the MP meds? I had to leave California to stay with relatives in South Carolina and I have no Doctor here at all.

    Ken

  162. Lisa October 15th, 2009 at 4:08 pm 162

    This is for Ken Furber…my husband started the MP last Oct for late stage Lyme…he did not get past the first phase…we eventually ended up at a Fibromyalgia and Chronic Fatigue Center (they are nationwide and familiar with MP!!) I would urge you to visit http://www.fibroandfatigue.com . When my husband got there, he was in adrenal fatigue, had thyroid problems, many hormones were low or not even detectable and he had active Epstein Barr (mono) on top of Lyme Disease…basically his body was wiped out after trying to fight Lyme for so many yrs…they have helped him improve, slowly but surely…he was where you are…there is hope…God bless!

  163. Paul Albert October 19th, 2009 at 10:28 am 163

    Hi Lisa,

    The obvious question for me is why your husband “didn’t get past the first stage.” Did he lower his antibiotics when his symptoms increased? If he was photosensitive, was he avoiding light? If I’m not mistaken, Amy went to the F & F for two years before she decided she wanted to treat the underlying disease process using the MP.

    Best,
    Paul

  164. Amy Proal October 19th, 2009 at 11:44 am 164

    Hi Ken,

    I urge you not to take Lisa’s advice, and Lisa I advise you to speak with more caution when you tell people not to do the MP.

    As Paul commented, why did your husband stop the MP? He did realize that he needed to experience a bacterial die-off reaction in order to gradually eliminate the pathogens causing his disease? This reaction causes temporary rises in inflammation and disease symptoms but is imperative if one truly wants to recover from inflammatory disease.

    I saw a doctor at the Cleveland Fibromyalgia and Fatigue Center for three years before starting the MP. I credit their treatments with radically exacerbating my illnesses. They basically stuck me with a bunch of drugs that supposedly “boosted” my body but in reality suppressed my immune system. I came into the Center with a moderate case of CFS and left bedridden. So obviously, they are one of the last places I would advise anyone to seek treatment.

    Best,

    Amy

  165. slimpauli October 19th, 2009 at 6:08 pm 165

    HI Amy and Paul, I sent a hair sample to Minn. via Colo., which uses a zyto-cradle to analyse the pathogens I am infected with. 15 molds and fungi-5 parasites (protazoa-malaria) also. And finally what he said was a serious L-form of bacteria presence. I had extreme burning from front of genitals to rectum on and off for 5 years since a trip to thailand. I have suffered through years of joint pain,fatique and extreme stress. Is this technology valid in your opinion?

  166. Lisa October 19th, 2009 at 7:58 pm 166

    Amy and Ken, First Amy, I do not appreciate the tone in which you repsonded! Your wording, “I advise you to speak with more caution when you tell people not to do the MP,” is inappropriate as I did NOT say not to go on the MP. I fully support the MP but it cannot cure everything if there are other issues involved like in my husband’s case. I advise you to REREAD my post because I was merely trying to help Ken find doctors that know and use the MP and they do know and use the MP at F & F centers. Being the caregiver is stressful enough and your email today added to my stress level. Best wishes to you Ken! Amy, I am sorry to hear F & F didn’t fully help you but am happy you are better. As for us, we are still struggling and slowly improving…MP may be in the future again (I certainly wish Phase 2 and 3 were more easily available…that was another issue for us as our provider did not go to the website for it when we needed it…Ken, my husband did decrease the antibiotic and increase the Benicar…we did everything right…the other health issues surfaced and needed to be addressed…the new doctor did not proceed with MP but may in the future.

  167. Ken Furber October 20th, 2009 at 4:12 am 167

    Amy & Lisa,

    Lisa – thank you for the information and for your support. I’m sorry to hear that your husband was unable to complete the MP. Unfortunately curing Lyme Disease and other similar conditions is really one of those “no pain no gain” scenarios and some people simply will not be able to get through the pain. In any case I hope whatever treatment your husband is receiving now turns out to be helpful.
    As for Amy’s remarks I’m sure she did not mean to put you down or make you feel bad. You are right though, you’re message never actually stated that I should not use the MP. I’m afraid written communication is just too easily misunderstood.

    Amy – not to worry, even if someone had tried to steer me away from the MP they would not have been successful. I have always been my own advisor and am not easily swayed by the opinions of others. I look at all the facts and arrive at conclusions based on those facts. My decision to start the MP is based on the soundness of the scientific principles behind it, not on how well anyone thinks it may or may not have worked for them. After all, if I were making my decision based solely on the highest percentage of purported success stories by individuals posting their stories on the internet then I would probably be using Rife therapy or Hyperbaric Oxygen Therapy. The problem with Rife machines of course is that even if the original ones worked as claimed, which is certainly possible, there is no way to know if any of the Rife machines sold today will do what the original ones did. There is no regulation over the industry so you could end up paying thousands of dollars for a piece of junk that does nothing at all. And while HBOT clearly makes most people feel a whole lot better there is no evidence that it does more than relieve symptoms at this point. We need more long-term studies to see if it’s an actual cure for Lyme Disease or not. In any case the cost alone prevents it from being an option for me.
    The bottom line is there is simply no therapy out there where patients are clearly having positive results in nearly every case. This is why I don’t make treatment decisions based on what this or that person says helped them.
    Bye the way, you forgot to answer my questions in your last posting. Anyway I already found the answer to question No.2 in one of your lectures. You stated that co-infections like my Babesia will resolve themselves on the MP and do not have to be handled separately. As for the other two questions I think I can find the answers on my own.
    Anyway you and Lisa need to kiss and make up or else I’ll have to send you both to bed with no milk and cookies :)

    Ken

  168. Paul Albert October 21st, 2009 at 8:36 am 168

    Hi Slimpauli,

    As far as I know, we don’t have any experience with that test, but if I were in your shoes, I would want to know what kind of evidence the lab can offer that l-form bacteria are present in hair. Personally, I’ve never seen a paper that says that l-forms could be detected in hair.

    We typically tell patients that the best way for determining suitability for the Marshall Protocol is a therapeutic probe:
    http://mpkb.org/doku.php/home:starting:therapeutic_probe

    You could also get you D levels tested:
    http://mpkb.org/doku.php/home:tests:vitdinterpretation

    Best,
    Paul

  169. Amy Proal October 22nd, 2009 at 4:09 pm 169

    Hi Ken/Lisa,

    Ken- I’m glad people like you are around to let me know when my reactions come off as way too harsh. I think I sort of freaked when I saw someone recommend the Fibromyalgia and Fatigue Centers on this site. They literally bankrupted my parents and propelled me towards disaster. The reason I was so abrupt, although I agree it was not the best strategy!, was because I really do care about your husband Lisa, and I hate to see him get treatment that I consider so counterproductive. But I apologize for my tone and I hope that if your husband is just seeking relief that he can get it from the drugs they administer at Fibro and Fatigue.

    Ken- You have a very practical attitude towards the MP and you seem like an excellent candidate.

    Sorry about not answering your questions!

    1. About the oxycontin. Many people on the MP take painkillers, including opioid meds. I took Tramadol for several years on the MP and did fine. As long as you feel you are still experiencing immunopathology despite taking the oxycontin, I think you should be fine. Obviously if you begin to feel like your symptoms arn’t very strong you could try weaning from the drug as maybe you don’t need it anymore..but that could take some time. Oxycontin and other pain meds may have a small immunosuppressive effect, but you can always induce more IP by raising your antibiotics if necessary.

    3. I don’t keep track of MP docs. Unfortunately, there are many more on the West coast than the East coast from what I’ve heard. First, go to http://www.curemyth1.org and ask for the doctor’s list for South Carolina. If none of those doctors work out (or there may not be many docs on the list!) then you need to convince an open-minded doctor in your area to put you on the treatment. Luckily, I feel you can explain the MP and why it would benefit you quite eloquently. This article gives tips about how to convince a doctor to put you on the MP:

    http://mpkb.org/doku.php/home:starting:physician:finding

    Hope this helps!

    Amy

  170. deck November 1st, 2009 at 2:34 pm 170

    Hello,

    I have been reading and learning about the treatment and diagnosis of “lyme disease”. I have stumbled upon the “Marshall Protocoll” and since it aims to treat conditions very similar to lyme disease, I would like to ask some questions regarding the proposed treatment options.

    I will briefly summarize some things relevant for my questions, most of it is propably not new to you, sorry if it gets long:

    Most CWD forms dramatically change their resistance to antibiotics compared to their “classical” forms, through the altered properties of their cell wall. Especially the complete lack of most of the characteristic OSP and reduced metabolism makes them hard to target with most antibiotics and even the innate immune system. Immunoglobulines will not attach, lymphocytes react only party, production of interferon-alpha by macrophages is reduced and so on.
    In case of Borrelia burgdorferi (Bb) the pathogen itsself has developed many highly effective immune evasion and supression mechanisms. Therefore, in treatment of Lyme disease, only high doses of certain Antibiotics in combination have shown to be effective and the “immune stimulation” thought to be most effective is the eradication of the pathogen by this treatments.
    Generally two different effects are sought to be reached by the chosen medication: Destruction or inhibition of growth of Bb in its’ spirochetal form and destruction of Bb in its’ CWD forms.
    For both effects, high intracellular concentrations have to be reached in all compartiments of the body.

    Now I will make it short and just say, that the medication found to be perhaps most effective is a combination of Tetracyclines or Macrolides (=> spirochetal form) with Hydroxychloroquine or Nitroimidazoles (CWD => forms).

    Since Bb was shown to build biofilms in vitro and in vivo, the antibiotic which gained the biggest importance is Minocyclin, which due to its’ relatively tiny size is thought to penetrate even biofilms. (furthermore it reaches the highest concentration known of an antibiotic in the liquor and skin, two of the major compartiments Bb inhabits)

    Now when I read about the MP, I was getting really curious, since it proposes some antibiotics widely used in treatment of (late) Lyme disease. But what I would like to ask:

    -As far as I know, neither Tetracyclines nor Macrolides have shown an effect on CWD forms of Bb. I suppose this will be the same for many other bacterial CWD forms (as shown in Lida Mattman’s “Stealth Pathogens”). How are these forms targeted in the Marshall Protocoll?

    -One of the reasons Lyme patients are given Hydroxychloroquin is that it raises the pH of the cytoplasm. Some antibiotics therefore reach higher intracellular concentrations. Is this effect relevant for MP?

    -How are biofilms targeted in the MP?

    -How is the immune stimulation by VDR mechanisms thought to affect CWD forms, which are in many ways invisible to the immune system?

    Thanks very much for your time!
    Many greetings,
    deck

  171. Julie November 6th, 2009 at 5:53 pm 171

    Hi, Amy. I have been looking into the Marshall Protocol recently. I’m 27 and have been sick for about a dozen years. I’ve had diagnoses of CFS, FMS, Lyme Disease and Bartonella, and autoimmune disease. So, I seem like a good candidate for the MP. The thing I’m really concerned about is that metformin is listed as one of the medications that you can’t take. I have polycystic ovary syndrome (PCOS) and take 2000mg of extended release metformin per day. Without the metformin, I can’t control my weight at all because the insulin resistance is so bad. The metformin controls my androgen levels and regulates my periods. I tried to go off the metformin because my former acupuncturist didn’t want me to take it, and my weight began to skyrocket. What should I do? Will the MP simply not work if I’m on metformin? Is there an alternative to metformin that I can take while doing the MP? Thank you so much for your time. -Julie

  172. Julie November 6th, 2009 at 6:06 pm 172

    Hi, Amy. I already tried posting once, and my comment disappeared. So, I’m going to try again. I also registered at CureMyTh1.org two days ago but haven’t received the email that I need to complete my registration, so I’m not sure how to proceed on that site.

    I have been looking into the Marshall Protocol recently. I’m 27 and have been sick for about a dozen years. I’ve had diagnoses of CFS, FMS, Lyme Disease and Bartonella, and autoimmune disease. So, I seem like a good candidate for the MP. The thing I’m really concerned about is that metformin is listed as one of the medications that you can’t take. I have polycystic ovary syndrome (PCOS) and take 2000mg of extended release metformin per day. Without the metformin, I can’t control my weight at all because the insulin resistance is so bad. The metformin controls my androgen levels and regulates my periods. I tried to go off the metformin because my former acupuncturist didn’t want me to take it, and my weight began to skyrocket. What should I do? Will the MP simply not work if I’m on metformin? Is there an alternative to metformin that I can take while doing the MP?

    Thank you so much for your time. -Julie

  173. Betty November 9th, 2009 at 7:11 pm 173

    I would like to know if there is any information about treating Lyme Disease concurrently with acute adrenal fatigue. My daughter is in her 3rd year of treatment for Lyme under the MP and has now been diagnosed with acute adrenal fatigue which calls for supplements and foods that are not acceptable under the MP. Is it possible that the MP treatment has contributed to the adrenal dysfunction?

    Thank you for your assistance.

  174. Amy Proal November 9th, 2009 at 9:17 pm 174

    Hi Julie,

    I got your post. Sorry for the delay in writing back – I was away this weekend. I’m really sorry you are suffering so much! Let me check with Dr. Marshall about the metformin and I’ll get back to you ASAP.

    Amy

  175. NickD November 12th, 2009 at 5:16 pm 175

    Hi Amy and all,

    Can taking any antibiotic specifically target just one microbe in the body? It appears that MP antibiotics, are meant to kill specific bacteria, but I fear that they might kill so called “beneficial bacteria” as well. Whether the MP antibiotics target beneficial bacteria or not, wouldn’t it be prudent to take a very high quality (50 billion organisms) probiotic with the MP?

    Dr. Mercola is just following his heart and according to you is wrong on vitamin D. After reading this entire article and comments, I do beleive that you are right and he his wrong on this issue. I wouldn’t throw the baby out with the bath-water, because he has some other very important products such as his high quality probiotic formula. I’m confident that he’ll eventually come around to see the light.

    Lately I have been listening to a full court press on the vitamin D front. The current mantra is that instead of getting the N1H1 vaccine, people should be tanking up on something like 12,000 IU of Vitamin/steroidal D3 a day!!! This I heard on the Frankie Boyer show http://www.frankieboyer.com/ according to Dr. Andrew W. Saul at http://www.doctoryourself.com/

    Dr. Saul recently said that he was disapponted that, even though he was taking 10,000 IUs of D3 a day, it wasn’t high enough for him after his test came back. Forgime if I don’t have his exact recommendation on hand, but I think it is something like in the 50 to 60 range for the 1,25 D.
    Because of this he is now taking 12,000 IU!!

    On my own problems, I am relatively very healthy, except that I have had persistent acne since I was 12 or 13. I’m 43 now and have never smoked and drink very rarely for the last 22 years.

    In the last 4 years I have changed my diet dramatically and learned about probiotics. I recently based on Dr. Saul’s and others recomendation picked up 5000 IUs of D3 and started to take it do to my lack of sun exposure, but I’m stoppong it right away, because of the obvious deletrious effect that it could have on me.

    I want to know if an MP doctor would allow me to go on this protocol even though I exhibit very few of the symptoms of CFS. I do however, feel that I am fatigued during the day when I know that I should not be. There is a tunnell that I go through in Boston (Thomas P. O’Neill Jr. Tunnel) that when I come out the sun is very bright and all of a sudden at 2 pm I feel like falling asleep right there at the wheel on the way home from work. I usually have to pull over at the nearest exit to take a short nap. I also have learned to turn the vent fan off so as not to be exposed to car exhaust while travelling through the tunnel.

    Regards,
    Nick D

  176. Paul Albert November 12th, 2009 at 6:34 pm 176

    Hi Julie,

    Have a look at our page on hypoglycemics:
    http://mpkb.org/doku.php/home:othertreatments:hypoglycemics

    Regards,
    Paul

  177. Paul Albert November 12th, 2009 at 6:37 pm 177

    Hi Betty,

    It is normal for symptoms to become worse on the MP.
    http://mpkb.org/doku.php/home:mp:progress#my_disease_is_getting_worse

    If your daughter’s symptoms are too severe, I would recommend working with your doctor to lower the doses of here antibiotics as suggested here:
    http://mpkb.org/doku.php/home:mp:managing_immunopathology

    Hope this helps!

    Best,
    Paul

  178. Paul Albert November 12th, 2009 at 6:57 pm 178

    Hi Nick,

    To a large extent, the MP is species-agnostic. That said, the goal of the MP is to activate the innate immune response, which is underactive in patients with chronic inflammatory disease. We believe that if you put a healthy person’s immune response in that of a sick person, you’d probably get the same kind of bacterial die-off.

    As far as I know, we’re not sure exactly how an activated immune response affects the “beneficial” bacteria. However, we would argue that it is not the “good” bacteria which make a person healthy but a strong immune system, which allow good bacteria to proliferate. It’s a matter of causation.
    http://mpkb.org/doku.php/home:othertreatments:probiotics

    Drs. Saul and Boyer are making some pretty bold claims. Of course, there is no evidence for that. Symptoms of flu and cold are unpleasant, but why would you deprive your body of the ability to rid itself of pathogens? Sorry, but an elevated temperature is exactly what a person needs when he acquires a harmful virus.

    When you talk about a range of 1,25-D being 50-60, I can only assume you mean ng/ml of 25-D. The active hormone 1,25-D tends not to be on these people’s radar, unfortunately. It complicates their thinking to consider how a person could have high levels of the active hormone of vitamin D when they are “deficient.”

    I know your symptoms are not as severe as others, but yours is exactly the right time to start the MP – right when symptoms are developing. Patients who are very sicker have a much tougher time on the MP. Keep in mind too that regular supplementation may have made you feel temporarily better by suppressing your immune system.

    Here’s a document on finding an MP doc:
    http://mpkb.org/doku.php/home:starting:physician:finding

    Hope this helps.

    Best,
    Paul

  179. Matthew November 12th, 2009 at 7:41 pm 179

    Hi,

    Forgive me but I am a little confused by your explanation of the pathophysiology relating to the VDR.

    First you state that 25-D and bacterial proteins block the VDR – deactivating the innate immune response. Ok, this makes sense to start us off.

    Next you say that if 25-D and bacterial proteins are blocking the VDR then 1,25-D cannot bind to the VDR. I am assuming 1,25-D has lower affinity? Although this would seem odd given that it is the active metabolite. But I am still willing to go along with you at this point.

    I follow you as you explain how the VDR blockade ultimately leads to elevated 1,25-D and low 25-D.

    It initially seems that elevated 1,25-D is the perfect explanation for the dysfunction seen in the endocrine system in “Th1 diseases” if as you say, at high levels it blocks the receptors for multiple hormones.

    But wait, this is where the theory seems to fall down like a house of cards for me. If the 1,25-D levels are now high enough to bind with hormone receptors it obviously has low affinity for – surely it would by now also be binding strongly to the VDR (its target receptor) again and activating the innate immune system – especially as 25-D is apparently now low and thus would not be blocking the VDR. With the innate immune response once again activated the disease would resolve itself…no?

    I am 30 and was diagnosed with CFS aged 12. I now for sure have multiple gut infections (yeast, bacteria etc) and God knows what else systemically. I am open to any treatment approach as long as the theory is sound and the treatment is proven.

    Could you therefore please explain why the VDR and innate immune system would remain inactivated with abnormally high 1,25-D (apparently binding to every other receptor type in sight) and low levels of 25-D (therefore not blocking the VDR).

    I very much look forward to hearing how this is explained.

    Many thanks,

    Matthew

  180. NickD November 12th, 2009 at 7:44 pm 180

    Thanks for the timely response, Paul!!

    I’m going to check MP out right after I figure out what “species agnostic” means. But seriously, I’m going to look into this and Steroid D is done. I’ll let you know what I find.

    Nick D.

  181. NickD November 12th, 2009 at 7:51 pm 181

    To All,

    Just a suggestion for those who are very sick and thinking of going on MP. Before you do, try a few preliminary steps. Start with the macrobiotic diet and something called the “lemonade master cleanser fast” to clean out the intestines. The faster you can move the crap through the instestines the better. Also, you might try the recommendations in DETOX OR DIE by Sherry Rogers, MD. At least you’ll be in the ballpark, then do MP.

    Peace,
    Nick D.

  182. Paul Albert November 12th, 2009 at 7:57 pm 182

    Sorry for the crappy explanation, Matthew.

    According to Dr. Marshall’s molecular modeling work, the 1,25-D and 25-D metabolites have equivalent affinities for the VDR. Whether one metabolite binds to a VDR depends on concentration.

    But – just because a ligand binds to a receptor doesn’t mean it activates it. By Marshall’s reckoning (I see no reason to doubt this assessment) ~97% of ligands do not activate the VDR. When levels of 1,25-D are high, those levels are immunosuppressive by interfering with the activity of *other* receptors – binding but not activating. Keep in mind, the VDR is just one of at least several receptors that transcribe antimicrobial peptides.

    Amy’s paper discusses this very thing in greater detail:
    http://autoimmunityResearch.org/preprints/ProalAnnals2009Preprint.pdf

    Also, have a look at this:
    http://mpkb.org/doku.php/home:pathogenesis:innate_immunity

    Regards,
    Paul

  183. Paul Albert November 12th, 2009 at 7:59 pm 183

    Species agnostic means we’re killing some pathogenic microbes, but we haven’t nailed down which kind(s) they are. :)

    Paul

  184. Matthew November 12th, 2009 at 8:05 pm 184

    Hi Paul,

    Thanks for the very rapid response!

    It just seemed contradictory to state that everyone agrees 1,25-D activates the VDR and innate immune system but that somehow in a situation where 1,25-D is high immunity is suppressed and disease ensues.

    I see more logic to it now you have explained further and hopefully everything will become crystal clear after I have read the articles you have suggested.

    Thanks again,

    Matthew

  185. Amy Proal November 12th, 2009 at 8:07 pm 185

    Hi Julie,

    I don’t think Paul realized you already know metformin is already contraindicated on the MP. I wish I could tell you it would be okay to stay on metformin while you do the MP, because I understand how difficult it is for you to have your weight increase. But, unfortunately the drug will interfere with the ability of the immune system to target the bacteria you’re trying to kill. It blocks two important cytokines, TNF-alpha and IL-6, which molecules that are very important for targeting bacteria.

    The MP is difficult for everyone in the sense that patients must face their symptoms before those symptoms are in time resolved. In your case, I feel that weight gain or a higher than average weight is one of the symptoms associated with your disease state. In this sense, if you’re going to kill the bacteria causing you to be heavier, you are probably going to have to deal with being heavier for at least a while on the treatment.

    You should be encouraged by the fact that some other people who have done the MP have found their weight has decreased over the course of the treatment and that scientists are increasingly attributing obesity and weight gain to the kind of bacteria that the MP targets.

    If it comes down to a decision between not doing the MP at all, because you don’t want to discontinue metformin, then I would recommend you do while on the drug. I don’t think the treatment would be as effective, but you might be able to make some progress, and that would certainly be better than any other types of immunosuppressive or palliative therapies. If this is the case, you might find that you could wean off the drug over time.

    Best,
    Amy

  186. NickD November 13th, 2009 at 1:23 pm 186

    Hi Amy and Paul,

    In response to one of the posters about an inadequate definition of Steroidal D, I took your information and inserted a CAUTION edit into the Wikipedia site as follows:
    http://en.wikipedia.org/wiki/Vitamin_D
    CAUTION
    Caution: Vitamin D is an immune suppressor. Vitamin D2 and D3 are not nutrients. They are mislabeled as “vitamins” on the ingredients of all vitamin supplement bottles. Taking high doses over a short period or low doses over a period of years can be detrimental to health far outweighing the so-called benefits. It is a steroid and as such, it competes for active immune response receptors in the body. Initially, taking Steroidal D2 or D3 supplements or getting it from prolonged exposure to the sun will make a person feel good, but in the long term this allows parasitic microbes to proliferate and multiply and migrate where they will colonize to various parts of the body. When the immune system is working correctly, it can kill these microbes and flush them out of the body. If the body is overrun with them, and the immune system can still deal with them, it kills off millions if not billions of them at a time. The waste products from this massive kill-off are what cause many symptoms in various parts of the body depending where the colonies are thriving and dying. You will feel better after taking Steroidal D2 and D3, because the immune system stops killing the microbes. However, these parasitic microbes begin to multiply exponentially and therefore, die off in very large numbers and symptoms magically reappear with a vengeance. By then it’s too late and Chronic Fatigue Syndrome among other seemingly untreatable debilitating ailments are the result.

  187. Amy Proal November 13th, 2009 at 3:07 pm 187

    Hi Nick,

    Wow! Thanks very much for taking the time to write that – it’s expressed very well.

    I warn you that it may be taken down – we have tried without success to alter sections of the Wikipedia vitamin D article before and had our comments erased.

    Did you cite our more recent publications on vitamin D with the comment? Make sure the following papers are cited, at least:

    http://www.ncbi.nlm.nih.gov/pubmed/19393200

    http://www.ncbi.nlm.nih.gov/pubmed/18200565

    Thanks again for your effort.

    Best,

    Amy

  188. NickD November 13th, 2009 at 4:53 pm 188

    Amy,

    That didn’t take long. The people who erased it are identified as: Swedish Medical Center, Seattle, Washington, USA.

    Regards,
    Nick D.

  189. NickD November 13th, 2009 at 5:32 pm 189

    Amy,

    Here is my second attempt. I placed it in the “overdose” section and edited it a little.

    I also sited this article at the bottom in the references. http://www.ncbi.nlm.nih.gov/pubmed/19393200
    I left a note for them to contact me before they simply erase it.

    Nick D.

    Vitamin D is an immune suppressor and steroid. Vitamin D2 and D3 are not nutrients like vitamins A and E and are mislabeled as “vitamins” on the ingredients of all vitamin supplement bottles. We have an obvious need for D, however taking high doses over a short period or low doses over a period of years can be detrimental to health balancing the benefits. Exactly how much is too high or how much is too low is not known. It is a steroid and as such, it competes for active immune response receptors in the body. Initially, taking Steroidal D2 or D3 supplements may make a person feel good, but in the long term this may allow parasitic microbes to proliferate where they will colonize to various parts of the body. When the immune system is working correctly, it can kill these microbes and flush them out of the body. If the body is overrun with them, and the immune system can still deal with them, it kills off millions if not billions of them at a time. The waste products from this massive kill-off are what cause many symptoms in various parts of the body depending where the colonies are thriving and dying. You will feel better after taking Steroidal D2 and D3, because the immune system stops killing the microbes. However, these parasitic microbes begin to multiply exponentially and therefore, die off in very large numbers and symptoms magically reappear with a vengeance. By then it’s too late and Chronic Fatigue Syndrome among other seemingly untreatable debilitating ailments are the result.

  190. Ken Furber November 14th, 2009 at 12:55 am 190

    NickD,

    Well my hat’s off to you for trying but if you want to get something on Wikipedia that contradicts what is accepted as fact by the dimwitted mainstream medical community then you are going to have to tread lightly and do it with a bit more tact. For example, instead of starting off by bluntly stating that Vitamin D is an immunosuppressive secosteroid, I would say something like: “Recent research conducted by Dr. Trevor Marshal suggests that Vitamin D may actually have certain immunosuppressive properties” or “There is a growing body of evidence to suggest that….blah, blah, blah, etc.”. This kind of wording is less likely to ruffle any feathers. It just needs to be short and sweet and non-threatening. Then, once you have piqued the reader’s curiosity, they can follow your links to other more detailed and direct articles. Anyway the bottom line is that whenever posting information on Wikipedia that is not “mainstream” you have to present it as though its just an alternative theory regardless of how solidly it may be grounded in fact.

    Ken

  191. NickD November 14th, 2009 at 1:02 am 191

    Thanks, Ken. I like a challenge. This will only make me want to study further to get my point across. I like your approach.

    Regards,
    Nick D.

  192. Ken Furber November 14th, 2009 at 4:00 am 192

    Amy,

    Sorry it took so long to get back to you but up until today I was much too sick to write or doing anything else for that matter. Anyway I just wanted to thank you for your reply and for all the info. Unfortunately though I still haven’t found that elusive “open-minded” doctor you spoke of to put me on the MP – not an easy task. Let’s face it, doctors by their very nature are very narrow-minded individuals. In fact, even the term open-minded doctor itself is somewhat of an oxymoron isn’t it? Doctors are people who are very good at memorizing facts and figures from textbooks (book smart) but most are not terribly intelligent or open minded. They take what they learn in school as the gospel and never bother to evaluate the data for themselves. They also seem to lack what most of us would consider to be the most important trait for a doctor to have, a diagnostic mind. It’s extremely rare to find a Doctor with diagnostic skills like the one who finally diagnosed me correctly. Most will just lazily run a battery of standard test and then tell you that you are fine when the tests come back negative. I suppose a good bedside manner might make up for some of this lack of abilities but they usually don’t even have that. Their uniformly bad attitudes toward their patients seem to run the gambit from sickeningly smug and patronizing to downright hostile. I think they are probably all so sick of constantly having to hear patients whine and complain all day about ever little ache and pain they have that they can no longer even stand to be in the same room with them. To tell the truth I probably couldn’t stand it either, but then again I didn’t decide to become a doctor now did I? The bottom line is, that’s the job, and if you cant manage to treat people with dignity and respect despite the constant whining and complaining then you’ve got no business being a doctor in the first place as far as I’m concerned. Of course even TV’s Dr. House doesn’t care about his patients but at least he cares about solving the puzzle. Real doctors don’t care about either.
    Whoa, sorry about that, it seems I got a little carried away there. This is supposed to be a place for answering questions about the MP, not for complaining about the medical profession. Anyway thanks again for all your help :)

    Ken

  193. NickD November 14th, 2009 at 1:51 pm 193

    Hi Amy Paul and All,
    I’ve been pooling a lot of information together for my discussion on Steroidal D (I suggest that from now on everyone completely drop the “Vitamin” label) and I took that info over Dr. Mercola’s Facebook site. Here is the short essay I wrote on there. http://www.facebook.com/doctor.health?ref=mf

    regards,
    Nick D

    Okay, here is why, if you have an autoimmune disease, then you should avoid Steroidal D (D is not a Vitamin) otherwise known as D2 and D3. Pathogens produce binders that attach to VITAMIN D NUCLEAR RECEPTORS (VDR). D2 (25-D) does the same thing. Both of them block D3. This stops the D3 (1,25-D) from doing its job on the VDR. D3 now will seek other immune receptors like the T3 receptors and bind to them not allowing T3 to do its immune function. Taking massive amounts of D3 will only inhibit your ability to fight the pathogens and heal.

    Okay. So now you’re worried. So you go to your doctor and test for D. He/she will probably do a D2 (25-D) test and tell you that it is low. They’ll tell you that nick is full of it and prescribe that you should increase your vitamin D intake!!! Just one minute, now. Before you leave the doctor’s office insist that you have them do a D3 (1,25-D) test. It will probably come back as off the charts high.

    Why is that, Nick? If you have an autoimmune disease, then the enzyme that is resposible for breaking down D3 (1,25-D) so that you don’t have too much D3 is suppressed and the D3 has no VDR receptors to latch on to. D3 therefore goes on to block the rest of the immune sytem because D3 needs a home, too.

    In conclusion, taking massive ammounts of D3 in this case could entirely possibly shut down your entire immune sytem!!

    Okay, then, so far so good. But what if you don’t have an autoimmune disease. How about this scenario. You take massive amount of D3 and you overwhelm the enzymes responsible for breaking down the excessive D3 in your system. The D3 willl now have no choice, but to infect the rest of your immune system causing a self induce autoimmune disease response. If gone on unchecked, then the path is similiarly bleak.

    Okay, so Nick, then why is it that when I started to take D, that I felt better? I’m glad that you asked that question my good person. D2 and the Pathogens block the VDR Reseptors and the massive ammounts of D3 that you are taking are blocking the rest of the immune sytem. This allows the pathogens to grow and colonize unchecked by the immune system. However, the immune system causes a die-off of the pathogens. When the pathogens die, they give off toxic substances that causes all kinds of symptoms from mild to cronic. If the immune system can no longer kill them, then your symptoms magically disappear.

    The kicker is that the pathogens continue on their merry way, year after year once the immune system is immobilized. A portion of the pathogens do die just like everything else and this becomes a self sustaining toxic die-off. Cronic Fatigue Syndrome is the result.

  194. NickD November 14th, 2009 at 2:24 pm 194

    Hi Amy and Paul,

    I wrote the following short essay on the Dr. Mercola facebook site.

    Okay, here is why, if you have an autoimmune disease, that you should avoid Steroidal D (D is not a Vitamin) otherwise known as D2 and D3. Pathogens produce binders that attach to VITAMIN D NUCLEAR RECEPTORS (VDR). D2 (25-D) does the same thing. Both of them block D3. This stops the D3 (1,25-D) from doing its job on the VDR. D3 now will seek other immune receptors like the T3 receptors and bind to them not allowing T3 to do its immune function. Taking massive amounts of D3 will only inhibit your ability to fight the pathogens and heal.

    Okay. So now, you are worried so you go to your doctor and test for D. He/she will probably do a D2 (25-D) test and tell you that it is low. They’ll tell you that nick is full of it and prescribe that you should increase your vitamin D intake!!! Just one minute, now. Before you leave the doctor’s office insist that you have them do a D3 (1,25-D) test. It will probably come back as off the charts high.

    Why is that, Nick? If you have an autoimmune disease, then the enzyme that is responsible for breaking down D3 (1,25-D), so that you don’t have too much D3, is suppressed. Also, the D3 has no VDR receptors to latch on to. D3 therefore goes on to block the rest of the immune system because D3 needs a home, too.

    In conclusion, taking massive amounts of D3 in this case could entirely possibly shut down your entire immune system!!

    Okay, then, so far so good, but what if you don’t have an autoimmune disease. How about this scenario, you take massive amount of D3 and you overwhelm the enzymes responsible for breaking down the excessive D3 in your system. The D3 will now have no choice, but to infect the rest of your immune system causing a self induced autoimmune disease response. If gone on unchecked, then the path is similarly bleak.

    Okay, so Nick, then why is it that when I started to take D, that I felt better? I’m glad that you asked that question my good person. D2 and the Pathogens block the VDR Receptors and the massive amounts of D3 that you are taking are blocking the rest of the immune system. This allows the pathogens to grow and colonize unchecked by the immune system. However, the immune system when working properly causes a die-off of the pathogens. When the pathogens die, they give off toxic substances that cause all kinds of symptoms from mild to chronic. If the immune system can no longer kill them, then your symptoms magically disappear.

    The kicker is that the pathogens continue on their merry way, year after year once the immune system is immobile. A portion of the pathogens do die just like everything else and this becomes a self sustaining toxic die-off. Chronic Fatigue Syndrome is the result.

  195. NickD November 14th, 2009 at 2:26 pm 195

    Sorry about the double post. I thought my first post didn’t register. It’s okay because the second one is a better edit.

  196. Ken Furber November 14th, 2009 at 4:34 pm 196

    Amy,

    I was just wondering if there is any way to edit something once it’s been posted on here. While reading over my last posting I’ve discovered some rather embarrassing grammatical and spelling errors. I even accidentally used the word “gambit” (a chess term) instead of “gamut” (full range) – what an idiot! Well maybe it doesn’t matter. Everyone probably knows how sick I’ve been so I guess a few mistakes are to be expected.

    Ken

  197. NickD November 14th, 2009 at 5:10 pm 197

    Hi Ken,

    You can edit your post right after you post. I believe that after someone posts after you, then it is impossible to rewrite your post. The other way is to copy your post and rewrite it and repost. I believe that Amy should be able to delete your old post for you.

    Nick D.

  198. NickD November 14th, 2009 at 5:39 pm 198

    As anyone heard of Gabriele Stahler?
    http://www.ustream.tv/recorded/2332513

  199. NickD November 14th, 2009 at 7:27 pm 199

    Gabriele Stahler says that they did a large study where everyone got a single dose of 100,000 IUs of D3 with no recordable problems. Their blood levels stayed high for a few months afterward.

  200. NickD November 14th, 2009 at 7:33 pm 200

    Amy,

    In a healthy person without this autoimmune disease causing VDR dysfunction, could a person tank up on enough steroid D3 to cause an autoimmune disease as I suspect? Is all of it stored in the fat cells and the liver or does some of it proliferate out and effect the rest of the immune system?

    Nick D.

  201. NickD November 15th, 2009 at 12:31 am 201

    Amy and Paul,
    I was digging away at ncbi and found this piece. I assume that you know about it already, but I thought I’d post it because I have not seen it yet on this site.
    Regards,
    Nick D.

    http://www.ncbi.nlm.nih.gov/pubmed/19758226?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=50

    Ann N Y Acad Sci. 2009 Sep;1173:757-65.

    Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease.
    Waterhouse JC, Perez TH, Albert PJ.

    Autoimmunity Research Foundation, Thousand Oaks, California 91360, USA. jcw@autoimmunityresearch.org

    Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency. Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. The VDR dysfunction causes a decline in innate immune function that causes susceptibility to additional infections that contribute to disease progression. Evidence has been accumulating that indicates that a number of autoimmune diseases can be reversed by gradually restoring VDR function with the VDR agonist olmesartan and subinhibitory dosages of certain bacteriostatic antibiotics. Diseases showing favorable responses to treatment so far include systemic lupus erythematosis, rheumatoid arthritis, scleroderma, sarcoidosis, Sjogren’s syndrome, autoimmune thyroid disease, psoriasis, ankylosing spondylitis, Reiter’s syndrome, type I and II diabetes mellitus, and uveitis. Disease reversal using this approach requires limitation of vitamin D in order to avoid contributing to dysfunction of nuclear receptors and subsequent negative consequences for immune and endocrine function. Immunopathological reactions accompanying bacterial cell death require a gradual elimination of pathogens over several years. Practical and theoretical implications are discussed, along with the compatibility of this model with current research.

    PMID: 19758226 [PubMed - indexed for MEDLINE]

  202. Amy Proal November 15th, 2009 at 12:34 am 202

    Dear Nick,

    This paper looks vaguely familiar. :)

    Thanks for your interest.

    Amy


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About Amy Proal

Amy and Zeus

Amy Proal graduated from Georgetown University in 2005 with a degree in biology. While at Georgetown, she wrote her senior thesis on Chronic Fatigue Syndrome and the Marshall Protocol.

Amy has spoken at several international conferences and authored several peer-reviewed papers on the intersection of bacteria and chronic disease.

If you have questions about the MP, please visit CureMyTh1.org where volunteer patient advocates will answer your questions. Another good resource is the MP Knowledge Base, which is scheduled to be completed within the next year.

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