This paper looks vaguely familiar.

Thanks for your interest.

Amy

http://www.ncbi.nlm.nih.gov/pubmed/19758226?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=50

Ann N Y Acad Sci. 2009 Sep;1173:757-65.

Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease.
Waterhouse JC, Perez TH, Albert PJ.

Autoimmunity Research Foundation, Thousand Oaks, California 91360, USA. jcw@autoimmunityresearch.org

Vitamin D research is discussed in light of the hypothesis that the lower average levels of vitamin D frequently observed in autoimmune disease are not a sign of deficiency. Instead, it is proposed that the lower levels result from chronic infection with intracellular bacteria that dysregulate vitamin D metabolism by causing vitamin D receptor (VDR) dysfunction within phagocytes. The VDR dysfunction causes a decline in innate immune function that causes susceptibility to additional infections that contribute to disease progression. Evidence has been accumulating that indicates that a number of autoimmune diseases can be reversed by gradually restoring VDR function with the VDR agonist olmesartan and subinhibitory dosages of certain bacteriostatic antibiotics. Diseases showing favorable responses to treatment so far include systemic lupus erythematosis, rheumatoid arthritis, scleroderma, sarcoidosis, Sjogren’s syndrome, autoimmune thyroid disease, psoriasis, ankylosing spondylitis, Reiter’s syndrome, type I and II diabetes mellitus, and uveitis. Disease reversal using this approach requires limitation of vitamin D in order to avoid contributing to dysfunction of nuclear receptors and subsequent negative consequences for immune and endocrine function. Immunopathological reactions accompanying bacterial cell death require a gradual elimination of pathogens over several years. Practical and theoretical implications are discussed, along with the compatibility of this model with current research.

PMID: 19758226 [PubMed - indexed for MEDLINE]

In a healthy person without this autoimmune disease causing VDR dysfunction, could a person tank up on enough steroid D3 to cause an autoimmune disease as I suspect? Is all of it stored in the fat cells and the liver or does some of it proliferate out and effect the rest of the immune system?

Nick D.

You can edit your post right after you post. I believe that after someone posts after you, then it is impossible to rewrite your post. The other way is to copy your post and rewrite it and repost. I believe that Amy should be able to delete your old post for you.

Nick D.

I was just wondering if there is any way to edit something once it’s been posted on here. While reading over my last posting I’ve discovered some rather embarrassing grammatical and spelling errors. I even accidentally used the word “gambit” (a chess term) instead of “gamut” (full range) – what an idiot! Well maybe it doesn’t matter. Everyone probably knows how sick I’ve been so I guess a few mistakes are to be expected.

Ken

I wrote the following short essay on the Dr. Mercola facebook site.

Okay, here is why, if you have an autoimmune disease, that you should avoid Steroidal D (D is not a Vitamin) otherwise known as D2 and D3. Pathogens produce binders that attach to VITAMIN D NUCLEAR RECEPTORS (VDR). D2 (25-D) does the same thing. Both of them block D3. This stops the D3 (1,25-D) from doing its job on the VDR. D3 now will seek other immune receptors like the T3 receptors and bind to them not allowing T3 to do its immune function. Taking massive amounts of D3 will only inhibit your ability to fight the pathogens and heal.

Okay. So now, you are worried so you go to your doctor and test for D. He/she will probably do a D2 (25-D) test and tell you that it is low. They’ll tell you that nick is full of it and prescribe that you should increase your vitamin D intake!!! Just one minute, now. Before you leave the doctor’s office insist that you have them do a D3 (1,25-D) test. It will probably come back as off the charts high.

Why is that, Nick? If you have an autoimmune disease, then the enzyme that is responsible for breaking down D3 (1,25-D), so that you don’t have too much D3, is suppressed. Also, the D3 has no VDR receptors to latch on to. D3 therefore goes on to block the rest of the immune system because D3 needs a home, too.

In conclusion, taking massive amounts of D3 in this case could entirely possibly shut down your entire immune system!!

Okay, then, so far so good, but what if you don’t have an autoimmune disease. How about this scenario, you take massive amount of D3 and you overwhelm the enzymes responsible for breaking down the excessive D3 in your system. The D3 will now have no choice, but to infect the rest of your immune system causing a self induced autoimmune disease response. If gone on unchecked, then the path is similarly bleak.

Okay, so Nick, then why is it that when I started to take D, that I felt better? I’m glad that you asked that question my good person. D2 and the Pathogens block the VDR Receptors and the massive amounts of D3 that you are taking are blocking the rest of the immune system. This allows the pathogens to grow and colonize unchecked by the immune system. However, the immune system when working properly causes a die-off of the pathogens. When the pathogens die, they give off toxic substances that cause all kinds of symptoms from mild to chronic. If the immune system can no longer kill them, then your symptoms magically disappear.

The kicker is that the pathogens continue on their merry way, year after year once the immune system is immobile. A portion of the pathogens do die just like everything else and this becomes a self sustaining toxic die-off. Chronic Fatigue Syndrome is the result.

regards,
Nick D

Okay, here is why, if you have an autoimmune disease, then you should avoid Steroidal D (D is not a Vitamin) otherwise known as D2 and D3. Pathogens produce binders that attach to VITAMIN D NUCLEAR RECEPTORS (VDR). D2 (25-D) does the same thing. Both of them block D3. This stops the D3 (1,25-D) from doing its job on the VDR. D3 now will seek other immune receptors like the T3 receptors and bind to them not allowing T3 to do its immune function. Taking massive amounts of D3 will only inhibit your ability to fight the pathogens and heal.

Okay. So now you’re worried. So you go to your doctor and test for D. He/she will probably do a D2 (25-D) test and tell you that it is low. They’ll tell you that nick is full of it and prescribe that you should increase your vitamin D intake!!! Just one minute, now. Before you leave the doctor’s office insist that you have them do a D3 (1,25-D) test. It will probably come back as off the charts high.

Why is that, Nick? If you have an autoimmune disease, then the enzyme that is resposible for breaking down D3 (1,25-D) so that you don’t have too much D3 is suppressed and the D3 has no VDR receptors to latch on to. D3 therefore goes on to block the rest of the immune sytem because D3 needs a home, too.

In conclusion, taking massive ammounts of D3 in this case could entirely possibly shut down your entire immune sytem!!

Okay, then, so far so good. But what if you don’t have an autoimmune disease. How about this scenario. You take massive amount of D3 and you overwhelm the enzymes responsible for breaking down the excessive D3 in your system. The D3 willl now have no choice, but to infect the rest of your immune system causing a self induce autoimmune disease response. If gone on unchecked, then the path is similiarly bleak.

Okay, so Nick, then why is it that when I started to take D, that I felt better? I’m glad that you asked that question my good person. D2 and the Pathogens block the VDR Reseptors and the massive ammounts of D3 that you are taking are blocking the rest of the immune sytem. This allows the pathogens to grow and colonize unchecked by the immune system. However, the immune system causes a die-off of the pathogens. When the pathogens die, they give off toxic substances that causes all kinds of symptoms from mild to cronic. If the immune system can no longer kill them, then your symptoms magically disappear.

The kicker is that the pathogens continue on their merry way, year after year once the immune system is immobilized. A portion of the pathogens do die just like everything else and this becomes a self sustaining toxic die-off. Cronic Fatigue Syndrome is the result.